Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794804958> ?p ?o ?g. }
- W2794804958 endingPage "664" @default.
- W2794804958 startingPage "660" @default.
- W2794804958 abstract "Abstract Background: Appendicitis before age 20 years has been observed to influence the risk of several inflammatory conditions, possibly through underlying immunological mechanisms. Inflammation has further been suggested to be involved in prostate cancer development. We therefore hypothesized that immunological characteristics signaled by appendicitis before late adolescence might influence the risk of later prostate cancer, and aimed to evaluate this association in a population-based study. Methods: We identified a large cohort of Swedish men who underwent assessment for military conscription around the age of 18 years (n = 242,573). Medical diagnoses at time of conscription were available through the Swedish Military Conscription Register. The Swedish Cancer Register was used to identify diagnoses of prostate cancer. Multivariable adjusted Cox regression analyses were used to estimate HR and 95% confidence intervals (95% CIs) for the association between appendicitis and prostate cancer. Results: During a median of 36.7 years of follow-up, 1,684 diagnoses of prostate cancer occurred. We found a statistically significant association between appendicitis and overall prostate cancer (adjusted HR 1.70; 95% CI, 1.08–2.67). The risk was notably increased for advanced (HR 4.42; 95% CI, 1.74–11.22) and lethal (HR 8.95; 95% CI, 2.98–26.91) prostate cancer. Conclusions: These results suggest that a diagnosis of appendicitis before adulthood potentially signals underlying immune characteristics and a pattern of inflammatory response relevant to prostate cancer risk. Impact: The study lends support to the proposed role of inflammation in prostate carcinogenesis, and adds another area of investigation potentially relevant to prostate cancer development. Cancer Epidemiol Biomarkers Prev; 27(6); 660–4. ©2018 AACR." @default.
- W2794804958 created "2018-04-06" @default.
- W2794804958 creator A5000300261 @default.
- W2794804958 creator A5019030748 @default.
- W2794804958 creator A5019498765 @default.
- W2794804958 creator A5027567314 @default.
- W2794804958 creator A5028411564 @default.
- W2794804958 creator A5064461197 @default.
- W2794804958 creator A5088819461 @default.
- W2794804958 date "2018-05-31" @default.
- W2794804958 modified "2023-10-11" @default.
- W2794804958 title "Appendicitis before Age 20 Years Is Associated with an Increased Risk of Later Prostate Cancer" @default.
- W2794804958 cites W1491714528 @default.
- W2794804958 cites W1860325455 @default.
- W2794804958 cites W1898846743 @default.
- W2794804958 cites W1911919368 @default.
- W2794804958 cites W1965037168 @default.
- W2794804958 cites W1965666822 @default.
- W2794804958 cites W1972266686 @default.
- W2794804958 cites W1972739984 @default.
- W2794804958 cites W1973451208 @default.
- W2794804958 cites W1981245368 @default.
- W2794804958 cites W1987455200 @default.
- W2794804958 cites W1991938926 @default.
- W2794804958 cites W2000902052 @default.
- W2794804958 cites W2014623990 @default.
- W2794804958 cites W2044075141 @default.
- W2794804958 cites W2046594658 @default.
- W2794804958 cites W2046887204 @default.
- W2794804958 cites W2058676425 @default.
- W2794804958 cites W2059724367 @default.
- W2794804958 cites W2072814797 @default.
- W2794804958 cites W2077568042 @default.
- W2794804958 cites W2080883470 @default.
- W2794804958 cites W2082281561 @default.
- W2794804958 cites W2087137351 @default.
- W2794804958 cites W2107651796 @default.
- W2794804958 cites W2130273847 @default.
- W2794804958 cites W2131756199 @default.
- W2794804958 cites W2140780207 @default.
- W2794804958 cites W2152316289 @default.
- W2794804958 cites W2213135575 @default.
- W2794804958 cites W2296132251 @default.
- W2794804958 cites W2536910593 @default.
- W2794804958 cites W2560322684 @default.
- W2794804958 cites W2772001229 @default.
- W2794804958 doi "https://doi.org/10.1158/1055-9965.epi-17-1204" @default.
- W2794804958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29588305" @default.
- W2794804958 hasPublicationYear "2018" @default.
- W2794804958 type Work @default.
- W2794804958 sameAs 2794804958 @default.
- W2794804958 citedByCount "2" @default.
- W2794804958 countsByYear W27948049582020 @default.
- W2794804958 countsByYear W27948049582023 @default.
- W2794804958 crossrefType "journal-article" @default.
- W2794804958 hasAuthorship W2794804958A5000300261 @default.
- W2794804958 hasAuthorship W2794804958A5019030748 @default.
- W2794804958 hasAuthorship W2794804958A5019498765 @default.
- W2794804958 hasAuthorship W2794804958A5027567314 @default.
- W2794804958 hasAuthorship W2794804958A5028411564 @default.
- W2794804958 hasAuthorship W2794804958A5064461197 @default.
- W2794804958 hasAuthorship W2794804958A5088819461 @default.
- W2794804958 hasConcept C121608353 @default.
- W2794804958 hasConcept C126322002 @default.
- W2794804958 hasConcept C141071460 @default.
- W2794804958 hasConcept C143998085 @default.
- W2794804958 hasConcept C201903717 @default.
- W2794804958 hasConcept C2776235491 @default.
- W2794804958 hasConcept C2780016130 @default.
- W2794804958 hasConcept C2780192828 @default.
- W2794804958 hasConcept C2908647359 @default.
- W2794804958 hasConcept C44249647 @default.
- W2794804958 hasConcept C71924100 @default.
- W2794804958 hasConcept C99454951 @default.
- W2794804958 hasConceptScore W2794804958C121608353 @default.
- W2794804958 hasConceptScore W2794804958C126322002 @default.
- W2794804958 hasConceptScore W2794804958C141071460 @default.
- W2794804958 hasConceptScore W2794804958C143998085 @default.
- W2794804958 hasConceptScore W2794804958C201903717 @default.
- W2794804958 hasConceptScore W2794804958C2776235491 @default.
- W2794804958 hasConceptScore W2794804958C2780016130 @default.
- W2794804958 hasConceptScore W2794804958C2780192828 @default.
- W2794804958 hasConceptScore W2794804958C2908647359 @default.
- W2794804958 hasConceptScore W2794804958C44249647 @default.
- W2794804958 hasConceptScore W2794804958C71924100 @default.
- W2794804958 hasConceptScore W2794804958C99454951 @default.
- W2794804958 hasFunder F4320334630 @default.
- W2794804958 hasIssue "6" @default.
- W2794804958 hasLocation W27948049581 @default.
- W2794804958 hasLocation W27948049582 @default.
- W2794804958 hasOpenAccess W2794804958 @default.
- W2794804958 hasPrimaryLocation W27948049581 @default.
- W2794804958 hasRelatedWork W1980245127 @default.
- W2794804958 hasRelatedWork W2075763133 @default.
- W2794804958 hasRelatedWork W2088520467 @default.
- W2794804958 hasRelatedWork W2320814282 @default.
- W2794804958 hasRelatedWork W2400504790 @default.
- W2794804958 hasRelatedWork W2461239010 @default.