FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794792009> ?p ?o ?g. }

• W2794792009 endingPage "456" @default.
• W2794792009 startingPage "448" @default.
• W2794792009 abstract "No AccessJournal of UrologyNew Technology and Techniques1 Aug 2018Anterior Urethroplasty Using a New Tissue Engineered Oral Mucosa Graft: Surgical Techniques and Outcomes Guido Barbagli, Ilgar Akbarov, Axel Heidenreich, Vahudin Zugor, Roberto Olianas, Maurizio Aragona, Giuseppe Romano, Ulf Balsmeyer, Dirk Fahlenkamp, Udo Rebmann, Diana Standhaft, and Massimo Lazzeri Guido BarbagliGuido Barbagli Centro Chirurgico Toscano, Arezzo, Italy Equal study contribution. Financial interest and/or other relationship with UroTiss Europe. More articles by this author , Ilgar AkbarovIlgar Akbarov Clinic and Policlinic for Urology, University of Cologne, Cologne, Germany Equal study contribution. More articles by this author , Axel HeidenreichAxel Heidenreich Clinic and Policlinic for Urology, University of Cologne, Cologne, Germany More articles by this author , Vahudin ZugorVahudin Zugor Clinic and Policlinic for Urology, University of Cologne, Cologne, Germany More articles by this author , Roberto OlianasRoberto Olianas Department of Urology, Klinikum Lueneburg, Lueneburg, Germany More articles by this author , Maurizio AragonaMaurizio Aragona Department of Urology, Klinikum Lueneburg, Lueneburg, Germany More articles by this author , Giuseppe RomanoGiuseppe Romano Urology Unit, Ospedale Santa Maria alla Gruccia, Montevarchi, Italy More articles by this author , Ulf BalsmeyerUlf Balsmeyer Department of Urology, Zeisigwald Clinics Bethanien, Chemnitz, Germany More articles by this author , Dirk FahlenkampDirk Fahlenkamp Department of Urology, Zeisigwald Clinics Bethanien, Chemnitz, Germany More articles by this author , Udo RebmannUdo Rebmann Department of Urology, Diakonissen Hospital Dessau, Dessau, Germany More articles by this author , Diana StandhaftDiana Standhaft Department of Urology, Diakonissen Hospital Dessau, Dessau, Germany More articles by this author , and Massimo LazzeriMassimo Lazzeri Istituto Clinico Humanitas IRCCS, Clinical and Research Hospital, Rozzano, Italy More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.3102AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We investigated whether tissue engineered material may be adopted using standard techniques for anterior urethroplasty. Materials and Methods: We performed a retrospective multicenter study in patients with recurrent strictures, excluding those with failed hypospadias, lichen sclerosus, traumatic and posterior strictures. A 0.5 cm2 oral mucosa biopsy was taken from the patient cheek and sent to the laboratory to manufacture the graft. After 3 weeks the tissue engineered oral mucosal MukoCell® graft was sent to the hospital for urethroplasty. Four techniques were used, including ventral onlay, dorsal onlay, dorsal inlay and a combined technique. Cystourethrography was performed 1 month postoperatively. Patients underwent clinical evaluation, uroflowmetry and post-void residual urine measurement every 6 months. When the patient showed obstructive symptoms, defined as maximum urine flow less than 12 ml per second, the urethrography was repeated. Patients who underwent further treatment for recurrent stricture were classified as having treatment failure. Results: Of the 38 patients with a median age of 57 years who were included in study the strictures were penile in 3 (7.9%), bulbar in 29 (76.3%) and penobulbar in 6 (15.8%). Median stricture length was 5 cm and median followup was 55 months. Treatment succeeded in 32 of the 38 patients (84.2%) and failed in 15.8%. Success was achieved in 85.7% of ventral onlay, 83.3% of dorsal onlay, 80% of dorsal inlay and 100% of combined technique cases. No local or systemic adverse reactions due to the engineered material were noted. Conclusions: Our findings