FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W279462010> ?p ?o ?g. }

• W279462010 endingPage "38" @default.
• W279462010 startingPage "30" @default.
• W279462010 abstract "Surface modified microneedle (MN) arrays are being developed to capture circulating biomarkers from the skin, but inefficiency and unreliability of the current method limit its clinical applications. We describe here that illumination of a tiny area of the skin with hemoglobin-preferably absorbent laser increased the amount of circulating biomarkers in the upper dermis by more than 1000-fold. The hemoglobin-specific light altered the permeability of capillaries leading to extravasation of molecules but not blood cells beneath the skin involved. When specific probe-coated MN arrays were applied into the laser-treated skin, the biomarkers accumulated in the upper dermis were reliably, accurately, and sufficiently captured as early as 15 min of the assay. The maximal binding occurred in 1 h in a manner independent of penetration depth or a molecular mass of the biomarker. With anti-fluorescein isothiocyanate (FITC)-MNs, we were able to measure blood concentrations of FITC in mice receiving FITC intravenously. The sensitivity and accuracy were comparable to those attained by fluorescence spectrophotometer. Likewise, MNs containing influenza hemagglutinin (HA) could detect anti-HA antibody in mice or swine receiving influenza vaccines as effectively as standard immunoassays. The novel, minimally invasive approach holds great promise for measurement of multiple biomarkers by a single array for point-of-care diagnosis." @default.
• W279462010 created "2016-06-24" @default.
• W279462010 creator A5023703260 @default.
• W279462010 creator A5027958721 @default.
• W279462010 creator A5043091074 @default.
• W279462010 creator A5050874455 @default.
• W279462010 creator A5087218324 @default.
• W279462010 date "2015-08-01" @default.
• W279462010 modified "2023-10-16" @default.
• W279462010 title "Sample-free quantification of blood biomarkers via laser-treated skin" @default.
• W279462010 cites W1782810126 @default.
• W279462010 cites W1966694235 @default.
• W279462010 cites W1967642964 @default.
• W279462010 cites W1972456121 @default.
• W279462010 cites W1974890646 @default.
• W279462010 cites W1976704354 @default.
• W279462010 cites W1989437429 @default.
• W279462010 cites W2001883045 @default.
• W279462010 cites W2003570790 @default.
• W279462010 cites W2016228252 @default.
• W279462010 cites W2022779476 @default.
• W279462010 cites W2032569684 @default.
• W279462010 cites W2039779814 @default.
• W279462010 cites W2043803772 @default.
• W279462010 cites W2044187349 @default.
• W279462010 cites W2047844869 @default.
• W279462010 cites W2055815649 @default.
• W279462010 cites W2055885674 @default.
• W279462010 cites W2059458766 @default.
• W279462010 cites W2073660854 @default.
• W279462010 cites W2081316578 @default.
• W279462010 cites W2082877002 @default.
• W279462010 cites W2110828355 @default.
• W279462010 cites W2119302422 @default.
• W279462010 cites W2124074677 @default.
• W279462010 cites W2148296626 @default.
• W279462010 cites W2160061958 @default.
• W279462010 cites W2344489494 @default.
• W279462010 doi "https://doi.org/10.1016/j.biomaterials.2015.04.040" @default.
• W279462010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4467690" @default.
• W279462010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25950985" @default.
• W279462010 hasPublicationYear "2015" @default.
• W279462010 type Work @default.
• W279462010 sameAs 279462010 @default.
• W279462010 citedByCount "16" @default.
• W279462010 countsByYear W2794620102016 @default.
• W279462010 countsByYear W2794620102017 @default.
• W279462010 countsByYear W2794620102018 @default.
• W279462010 countsByYear W2794620102019 @default.
• W279462010 countsByYear W2794620102020 @default.
• W279462010 countsByYear W2794620102021 @default.
• W279462010 countsByYear W2794620102022 @default.
• W279462010 countsByYear W2794620102023 @default.
• W279462010 crossrefType "journal-article" @default.
• W279462010 hasAuthorship W279462010A5023703260 @default.
• W279462010 hasAuthorship W279462010A5027958721 @default.
• W279462010 hasAuthorship W279462010A5043091074 @default.
• W279462010 hasAuthorship W279462010A5050874455 @default.
• W279462010 hasAuthorship W279462010A5087218324 @default.
• W279462010 hasBestOaLocation W2794620102 @default.
• W279462010 hasConcept C10390740 @default.
• W279462010 hasConcept C120665830 @default.
• W279462010 hasConcept C121332964 @default.
• W279462010 hasConcept C126322002 @default.
• W279462010 hasConcept C136229726 @default.
• W279462010 hasConcept C142724271 @default.
• W279462010 hasConcept C185592680 @default.
• W279462010 hasConcept C192562407 @default.
• W279462010 hasConcept C2777019933 @default.
• W279462010 hasConcept C2777459323 @default.
• W279462010 hasConcept C2777624698 @default.
• W279462010 hasConcept C2778917026 @default.
• W279462010 hasConcept C2779540182 @default.
• W279462010 hasConcept C2781197716 @default.
• W279462010 hasConcept C43617362 @default.
• W279462010 hasConcept C54355233 @default.
• W279462010 hasConcept C55493867 @default.
• W279462010 hasConcept C71924100 @default.
• W279462010 hasConcept C86803240 @default.
• W279462010 hasConcept C91881484 @default.
• W279462010 hasConceptScore W279462010C10390740 @default.
• W279462010 hasConceptScore W279462010C120665830 @default.
• W279462010 hasConceptScore W279462010C121332964 @default.
• W279462010 hasConceptScore W279462010C126322002 @default.
• W279462010 hasConceptScore W279462010C136229726 @default.
• W279462010 hasConceptScore W279462010C142724271 @default.
• W279462010 hasConceptScore W279462010C185592680 @default.
• W279462010 hasConceptScore W279462010C192562407 @default.
• W279462010 hasConceptScore W279462010C2777019933 @default.
• W279462010 hasConceptScore W279462010C2777459323 @default.
• W279462010 hasConceptScore W279462010C2777624698 @default.
• W279462010 hasConceptScore W279462010C2778917026 @default.
• W279462010 hasConceptScore W279462010C2779540182 @default.
• W279462010 hasConceptScore W279462010C2781197716 @default.
• W279462010 hasConceptScore W279462010C43617362 @default.
• W279462010 hasConceptScore W279462010C54355233 @default.
• W279462010 hasConceptScore W279462010C55493867 @default.
• W279462010 hasConceptScore W279462010C71924100 @default.

• next