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- W2794828672 abstract "The importance of discovering new chemical transformations and/or optimizing catalytic combinations has led to a flurry of activity in reaction screening. The in situ enzymatic screening (ISES) approach described here utilizes biological tools (enzymes/cofactors) to advance chemistry. The protocol interfaces an organic reaction layer with an adjacent aqueous layer containing reporting enzymes that act upon the organic reaction product, giving rise to a spectroscopic signal. ISES allows the experimentalist to rapidly glean information on the relative rates of a set of parallel organic/organometallic reactions under investigation, without the need to quench the reactions or draw aliquots. In certain cases, the real-time enzymatic readout also provides information on sense and magnitude of enantioselectivity and substrate specificity. This article contains protocols for single-well (relative rate) and double-well (relative rate/enantiomeric excess) ISES, in addition to a colorimetric ISES protocol and a miniaturized double-well procedure. © 2017 by John Wiley & Sons, Inc." @default.
- W2794828672 created "2018-04-06" @default.
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- W2794828672 date "2017-12-01" @default.
- W2794828672 modified "2023-09-25" @default.
- W2794828672 title "The <i>In Situ</i> Enzymatic Screening (ISES) Approach to Reaction Discovery and Catalyst Identification" @default.
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- W2794828672 doi "https://doi.org/10.1002/cpch.30" @default.
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