FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794808220> ?p ?o ?g. }

• W2794808220 abstract "AbstractBackgroundBefore data from resting-state functional magnetic resonance imaging (rs-fMRI) is analyzed, the global signal (GS) - average blood-oxygen level dependent (BOLD) signal across all voxels in the brain - is normally removed through global signal regression (GSR). This convention arose in order to control for changes in brain activity that are usually of no interest but may be caused by non-neuronal factors, including changes in respiratory rate, arterial CO2 levels or cardiac pulsation. However, recent studies have indicated that GS may systematically vary between patients with schizophrenia and healthy controls. In addition to testing this notion, we also studied if the dynamic variance of global signal across time carried any meaningful information that relates to overall symptom severity and information processing speed in patients with schizophrenia.MethodsData was collected from 39 in a clinically stable, medicated early stage of schizophrenia (median duration of illness= 6.5 years), and 34 sex, age and parental socioeconomic-status matched healthy controls over a 10-minute period of eyes-open rest at TR=2.5s (3T Philips Achieva, 240 time points, dual-echo, gradient-echo EPI). Scores were obtained from the Signs and Symptoms of Psychotic Illness (SSPI) scale and the Digit Symbol Substitution Test (DSST). Rs-fMRI time-series data were motion-corrected (using 6 parameters), slice-time corrected, reoriented with structural images, band-pass filtered (0.01–0.1 Hz), scrubbed using ArtRepair for framewise displacement and transformed to MNI space. SPM8 and the advanced version of the Data Processing Assistant for resting-state fMRI (DPARSFA) were used for this purpose. GS mean was computed from all grey matter voxels using a template mask in MNI space, using grand mean scaling to a base of 1000, averaged across all time-points. The variance of GS across time (dynamic GS variance) was computed from the entire 10-minutes of acquisition (240 time points).ResultsIndependent-sample t-tests used to compare GS mean between controls (mean[sd] = 3135.1[1244.4]) and the SCZ group (mean[sd] = 3207.8[1191.7]) yielded no significant results [t(71) = -0.14, p = .89]. The temporal variance of GS did not differ between controls (mean[sd] = 113.05[59.41]) and the SCZ group (mean[sd] = 118.02[57.93]) [t(71) = -0.36, p = .72]. In the SCZ group there was a significant correlation between the total SSPI score reflecting overall illness severity (□ = -.322, p < 0.05) and the mean GS. This relationship was especially pronounced for the syndrome of Reality Distortion (rho = -.344, p < 0.05) and Disorganization (rho = -.303, p = 0.065), where higher symptom severity was seen in patients with lower mean GS.Dynamic variance in GS was higher in healthy controls with lower mean DSST (r = -.364, p = 0.04), but no such relationship was seen in the SCZ group (r = .066, p = .694). Notably, when compared to controls (mean[sd] = 57.4[9.40]), patients (mean[sd]=42.4[9.97]) had significantly lower DSST scores [t(69) = 6.47, p < 0.001]. Neither GS nor GS variance related to root mean square of framewise displacement in the 2 groups.DiscussionWe did not find an overall increase or reduction in the global signal in patients with schizophrenia. Nevertheless, the strength of global signal obtained from resting fMRI is related to severity of persisting symptoms of schizophrenia, whereas the dynamic variance of this signal relates to the speed of processing ability assessed outside the scanner in healthy subjects. With emerging evidence relating global signal to cognitive vigilance and overall brain connectivity, our results indicate that global signal is a parameter of interest that should not be automatically discarded in resting fMRI studies of schizophrenia" @default.
• W2794808220 created "2018-04-06" @default.
• W2794808220 creator A5003372878 @default.
• W2794808220 creator A5023611909 @default.
• W2794808220 creator A5024793941 @default.
• W2794808220 creator A5036975863 @default.
• W2794808220 date "2018-04-01" @default.
• W2794808220 modified "2023-09-26" @default.
• W2794808220 title "T143. NOT A NUISANCE ANY MORE: GLOBAL FMRI SIGNAL AT REST, PROCESSING SPEED AND SYMPTOM SEVERITY IN SCHIZOPHRENIA" @default.
