Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794671187> ?p ?o ?g. }
- W2794671187 endingPage "150" @default.
- W2794671187 startingPage "139" @default.
- W2794671187 abstract "Cryptococcal meningitis remains a significant cause of morbidity and mortality amongst patients living with human immunodeficiency virus (HIV). The prevalence in the developed world has decreased as HIV is being diagnosed earlier, but is still significant, and the prevalence in resource-limited settings is exceedingly high. The presenting symptoms usually include a headache, fever, and, less often, cranial nerve abnormalities. Space-occupying lesions do occur, but are rare. Once diagnosed, patients should be treated with a combination of amphotericin and flucytosine, with step-down therapy to fluconazole for a minimum of a year, or until the CD4 count is above 100 cells/μL, whichever is longer. In the acute phase of treatment increased opening pressure is common, which should be managed aggressively with frequent lumbar punctures, or through neurosurgical interventions (lumbar drains, ventriculoperitoneal shunts) if those fail. Antiretrovirals should be delayed at least 2 weeks, but maybe as many as 10 weeks, after initiation of antifungal therapy in order to prevent clinical or subclinical immune reconstitution inflammatory syndrome (IRIS), which may lead to increased mortality. However, if IRIS does develop, there is no role for antiretroviral interruption, and the condition should be managed supportively by use of anti-inflammatories and aggressive management of elevated opening pressure, if present. Steroids should be administered for specific indications only (IRIS or cryptococcoma with cerebral edema and risk of herniation) as routine use of steroids increases mortality in cryptococcal meningitis." @default.
- W2794671187 created "2018-04-06" @default.
- W2794671187 creator A5028882117 @default.
- W2794671187 creator A5058226785 @default.
- W2794671187 date "2018-01-01" @default.
- W2794671187 modified "2023-10-18" @default.
- W2794671187 title "Cryptococcal meningitis in AIDS" @default.
- W2794671187 cites W1653184426 @default.
- W2794671187 cites W1722495726 @default.
- W2794671187 cites W1929400276 @default.
- W2794671187 cites W1963966543 @default.
- W2794671187 cites W1970753500 @default.
- W2794671187 cites W1977154798 @default.
- W2794671187 cites W1979894181 @default.
- W2794671187 cites W1980508929 @default.
- W2794671187 cites W1982177139 @default.
- W2794671187 cites W1985214490 @default.
- W2794671187 cites W1987196722 @default.
- W2794671187 cites W1988049097 @default.
- W2794671187 cites W1994415754 @default.
- W2794671187 cites W1997032499 @default.
- W2794671187 cites W1997967640 @default.
- W2794671187 cites W2008628351 @default.
- W2794671187 cites W2010517007 @default.
- W2794671187 cites W2022188569 @default.
- W2794671187 cites W2028893274 @default.
- W2794671187 cites W2030000278 @default.
- W2794671187 cites W2030925037 @default.
- W2794671187 cites W2035341197 @default.
- W2794671187 cites W2039418725 @default.
- W2794671187 cites W2039650402 @default.
- W2794671187 cites W2042387179 @default.
- W2794671187 cites W2050450161 @default.
- W2794671187 cites W2051185073 @default.
- W2794671187 cites W2053427809 @default.
- W2794671187 cites W2055905833 @default.
- W2794671187 cites W2061287699 @default.
- W2794671187 cites W2063611602 @default.
- W2794671187 cites W2068790641 @default.
- W2794671187 cites W2072662158 @default.
- W2794671187 cites W2072853512 @default.
- W2794671187 cites W2073363331 @default.
- W2794671187 cites W2079152396 @default.
- W2794671187 cites W2079513681 @default.
- W2794671187 cites W2084004341 @default.
- W2794671187 cites W2085986706 @default.
- W2794671187 cites W2087637312 @default.
- W2794671187 cites W2095030236 @default.
- W2794671187 cites W2096006098 @default.
- W2794671187 cites W2096140932 @default.
- W2794671187 cites W2096476576 @default.
- W2794671187 cites W2097554202 @default.
- W2794671187 cites W2098730474 @default.
- W2794671187 cites W2100645908 @default.
- W2794671187 cites W2100651734 @default.
- W2794671187 cites W2100980414 @default.
- W2794671187 cites W2101195119 @default.
- W2794671187 cites W2104264048 @default.
- W2794671187 cites W2105946152 @default.
- W2794671187 cites W2107409415 @default.
- W2794671187 cites W2108521877 @default.
- W2794671187 cites W2109687620 @default.
- W2794671187 cites W2110075660 @default.
- W2794671187 cites W2110934408 @default.
- W2794671187 cites W2112956661 @default.
- W2794671187 cites W2113417401 @default.
- W2794671187 cites W2113817312 @default.
- W2794671187 cites W2117574372 @default.
- W2794671187 cites W2119878310 @default.
- W2794671187 cites W2120277859 @default.
- W2794671187 cites W2120977684 @default.
- W2794671187 cites W2121822883 @default.
- W2794671187 cites W2124247496 @default.
- W2794671187 cites W2125247264 @default.
- W2794671187 cites W2125695159 @default.
- W2794671187 cites W2127250507 @default.
- W2794671187 cites W2128165683 @default.
- W2794671187 cites W2128305340 @default.
- W2794671187 cites W2130316654 @default.
- W2794671187 cites W2131416019 @default.
- W2794671187 cites W2132006825 @default.
- W2794671187 cites W2132310675 @default.
- W2794671187 cites W2135107688 @default.
- W2794671187 cites W2136955446 @default.
- W2794671187 cites W2139368207 @default.
- W2794671187 cites W2139861350 @default.
- W2794671187 cites W2141305342 @default.
- W2794671187 cites W2143732246 @default.
- W2794671187 cites W2143769286 @default.
- W2794671187 cites W2143928313 @default.
- W2794671187 cites W2144543496 @default.
- W2794671187 cites W2147720061 @default.
- W2794671187 cites W2148002357 @default.
- W2794671187 cites W2148956152 @default.
- W2794671187 cites W2149684675 @default.
- W2794671187 cites W2150376850 @default.
- W2794671187 cites W2151308259 @default.
- W2794671187 cites W2152453336 @default.