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- W2794708474 abstract "BackgroundAseptic loosening of prostheses is the most common cause for failure in total joint arthroplasty. Particulate wear debris induces a non-stop inflammatory-like response resulting in the formation of a layer of fibrous periprosthetic tissue at the bone/implant interface. The current treatment is an invasive revision joint replacement surgery. However, this procedure has a high morbidity rate, therefore, a less invasive alternative is necessary. One approach could be to re-establish osseointegration of the joint prosthesis by inducing osteoblast differentiation in the periprosthetic tissue. Therefore, the aim of this study was to investigate the capacity of periprosthetic tissue cells to differentiate into the osteoblast lineage.MethodsPeriprosthetic tissue samples were collected during revision surgery of aseptic loosened hip prostheses, after which cells were isolated by collagenase digestion. Of 14 different donors, cells from passage 1 till 3 were used for differentiation experiments. During 21..." @default.
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- W2794708474 date "2018-02-21" @default.
- W2794708474 modified "2023-09-24" @default.
- W2794708474 title "REFIXATION OF LOOSENED HIP PROSTHESES: OSTEOGENIC CAPACITY OF PERIPROSTHETIC TISSUE CELLS" @default.
- W2794708474 hasPublicationYear "2018" @default.
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