Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794868736> ?p ?o ?g. }
- W2794868736 endingPage "777" @default.
- W2794868736 startingPage "777" @default.
- W2794868736 abstract "Despite the advances in anticancer therapies, their effectiveness for many human tumors is still far from being optimal. Significant improvements in treatment efficacy can come from the enhancement of drug specificity. This goal may be achieved by combining the use of therapeutic molecules with tumor specific effects and delivery carriers with tumor targeting ability. In this regard, nucleic acid-based drug (NABD) and particularly small interfering RNAs (siRNAs), are attractive molecules due to the possibility to be engineered to target specific tumor genes. On the other hand, polymeric-based delivery systems are emerging as versatile carriers to generate tumor-targeted delivery systems. Here we will focus on the most recent findings in the selection of siRNA/polymeric targeted delivery systems for hepatocellular carcinoma (HCC), a human tumor for which currently available therapeutic approaches are poorly effective. In addition, we will discuss the most attracting and, in our opinion, promising siRNA-polymer combinations for HCC in relation to the biological features of HCC tissue. Attention will be also put on the mathematical description of the mechanisms ruling siRNA-carrier delivery, this being an important aspect to improve effectiveness reducing the experimental work." @default.
- W2794868736 created "2018-04-06" @default.
- W2794868736 creator A5006116143 @default.
- W2794868736 creator A5006679721 @default.
- W2794868736 creator A5008348763 @default.
- W2794868736 creator A5013649375 @default.
- W2794868736 creator A5021487619 @default.
- W2794868736 creator A5023664521 @default.
- W2794868736 creator A5026204894 @default.
- W2794868736 creator A5027489759 @default.
- W2794868736 creator A5028291613 @default.
- W2794868736 creator A5029995182 @default.
- W2794868736 creator A5037422962 @default.
- W2794868736 creator A5043058962 @default.
- W2794868736 creator A5048817122 @default.
- W2794868736 creator A5058055610 @default.
- W2794868736 creator A5059192290 @default.
- W2794868736 creator A5060486063 @default.
- W2794868736 creator A5061762555 @default.
- W2794868736 creator A5061965810 @default.
- W2794868736 creator A5064046971 @default.
- W2794868736 creator A5068048791 @default.
- W2794868736 creator A5070257255 @default.
- W2794868736 creator A5072633142 @default.
- W2794868736 creator A5090062767 @default.
- W2794868736 date "2018-03-28" @default.
- W2794868736 modified "2023-10-10" @default.
- W2794868736 title "Polymer-Mediated Delivery of siRNAs to Hepatocellular Carcinoma: Variables Affecting Specificity and Effectiveness" @default.
- W2794868736 cites W1163110353 @default.
- W2794868736 cites W1490146911 @default.
- W2794868736 cites W1525867888 @default.
- W2794868736 cites W1527782622 @default.
- W2794868736 cites W155275006 @default.
- W2794868736 cites W1556987364 @default.
- W2794868736 cites W1597636635 @default.
- W2794868736 cites W1732767904 @default.
- W2794868736 cites W1749960448 @default.
- W2794868736 cites W1754823593 @default.
- W2794868736 cites W1757407923 @default.
- W2794868736 cites W175938947 @default.
- W2794868736 cites W1807210359 @default.
- W2794868736 cites W1857076294 @default.
- W2794868736 cites W1885540919 @default.
- W2794868736 cites W189780340 @default.
- W2794868736 cites W1940434397 @default.
- W2794868736 cites W1940681967 @default.
- W2794868736 cites W1963615455 @default.
- W2794868736 cites W1964837064 @default.
- W2794868736 cites W1965097716 @default.
- W2794868736 cites W1967048307 @default.
- W2794868736 cites W1968812729 @default.
- W2794868736 cites W1970944906 @default.
- W2794868736 cites W1971837077 @default.
- W2794868736 cites W1973544083 @default.
- W2794868736 cites W1973601358 @default.
- W2794868736 cites W1975154077 @default.
- W2794868736 cites W1980313235 @default.
- W2794868736 cites W1982452277 @default.
- W2794868736 cites W1982536129 @default.
- W2794868736 cites W1983383057 @default.
- W2794868736 cites W1990796256 @default.
- W2794868736 cites W1994378831 @default.
- W2794868736 cites W1994594342 @default.
- W2794868736 cites W1995237117 @default.
- W2794868736 cites W1995853527 @default.
- W2794868736 cites W1996242680 @default.
- W2794868736 cites W1997241223 @default.
- W2794868736 cites W1997882893 @default.
- W2794868736 cites W1998870247 @default.
- W2794868736 cites W1999739424 @default.
- W2794868736 cites W2000307707 @default.
- W2794868736 cites W2003155747 @default.
- W2794868736 cites W2005334224 @default.
- W2794868736 cites W2013462932 @default.
- W2794868736 cites W2015772717 @default.
- W2794868736 cites W2020223696 @default.
- W2794868736 cites W2020286391 @default.
- W2794868736 cites W2020352533 @default.
- W2794868736 cites W2024544617 @default.
- W2794868736 cites W2025036947 @default.
- W2794868736 cites W2026712967 @default.
- W2794868736 cites W2027137358 @default.
- W2794868736 cites W2027954222 @default.
- W2794868736 cites W2035110063 @default.
- W2794868736 cites W2035152288 @default.
- W2794868736 cites W2041303217 @default.
- W2794868736 cites W2046805893 @default.
- W2794868736 cites W2050889502 @default.
- W2794868736 cites W2052987547 @default.
- W2794868736 cites W2053355531 @default.
- W2794868736 cites W2056077842 @default.
- W2794868736 cites W2056109863 @default.
- W2794868736 cites W2059320976 @default.
- W2794868736 cites W2066019546 @default.
- W2794868736 cites W2068872402 @default.
- W2794868736 cites W2073365058 @default.
- W2794868736 cites W2075443995 @default.
- W2794868736 cites W2077189160 @default.