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- W2794497018 abstract "BackgroundBased on decellularisation and cleaning processes of trabecular bone and fibrocartilage, an osteochondral allograft has been developed.MaterialThe chemical process, established thanks to bone and fibrocartilage data, included an efficient viroinactivation step. The raw material was a tibial plateau collected during knee arthroplasty, cut in cylinders strictly selected (>2mm cartilage height and total height between 10 and 16mm). The grafts were freeze-dried and gamma sterilised.MethodsDecellularisation and structure integrity were validated based on histological analysis, before and after treatment. Mesenchymal Stem Cells (MSC) proliferation in contact with the graft was evaluated to validate the biocompatibility. Biomechanics of the cartilage was studied to determine the compressive resistance before and after treatment. Proof of concept has been completed on femoral condyles in a rabbit model: osteochondral allografts of rabbit were prepared from femoral condyles, processed like human allograf..." @default.
- W2794497018 created "2018-04-06" @default.
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- W2794497018 date "2018-02-21" @default.
- W2794497018 modified "2023-09-26" @default.
- W2794497018 title "DECELLULARISED OSTEOCHONDRAL GRAFT: PROCESS DEVELOPMENT" @default.
- W2794497018 hasPublicationYear "2018" @default.
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