show that a tissue engineered oral mucosa graft can be implanted using the same techniques suggested for anterior urethroplasty and native oral mucosa, and guaranteeing a similar success rate. References 1 : Lancet Commission: stem cells and regenerative medicine. Lancet2017; 390: 1623. Google Scholar 2 : Clinical experience with urethral reconstruction using tissue-engineered oral mucosa: a quiet revolution. Eur Urol2015; 68: 917. Google Scholar 3 : Treatment of posterior hypospadias by the autologous graft of cultured urethral epithelium. New Engl J Med1990; 323: 527. Google Scholar 4 : One-step treatment of proximal hypospadias by the autologous graft of cultured urethral epithelium. J Urol1993; 150: 1204. Link, Google Scholar 5 : Tissue-engineered buccal mucosa urethroplasty—clinical outcomes. Eur Urol2008; 53: 1263. Google Scholar 6 : Tissue-engineered autologous urethras for patients who need reconstruction: an observational study. Lancet2011; 377: 1175. Google Scholar 7 : Preclinical and clinical examination of tisssue-engineered graft for urethral reconstruction (MukoCell®) with regard to its safety. J Urol2014; 191: e122. abstract MP9-04. Link, Google Scholar 8 : Regulatory challenges for autologous tissue engineered products on their way from bench to bedside in Europe. Adv Drug Deliv Rev2015; 82-83: 181. Google Scholar 9 : Results of use of tissue-engineered autologous oral mucosa graft for urethral reconstruction: a multicenter, prospective, observational trial. EBioMedicine2017; 23: 185. Google Scholar 10 : Use of free grafts in urethral stricture reconstruction. J Urol1996; 155: 1912. Link, Google Scholar 11 : When and how to use buccal mucosal grafts in adult bulbar urethroplasty. Urology1996; 48: 194. Google Scholar 12 : Technique of harvesting buccal mucosa for urethral reconstruction. J Urol1996; 155: 1696. Link, Google Scholar 13 : Surgery Illustrated—Surgical Atlas. Ventral onlay oral mucosal graft bulbar urethroplasty. BJU Int2011; 108: 1218. Google Scholar 14 : Ventral oral mucosal onlay graft urethroplasty in nontraumatic bulbar urethral strictures: surgical technique and multivariable analysis of results in 214 patients. Eur Urol2013; 64: 440. Google Scholar 15 : Dorsal free graft urethroplasty. J Urol1996; 155: 123. Link, Google Scholar 16 : A one-stage dorsal free-graft urethroplasty for bulbar urethral strictures. Br J Urol1996; 78: 929. Google Scholar 17 : Surgery Illustrated—Surgical Atlas. Dorsal onlay oral mucosal graft bulbar urethroplasty. BJU Int2012; 109: 1728. Google Scholar 18 : The use of a dorsal buccal mucosal graft with urethral plate incision (Snodgrass) for hypospadias salvage. BJU Int1999; 83: 508. Google Scholar 19 : Dorsal free graft urethroplasty for urethral stricture by ventral sagittal urethrotomy approach. Urology2001; 58: 657. Google Scholar 20 : One-stage penile urethroplasty using oral mucosal graft and glue. Eur Urol2016; 70: 1069. Google Scholar 21 : Comparative assessment of cultures from oral and urethral stem cells for urethral regeneration. Curr Stem Cell Res Ther2016; 11: 643. Google Scholar 22 : Anterior urethra reconstruction with lateral lingual mucosa harvesting technique. Urology2016; 90: 208. Google Scholar 23 : Buccal versus lingual mucosa graft in anterior urethroplasty: a prospective comparison of surgical outcome and donor site morbidity. J Urol2016; 195: 112. Link, Google Scholar 24 : Prediction of early and late complications after oral mucosal graft harvesting: multivariable analysis from a cohort of 553 consecutive patients. J Urol2014; 191: 688. Link, Google Scholar 25 : Oral mucosa harvest for urologic reconstruction: role of maxillofacial surgeon and donor-site morbidity evaluation. J Craniofacial Surg2014; 25: 604. Google Scholar 26 : Comparison of donor site intraoral morbidity after mucosal graft harvesting for urethral reconstruction. Urology2005; 66: 716. Google