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- W2794881638 abstract "Introduction It remains unclear whether high plasma glucose levels are associated with venous thromboembolism (VTE). This study investigated the association between fasting plasma glucose (FPG), oral glucose tolerance test (two-hour post-load plasma glucose (2HPG)), diabetes, and VTE. Materials and methods The population-based, prospective Venous thromboEmbolism In Northern Sweden (VEINS) cohort study included 108,025 residents of Västerbotten County in northern Sweden. The participants were aged 30 to 60 years and had no previous VTE events. They were included from 1985 onwards and were followed until a VTE event, death, emigration, or the study end on September 5, 2014. All underwent a health examination that measured weight, height, FPG, and 2HPG and included a questionnaire regarding smoking, education level, and history of diabetes. Potential VTE events were identified by an extensive diagnosis registry search and were validated by reviewing medical records and radiology reports. Results An objectively verified first-time VTE event was experienced by 2054 participants during 1,496,669 person-years of follow-up. In univariable analysis, there were associations between FPG, 2HPG, diabetes, and the risk of VTE. These associations disappeared after adjustment for potential confounders (age, sex, body mass index, cancer at inclusion, education level, smoking, and hypertension). The adjusted hazard ratios were 1.01 (95% confidence interval 0.83–1.23) for diabetes, 1.01 for each standard deviation of FPG (95% confidence interval 0.97–1.05), and 0.96 for each standard deviation of 2HPG (95% confidence interval 0.91–1.00). Conclusions There were no independent associations between FPG, 2HPG, diabetes, and future risk of VTE." @default.
- W2794881638 created "2018-04-06" @default.
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- W2794881638 date "2018-05-01" @default.
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- W2794881638 title "Fasting plasma glucose, oral glucose tolerance test, and the risk of first-time venous thromboembolism. A report from the VEINS cohort study." @default.
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- W2794881638 doi "https://doi.org/10.1016/j.thromres.2018.03.015" @default.
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