• W2794808220 doi "https://doi.org/10.1093/schbul/sby016.419" @default.
• W2794808220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5888431" @default.
• W2794808220 hasPublicationYear "2018" @default.
• W2794808220 type Work @default.
• W2794808220 sameAs 2794808220 @default.
• W2794808220 citedByCount "0" @default.
• W2794808220 crossrefType "journal-article" @default.
• W2794808220 hasAuthorship W2794808220A5003372878 @default.
• W2794808220 hasAuthorship W2794808220A5023611909 @default.
• W2794808220 hasAuthorship W2794808220A5024793941 @default.
• W2794808220 hasAuthorship W2794808220A5036975863 @default.
• W2794808220 hasBestOaLocation W27948082201 @default.
• W2794808220 hasConcept C118552586 @default.
• W2794808220 hasConcept C126838900 @default.
• W2794808220 hasConcept C142724271 @default.
• W2794808220 hasConcept C15744967 @default.
• W2794808220 hasConcept C169760540 @default.
• W2794808220 hasConcept C204787440 @default.
• W2794808220 hasConcept C27081682 @default.
• W2794808220 hasConcept C2776412080 @default.
• W2794808220 hasConcept C2777965283 @default.
• W2794808220 hasConcept C2779226451 @default.
• W2794808220 hasConcept C54170458 @default.
• W2794808220 hasConcept C548259974 @default.
• W2794808220 hasConcept C66324658 @default.
• W2794808220 hasConcept C71924100 @default.
• W2794808220 hasConceptScore W2794808220C118552586 @default.
• W2794808220 hasConceptScore W2794808220C126838900 @default.
• W2794808220 hasConceptScore W2794808220C142724271 @default.
• W2794808220 hasConceptScore W2794808220C15744967 @default.
• W2794808220 hasConceptScore W2794808220C169760540 @default.
• W2794808220 hasConceptScore W2794808220C204787440 @default.
• W2794808220 hasConceptScore W2794808220C27081682 @default.
• W2794808220 hasConceptScore W2794808220C2776412080 @default.
• W2794808220 hasConceptScore W2794808220C2777965283 @default.
• W2794808220 hasConceptScore W2794808220C2779226451 @default.
• W2794808220 hasConceptScore W2794808220C54170458 @default.
• W2794808220 hasConceptScore W2794808220C548259974 @default.
• W2794808220 hasConceptScore W2794808220C66324658 @default.
• W2794808220 hasConceptScore W2794808220C71924100 @default.
• W2794808220 hasLocation W27948082201 @default.
• W2794808220 hasLocation W27948082202 @default.
• W2794808220 hasLocation W27948082203 @default.
• W2794808220 hasOpenAccess W2794808220 @default.
• W2794808220 hasPrimaryLocation W27948082201 @default.
• W2794808220 hasRelatedWork W1779541997 @default.
• W2794808220 hasRelatedWork W1945001757 @default.
• W2794808220 hasRelatedWork W2001917727 @default.
• W2794808220 hasRelatedWork W2086792956 @default.
• W2794808220 hasRelatedWork W2087889032 @default.
• W2794808220 hasRelatedWork W2099152634 @default.
• W2794808220 hasRelatedWork W2134550866 @default.
• W2794808220 hasRelatedWork W2362716806 @default.
• W2794808220 hasRelatedWork W2415802646 @default.
• W2794808220 hasRelatedWork W2806783085 @default.
• W2794808220 hasRelatedWork W2954271152 @default.
• W2794808220 hasRelatedWork W3030314092 @default.
• W2794808220 hasRelatedWork W3030520831 @default.
• W2794808220 hasRelatedWork W3032826018 @default.
• W2794808220 hasRelatedWork W2189424367 @default.
• W2794808220 hasRelatedWork W2290972905 @default.
• W2794808220 hasRelatedWork W2418877941 @default.
• W2794808220 hasRelatedWork W2557025578 @default.
• W2794808220 hasRelatedWork W2785764742 @default.
• W2794808220 hasRelatedWork W2787423528 @default.
• W2794808220 isParatext "false" @default.
• W2794808220 isRetracted "false" @default.
• W2794808220 magId "2794808220" @default.
• W2794808220 workType "article" @default.