Scholar 27 : The morbidity of buccal mucosal graft harvest for urethroplasty and the effect of nonclosure of the graft harvest site on postoperative pain. J Urol2004; 172: 580. Link, Google Scholar 28 : Oral complications after buccal mucosal graft harvest for urethroplasty. BJU Int2004; 94: 867. Google Scholar © 2018 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byWein A (2020) Re: Current State of Urethral Tissue EngineeringJournal of Urology, VOL. 204, NO. 1, (190-190), Online publication date: 1-Jul-2020.Barbagli G and Lazzeri M (2019) Editorial CommentJournal of Urology, VOL. 201, NO. 3, (571-571), Online publication date: 1-Mar-2019.Smith J (2018) This Month in Adult UrologyJournal of Urology, VOL. 200, NO. 2, (215-217), Online publication date: 1-Aug-2018. Volume 200Issue 2August 2018Page: 448-456 Advertisement Copyright & Permissions© 2018 by American Urological Association Education and Research, Inc.Keywordsmouth mucosamaletissue engineeringoutcome and process assessment (health care)urethral strictureurologic surgical proceduresMetricsAuthor Information Guido Barbagli Centro Chirurgico Toscano, Arezzo, Italy Equal study contribution. Financial interest and/or other relationship with UroTiss Europe. More articles by this author Ilgar Akbarov Clinic and Policlinic for Urology, University of Cologne, Cologne, Germany Equal study contribution. More articles by this author Axel Heidenreich Clinic and Policlinic for Urology, University of Cologne, Cologne, Germany More articles by this author Vahudin Zugor Clinic and Policlinic for Urology, University of Cologne, Cologne, Germany More articles by this author Roberto Olianas Department of Urology, Klinikum Lueneburg, Lueneburg, Germany More articles by this author Maurizio Aragona Department of Urology, Klinikum Lueneburg, Lueneburg, Germany More articles by this author Giuseppe Romano Urology Unit, Ospedale Santa Maria alla Gruccia, Montevarchi, Italy More articles by this author Ulf Balsmeyer Department of Urology, Zeisigwald Clinics Bethanien, Chemnitz, Germany More articles by this author Dirk Fahlenkamp Department of Urology, Zeisigwald Clinics Bethanien, Chemnitz, Germany More articles by this author Udo Rebmann Department of Urology, Diakonissen Hospital Dessau, Dessau, Germany More articles by this author Diana Standhaft Department of Urology, Diakonissen Hospital Dessau, Dessau, Germany More articles by this author Massimo Lazzeri Istituto Clinico Humanitas IRCCS, Clinical and Research Hospital, Rozzano, Italy More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
• W2794792009 created "2018-04-06" @default.
• W2794792009 creator A5010357980 @default.
• W2794792009 creator A5016667852 @default.
• W2794792009 creator A5018146967 @default.
• W2794792009 creator A5018619282 @default.
• W2794792009 creator A5020397561 @default.
• W2794792009 creator A5029496472 @default.
• W2794792009 creator A5032746256 @default.
• W2794792009 creator A5042086622 @default.
• W2794792009 creator A5048118430 @default.
• W2794792009 creator A5049837857 @default.
• W2794792009 creator A5061407189 @default.
• W2794792009 creator A5080135469 @default.
• W2794792009 date "2018-08-01" @default.
• W2794792009 modified "2023-10-09" @default.
• W2794792009 title "Anterior Urethroplasty Using a New Tissue Engineered Oral Mucosa Graft: Surgical Techniques and Outcomes" @default.
• W2794792009 cites W1522911675 @default.
• W2794792009 cites W1853384735 @default.
• W2794792009 cites W1891494489 @default.
• W2794792009 cites W1975835296 @default.
• W2794792009 cites W2006191311 @default.
• W2794792009 cites W2010396966 @default.
• W2794792009 cites W2050261573 @default.
• W2794792009 cites W2050574875 @default.
• W2794792009 cites W2067684057 @default.
• W2794792009 cites W2070988677 @default.
• W2794792009 cites W2072641766 @default.
• W2794792009 cites W2093125863 @default.
• W2794792009 cites W2103229573 @default.
