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- W2794691708 abstract "Finding a role for PNECs in asthma Pulmonary neuroendocrine cells (PNECs) are a rare cell type located in airway and alveolar epithelia and are often in contact with sensory nerve fibers. They have a wide phylogenic distribution and are found even in the relatively primitive lungs of amphibia and reptiles, suggesting a critical function. Sui et al. found that mice lacking PNECs have suppressed type 2 (allergic) immune responses. PNECs were observed in close proximity to group 2 innate lymphoid cells (ILC2s) around airway branch points. The PNECs enhanced ILC2 activity by secreting CGRP (calcitonin gene-related peptide). They also induced goblet-cell hyperplasia via the neurotransmitter GABA (γ-aminobutyric acid). Interestingly, human asthma patients were found to have increased PNEC numbers, suggesting a potential therapeutic target for the treatment of asthma. Science , this issue p. eaan8546" @default.
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- W2794691708 date "2018-06-08" @default.
- W2794691708 modified "2023-10-11" @default.
- W2794691708 title "Pulmonary neuroendocrine cells amplify allergic asthma responses" @default.
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- W2794691708 doi "https://doi.org/10.1126/science.aan8546" @default.
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