Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794691806> ?p ?o ?g. }
- W2794691806 endingPage "520" @default.
- W2794691806 startingPage "507" @default.
- W2794691806 abstract "The infectivity of HIV depends on overcoming APOBEC3 (A3) innate immunity, predominantly through the expression of the viral protein Vif, which induces A3 degradation in the proteasome. Disruption of the functional interactions of Vif enables A3 mutagenesis of the HIV genome during viral replication, which can result in a broadly neutralizing antiviral effect. Vif function requires self-association along with interactions with A3 proteins, protein chaperones, and factors of the ubiquitination machinery and these are described here as a potential platform for novel antiviral drug discovery. This Review will examine the current state of development of Vif inhibitors that we believe to have therapeutic and functional cure potential." @default.
- W2794691806 created "2018-04-06" @default.
- W2794691806 creator A5008364094 @default.
- W2794691806 creator A5050433390 @default.
- W2794691806 creator A5060979368 @default.
- W2794691806 date "2018-05-01" @default.
- W2794691806 modified "2023-09-24" @default.
- W2794691806 title "A New Class of Antiretroviral Enabling Innate Immunity by Protecting APOBEC3 from HIV Vif-Dependent Degradation" @default.
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