Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794740557> ?p ?o ?g. }
- W2794740557 abstract "Dynein is a cytoskeletal molecular motor protein that transports cellular cargoes along microtubules. Biomimetic synthetic peptides designed to bind dynein have been shown to acquire dynamic properties such as cell accumulation and active intra- and inter-cellular motion through cell-to-cell contacts and projections to distant cells. On the basis of these properties dynein-binding peptides could be used to functionalize nanoparticles for drug delivery applications.Here, we show that gold nanoparticles modified with dynein-binding delivery sequences become mobile, powered by molecular motor proteins. Modified nanoparticles showed dynamic properties, such as travelling the cytosol, crossing intracellular barriers and shuttling the nuclear membrane. Furthermore, nanoparticles were transported from one cell to another through cell-to-cell contacts and quickly spread to distant cells through cell projections.The capacity of these motor-bound nanoparticles to spread to many cells and increasing cellular retention, thus avoiding losses and allowing lower dosage, could make them candidate carriers for drug delivery." @default.
- W2794740557 created "2018-04-06" @default.
- W2794740557 creator A5000199411 @default.
- W2794740557 creator A5002244928 @default.
- W2794740557 creator A5006395432 @default.
- W2794740557 creator A5025706208 @default.
- W2794740557 creator A5026998248 @default.
- W2794740557 creator A5038482358 @default.
- W2794740557 creator A5056746541 @default.
- W2794740557 creator A5067928937 @default.
- W2794740557 date "2018-03-30" @default.
- W2794740557 modified "2023-10-16" @default.
- W2794740557 title "Nanoparticles engineered to bind cellular motors for efficient delivery" @default.
- W2794740557 cites W1588942504 @default.
- W2794740557 cites W1963851313 @default.
- W2794740557 cites W1964074623 @default.
- W2794740557 cites W1965600613 @default.
- W2794740557 cites W1973127857 @default.
- W2794740557 cites W1989065176 @default.
- W2794740557 cites W1998020561 @default.
- W2794740557 cites W2001860659 @default.
- W2794740557 cites W2015513114 @default.
- W2794740557 cites W2016467723 @default.
- W2794740557 cites W2019112006 @default.
- W2794740557 cites W2022616146 @default.
- W2794740557 cites W2024922005 @default.
- W2794740557 cites W2027137358 @default.
- W2794740557 cites W2033096857 @default.
- W2794740557 cites W2042487912 @default.
- W2794740557 cites W2051695714 @default.
- W2794740557 cites W2061126550 @default.
- W2794740557 cites W2061445529 @default.
- W2794740557 cites W2063065954 @default.
- W2794740557 cites W2068761333 @default.
- W2794740557 cites W2069690968 @default.
- W2794740557 cites W2069934117 @default.
- W2794740557 cites W2083139077 @default.
- W2794740557 cites W2084569287 @default.
- W2794740557 cites W2097269403 @default.
- W2794740557 cites W2103617829 @default.
- W2794740557 cites W2108187125 @default.
- W2794740557 cites W2108844676 @default.
- W2794740557 cites W2115552839 @default.
- W2794740557 cites W2115850825 @default.
- W2794740557 cites W2121838412 @default.
- W2794740557 cites W2136303496 @default.
- W2794740557 cites W2137115293 @default.
- W2794740557 cites W2139163640 @default.
- W2794740557 cites W2140294035 @default.
- W2794740557 cites W2144620508 @default.
- W2794740557 cites W2147122297 @default.
- W2794740557 cites W2156187175 @default.
- W2794740557 cites W2158799849 @default.
- W2794740557 cites W2163326536 @default.
- W2794740557 cites W2163970736 @default.
- W2794740557 cites W2171667802 @default.
- W2794740557 cites W2328639389 @default.
- W2794740557 cites W2335068266 @default.
- W2794740557 cites W2402319960 @default.
- W2794740557 cites W2567373641 @default.
- W2794740557 cites W4246573955 @default.
- W2794740557 doi "https://doi.org/10.1186/s12951-018-0354-1" @default.
- W2794740557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5877387" @default.
- W2794740557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29602307" @default.
- W2794740557 hasPublicationYear "2018" @default.
- W2794740557 type Work @default.
- W2794740557 sameAs 2794740557 @default.
- W2794740557 citedByCount "14" @default.
- W2794740557 countsByYear W27947405572018 @default.
- W2794740557 countsByYear W27947405572019 @default.
- W2794740557 countsByYear W27947405572020 @default.
- W2794740557 countsByYear W27947405572021 @default.
- W2794740557 countsByYear W27947405572022 @default.
- W2794740557 countsByYear W27947405572023 @default.
- W2794740557 crossrefType "journal-article" @default.
- W2794740557 hasAuthorship W2794740557A5000199411 @default.
- W2794740557 hasAuthorship W2794740557A5002244928 @default.
- W2794740557 hasAuthorship W2794740557A5006395432 @default.
- W2794740557 hasAuthorship W2794740557A5025706208 @default.
- W2794740557 hasAuthorship W2794740557A5026998248 @default.
- W2794740557 hasAuthorship W2794740557A5038482358 @default.
- W2794740557 hasAuthorship W2794740557A5056746541 @default.
- W2794740557 hasAuthorship W2794740557A5067928937 @default.
- W2794740557 hasBestOaLocation W27947405571 @default.
- W2794740557 hasConcept C106987784 @default.
- W2794740557 hasConcept C12554922 @default.
- W2794740557 hasConcept C139770010 @default.
- W2794740557 hasConcept C142669718 @default.
- W2794740557 hasConcept C1491633281 @default.
- W2794740557 hasConcept C160408235 @default.
- W2794740557 hasConcept C171250308 @default.
- W2794740557 hasConcept C181199279 @default.
- W2794740557 hasConcept C185592680 @default.
- W2794740557 hasConcept C192562407 @default.
- W2794740557 hasConcept C20418707 @default.
- W2794740557 hasConcept C2778106830 @default.
- W2794740557 hasConcept C2779820397 @default.
- W2794740557 hasConcept C55493867 @default.
- W2794740557 hasConcept C79879829 @default.
- W2794740557 hasConcept C86803240 @default.