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- W2794778348 endingPage "3307" @default.
- W2794778348 startingPage "3298" @default.
- W2794778348 abstract "Abstract Septins are a conserved family of cytoskeletal GTP ases present in different organisms, including yeast, drosophila, Caenorhabditis elegans and humans. In humans, septins are involved in various cellular processes, including exocytosis, apoptosis, leukemogenesis, carcinogenesis and neurodegeneration. Septin 7 is unique out of 13 human septins. Mammalian septin 6, septin 7, septin 2 and septin 9 coisolate together in complexes to form the core unit for the generation of the septin filaments. Physiological septin filaments are hetero‐oligomeric complexes consisting of core septin hexamers and octamers. Furthermore, septin 7 plays a crucial role in cytokinesis and mitosis. Septin 7 is localized to the filopodia and branches of developing hippocampal neurons, and is the most abundant septin in the adult rat forebrain as well as a structural component of the human and mouse sperm annuli. Septin 7 is crucial to the spine morphogenesis and dendrite growth in neurons, and is also a structural constituent of the annulus in human and mouse sperm. It can suppress growth of some tumours such as glioma and papillary thyroid carcinoma. However, the molecular mechanisms of involvement of septin 7 in human disease, especially in the development of cancer, remain unclear. This review focuses on the structure, function and mechanism of septin 7 in vivo, and summarizes the role of septin 7 in cell proliferation, cytokinesis, nervous and reproductive systems, as well as the underlying molecular events linking septin 7 to various diseases, such as Alzheimer's disease, schizophrenia, neuropsychiatric systemic lupus erythematosus, tumour and so on." @default.
- W2794778348 created "2018-04-06" @default.
- W2794778348 creator A5003075563 @default.
- W2794778348 creator A5009327702 @default.
- W2794778348 creator A5014455930 @default.
- W2794778348 creator A5053107773 @default.
- W2794778348 creator A5083574483 @default.
- W2794778348 creator A5085532750 @default.
- W2794778348 date "2018-03-30" @default.
- W2794778348 modified "2023-10-12" @default.
- W2794778348 title "The role of septin 7 in physiology and pathological disease: A systematic review of current status" @default.
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