Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794488515> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2794488515 abstract "Objective: Fungal infection on the skin is one of the common dermatological diseases especially for the people living in hot and humid climatic conditions. Conventional topical formulations suffer from its own limitations such as lack of site-specific delivery, drug bioavailability, and patient compliance. Curcumin oil was selected as bioactive molecules which target fungal infection which also act as an oil phase for microemulsion preparation. Another strategy was implemented in this research study was to protect the skin from excessive exposure from free radicals by supporting the skin endogenous antioxidant system by adding ascorbic acid (Vitamin C) as an adjunct. Materials and Methods: Micro emulsion gel was formulated with curcumin oil as an active ingredient as well as an oil phase along with ascorbic acid as an adjunct (antioxidant), tween 20, and isopropanol as surfactant and cosurfactant, respectively. Carbopol 940 was chosen as a polymer for the preparation of gel. Pseudoternary phase diagram of microemulsion with various surfactant/cosurfactant ratios (1:1–4:1) were constructed to study the phase behavior. Minimum inhibitory concentration study and Fourier transform infrared (FTIR) study was conducted to check antifungal activity and possible drug-excipient interactions, respectively. The developed formulations were characterized for physicochemical parameters such as globule size, zeta potential, viscosity, pH, etc. The optimized microemulsion formulations were further loaded into the carbopol gel base and evaluated. Results: Surfactant/cosurfactant weight ratio 3:1 was found to be largest in the percentage area of micro emulsion region. FTIR study did not show any potential drug-excipient interaction and curcumin oil showed considerably greater antifungal activity as compared to clotrimazole. The physical appearances of all the formulations were found to be yellowish, transparent, clear, glossy, and consistent. The pH, viscosity, droplet size of all the formulations was found to be in the acceptable range. From the results of in vitro drug release, approximately 90% of drug released was noted at the end of 10 h and ex vivo release study showed possible permeation mechanism of drug. In vitro antioxidant activity showed that microemulsion gel containing ascorbic acid possess significant free radical scavenging activity in a concentration-dependent manner. In vivo study showed that microemulsion gel containing curcumin oil and ascorbic acid has significant antifungal and antioxidant effect. Conclusions: Curcumin oil was successfully incorporated into topical microemulsion gel prepared with Vitamin C used as an adjunct and showed good spreadability, viscosity, drug release, in vitro antioxidant activity, and in vivo antifungal activity." @default.
- W2794488515 created "2018-04-06" @default.
- W2794488515 creator A5072760178 @default.
- W2794488515 date "2019-08-30" @default.
- W2794488515 modified "2023-09-26" @default.
- W2794488515 title "Antifungal and Antioxidant therapy: For the treatment of fungal infection with microemulsion gel containing curcumin and vitamin C" @default.
- W2794488515 hasPublicationYear "2019" @default.
- W2794488515 type Work @default.
- W2794488515 sameAs 2794488515 @default.
- W2794488515 citedByCount "0" @default.
- W2794488515 crossrefType "book" @default.
- W2794488515 hasAuthorship W2794488515A5072760178 @default.
- W2794488515 hasConcept C178790620 @default.
- W2794488515 hasConcept C181389837 @default.
- W2794488515 hasConcept C185592680 @default.
- W2794488515 hasConcept C190119865 @default.
- W2794488515 hasConcept C2777239854 @default.
- W2794488515 hasConcept C2777897440 @default.
- W2794488515 hasConcept C2778004101 @default.
- W2794488515 hasConcept C2778123984 @default.
- W2794488515 hasConcept C2778250585 @default.
- W2794488515 hasConcept C2780022331 @default.
- W2794488515 hasConcept C2986274086 @default.
- W2794488515 hasConcept C31903555 @default.
- W2794488515 hasConcept C43617362 @default.
- W2794488515 hasConcept C45904493 @default.
- W2794488515 hasConcept C55493867 @default.
- W2794488515 hasConcept C58226133 @default.
- W2794488515 hasConcept C71924100 @default.
- W2794488515 hasConcept C98274493 @default.
- W2794488515 hasConceptScore W2794488515C178790620 @default.
- W2794488515 hasConceptScore W2794488515C181389837 @default.
- W2794488515 hasConceptScore W2794488515C185592680 @default.
- W2794488515 hasConceptScore W2794488515C190119865 @default.
- W2794488515 hasConceptScore W2794488515C2777239854 @default.
- W2794488515 hasConceptScore W2794488515C2777897440 @default.
- W2794488515 hasConceptScore W2794488515C2778004101 @default.
- W2794488515 hasConceptScore W2794488515C2778123984 @default.
- W2794488515 hasConceptScore W2794488515C2778250585 @default.
- W2794488515 hasConceptScore W2794488515C2780022331 @default.
- W2794488515 hasConceptScore W2794488515C2986274086 @default.
- W2794488515 hasConceptScore W2794488515C31903555 @default.
- W2794488515 hasConceptScore W2794488515C43617362 @default.
- W2794488515 hasConceptScore W2794488515C45904493 @default.
- W2794488515 hasConceptScore W2794488515C55493867 @default.
- W2794488515 hasConceptScore W2794488515C58226133 @default.
- W2794488515 hasConceptScore W2794488515C71924100 @default.
- W2794488515 hasConceptScore W2794488515C98274493 @default.
- W2794488515 hasLocation W27944885151 @default.
- W2794488515 hasOpenAccess W2794488515 @default.
- W2794488515 hasPrimaryLocation W27944885151 @default.
- W2794488515 hasRelatedWork W1972328324 @default.
- W2794488515 hasRelatedWork W2076185097 @default.
- W2794488515 hasRelatedWork W2079269112 @default.
- W2794488515 hasRelatedWork W2103550117 @default.
- W2794488515 hasRelatedWork W2120164609 @default.
- W2794488515 hasRelatedWork W2123158310 @default.
- W2794488515 hasRelatedWork W2184200030 @default.
- W2794488515 hasRelatedWork W2757784936 @default.
- W2794488515 hasRelatedWork W2771510768 @default.
- W2794488515 hasRelatedWork W2787725006 @default.
- W2794488515 hasRelatedWork W2849169772 @default.
- W2794488515 hasRelatedWork W2897131400 @default.
- W2794488515 hasRelatedWork W2910337726 @default.
- W2794488515 hasRelatedWork W3008388579 @default.
- W2794488515 hasRelatedWork W3036013186 @default.
- W2794488515 hasRelatedWork W3090232584 @default.
- W2794488515 hasRelatedWork W3158754242 @default.
- W2794488515 hasRelatedWork W368844142 @default.
- W2794488515 hasRelatedWork W2181986749 @default.
- W2794488515 hasRelatedWork W3167613722 @default.
- W2794488515 isParatext "false" @default.
- W2794488515 isRetracted "false" @default.
- W2794488515 magId "2794488515" @default.
- W2794488515 workType "book" @default.