• W2794792009 cites W2114336065 @default.
• W2794792009 cites W2120134337 @default.
• W2794792009 cites W2127296180 @default.
• W2794792009 cites W2127807940 @default.
• W2794792009 cites W2140273460 @default.
• W2794792009 cites W2163099048 @default.
• W2794792009 cites W2265596269 @default.
• W2794792009 cites W2279480759 @default.
• W2794792009 cites W2321308943 @default.
• W2794792009 cites W2347202509 @default.
• W2794792009 cites W2746323662 @default.
• W2794792009 cites W4242004030 @default.
• W2794792009 cites W4298232756 @default.
• W2794792009 doi "https://doi.org/10.1016/j.juro.2018.02.3102" @default.
• W2794792009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29601924" @default.
• W2794792009 hasPublicationYear "2018" @default.
• W2794792009 type Work @default.
• W2794792009 sameAs 2794792009 @default.
• W2794792009 citedByCount "42" @default.
• W2794792009 countsByYear W27947920092019 @default.
• W2794792009 countsByYear W27947920092020 @default.
• W2794792009 countsByYear W27947920092021 @default.
• W2794792009 countsByYear W27947920092022 @default.
• W2794792009 countsByYear W27947920092023 @default.
• W2794792009 crossrefType "journal-article" @default.
• W2794792009 hasAuthorship W2794792009A5010357980 @default.
• W2794792009 hasAuthorship W2794792009A5016667852 @default.
• W2794792009 hasAuthorship W2794792009A5018146967 @default.
• W2794792009 hasAuthorship W2794792009A5018619282 @default.
• W2794792009 hasAuthorship W2794792009A5020397561 @default.
• W2794792009 hasAuthorship W2794792009A5029496472 @default.
• W2794792009 hasAuthorship W2794792009A5032746256 @default.
• W2794792009 hasAuthorship W2794792009A5042086622 @default.
• W2794792009 hasAuthorship W2794792009A5048118430 @default.
• W2794792009 hasAuthorship W2794792009A5049837857 @default.
• W2794792009 hasAuthorship W2794792009A5061407189 @default.
• W2794792009 hasAuthorship W2794792009A5080135469 @default.
• W2794792009 hasConcept C141071460 @default.
• W2794792009 hasConcept C142724271 @default.
• W2794792009 hasConcept C2777085111 @default.
• W2794792009 hasConcept C2778841284 @default.
• W2794792009 hasConcept C2779409057 @default.
• W2794792009 hasConcept C2910791918 @default.
• W2794792009 hasConcept C71924100 @default.
• W2794792009 hasConceptScore W2794792009C141071460 @default.
• W2794792009 hasConceptScore W2794792009C142724271 @default.
• W2794792009 hasConceptScore W2794792009C2777085111 @default.
• W2794792009 hasConceptScore W2794792009C2778841284 @default.
• W2794792009 hasConceptScore W2794792009C2779409057 @default.
• W2794792009 hasConceptScore W2794792009C2910791918 @default.
• W2794792009 hasConceptScore W2794792009C71924100 @default.
• W2794792009 hasIssue "2" @default.
• W2794792009 hasLocation W27947920091 @default.
• W2794792009 hasLocation W27947920092 @default.
• W2794792009 hasOpenAccess W2794792009 @default.
• W2794792009 hasPrimaryLocation W27947920091 @default.
• W2794792009 hasRelatedWork W2003938723 @default.
• W2794792009 hasRelatedWork W2016468732 @default.
• W2794792009 hasRelatedWork W2047967234 @default.
• W2794792009 hasRelatedWork W2118496982 @default.
• W2794792009 hasRelatedWork W2325828725 @default.
• W2794792009 hasRelatedWork W2439875401 @default.
• W2794792009 hasRelatedWork W3022711313 @default.
• W2794792009 hasRelatedWork W4319986006 @default.
• W2794792009 hasRelatedWork W4328117130 @default.
• W2794792009 hasRelatedWork W4385231189 @default.
• W2794792009 hasVolume "200" @default.
• W2794792009 isParatext "false" @default.

• next