Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794877002> ?p ?o ?g. }
- W2794877002 endingPage "8403" @default.
- W2794877002 startingPage "8393" @default.
- W2794877002 abstract "Nanomaterials having enzyme-like activity (nanozymes) make them suitable candidates for various biomedical applications. In this study, we demonstrate the morphology-dependent enzyme mimetic activity of Mn3 O4 nanoparticles. It is found that Mn3 O4 nanoparticles mimic the functions of all three cellular antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Interestingly, the nanozyme activity of Mn3 O4 depends on various factors including size, morphology, surface area, and the redox properties of the metal ions. The Mn3 O4 nanoflowers exhibited remarkably high activity in all three enzyme systems and the order of multienzyme activity of different morphologies was: flowers ≫ flakes > hexagonal plates≈polyhedrons≈cubes. Interestingly, all five nanoforms are taken up by the mammalian cells and were found to be biocompatible, with very low cytotoxicity. The activity of the most active nanoflowers was studied in primary human umbilical vein endothelial cells (HUVEC) and human pulmonary microvascular endothelial cells (hPMEC) and it was found that Mn3 O4 does not reduce the level of nitric oxide (NO). This is in contrast to the effect of some of the Mn-porphyrin-based SOD mimetics, which are known to scavenge NO in endothelial cells." @default.
- W2794877002 created "2018-04-06" @default.
- W2794877002 creator A5032638949 @default.
- W2794877002 creator A5056835086 @default.
- W2794877002 creator A5059565493 @default.
- W2794877002 creator A5060977060 @default.
- W2794877002 date "2018-05-17" @default.
- W2794877002 modified "2023-10-03" @default.
- W2794877002 title "Manganese-Based Nanozymes: Multienzyme Redox Activity and Effect on the Nitric Oxide Produced by Endothelial Nitric Oxide Synthase" @default.
- W2794877002 cites W1119734502 @default.
- W2794877002 cites W1533259206 @default.
- W2794877002 cites W1560877971 @default.
- W2794877002 cites W1578984482 @default.
- W2794877002 cites W1592353488 @default.
- W2794877002 cites W1600112653 @default.
- W2794877002 cites W1966698911 @default.
- W2794877002 cites W1969887535 @default.
- W2794877002 cites W1970680007 @default.
- W2794877002 cites W1976376908 @default.
- W2794877002 cites W1976599392 @default.
- W2794877002 cites W1976652877 @default.
- W2794877002 cites W1976950210 @default.
- W2794877002 cites W1981868559 @default.
- W2794877002 cites W1982900915 @default.
- W2794877002 cites W1983937216 @default.
- W2794877002 cites W1985952890 @default.
- W2794877002 cites W1986669241 @default.
- W2794877002 cites W1987096917 @default.
- W2794877002 cites W1991691268 @default.
- W2794877002 cites W1993839684 @default.
- W2794877002 cites W1997023449 @default.
- W2794877002 cites W1997994513 @default.
- W2794877002 cites W2000887216 @default.
- W2794877002 cites W2007558846 @default.
- W2794877002 cites W2008846239 @default.
- W2794877002 cites W2014175688 @default.
- W2794877002 cites W2023099428 @default.
- W2794877002 cites W2023105087 @default.
- W2794877002 cites W2038636572 @default.
- W2794877002 cites W2040083475 @default.
- W2794877002 cites W2040339582 @default.
- W2794877002 cites W2045982598 @default.
- W2794877002 cites W2048246398 @default.
- W2794877002 cites W2049011008 @default.
- W2794877002 cites W2050269754 @default.
- W2794877002 cites W2055657360 @default.
- W2794877002 cites W2060088276 @default.
- W2794877002 cites W2064450459 @default.
- W2794877002 cites W2064872239 @default.
- W2794877002 cites W2065573460 @default.
- W2794877002 cites W2077090663 @default.
- W2794877002 cites W2083883672 @default.
- W2794877002 cites W2085850480 @default.
- W2794877002 cites W2086092293 @default.
- W2794877002 cites W2086561195 @default.
- W2794877002 cites W2089798763 @default.
- W2794877002 cites W2091193879 @default.
- W2794877002 cites W2095342832 @default.
- W2794877002 cites W2095469358 @default.
- W2794877002 cites W2102472842 @default.
- W2794877002 cites W2114238907 @default.
- W2794877002 cites W2114646867 @default.
- W2794877002 cites W2117104323 @default.
- W2794877002 cites W2120028559 @default.
- W2794877002 cites W2121280491 @default.
- W2794877002 cites W2126699352 @default.
- W2794877002 cites W2132734354 @default.
- W2794877002 cites W2139046196 @default.
- W2794877002 cites W2142813840 @default.
- W2794877002 cites W2144361706 @default.
- W2794877002 cites W2146190354 @default.
- W2794877002 cites W2147918889 @default.
- W2794877002 cites W2149369088 @default.
- W2794877002 cites W2165492152 @default.
- W2794877002 cites W2169182236 @default.
- W2794877002 cites W2170913114 @default.
- W2794877002 cites W2180470224 @default.
- W2794877002 cites W2194024578 @default.
- W2794877002 cites W2287117028 @default.
- W2794877002 cites W2296523452 @default.
- W2794877002 cites W2310415701 @default.
- W2794877002 cites W2313326603 @default.
- W2794877002 cites W2313477079 @default.
- W2794877002 cites W2319468872 @default.
- W2794877002 cites W2330791167 @default.
- W2794877002 cites W2331367727 @default.
- W2794877002 cites W2339575065 @default.
- W2794877002 cites W2400166715 @default.
- W2794877002 cites W2545364901 @default.
- W2794877002 cites W2548877147 @default.
- W2794877002 cites W2553371281 @default.
- W2794877002 cites W2756282825 @default.
- W2794877002 cites W2786474781 @default.
- W2794877002 cites W4230713761 @default.
- W2794877002 cites W4235123403 @default.
- W2794877002 cites W4247655288 @default.
- W2794877002 cites W4247794967 @default.
- W2794877002 cites W4248712489 @default.