FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794905755> ?p ?o ?g. }

• W2794905755 endingPage "426" @default.
• W2794905755 startingPage "418" @default.
• W2794905755 abstract "Aims Gastrointestinal toxicity impedes dose escalation in chemoradiotherapy for hepatobiliary malignancies. Toxicity risk depends on clinical and radiotherapy metrics. We aimed to identify predictive factors using data from two prospective phase II clinical trials of locally advanced pancreatic cancer (LAPC). Materials and methods Ninety-one patients with available data from the ARCII (59.4 Gy in 33 fractions with gemcitabine, cisplatin and nelfinavir, n = 23) and SCALOP (50.4 Gy in 28 fractions with capecitabine or gemcitabine, n = 74) trials were studied. The independent variables analysed comprised age, sex, performance status, baseline symptoms, tumour size, weight loss, chemotherapy regimen and dose–volume histogram of stomach and duodenum in 5 Gy bins. The outcome measures used were Common Terminology Criteria of Adverse Events (CTCAE) grade and risk of CTCAE grade ≥2 acute upper gastrointestinal toxicity (anorexia, pain, nausea and/or vomiting). The risk of CTCAE grade ≥2 events was modelled using multivariable logistic regression and prediction of severity grade using ordinal regression. Results CTCAE grade ≥2 symptoms occurred in 38 patients (42%). On univariate analysis, stomach V35–45Gy was predictive of risk (odds ratio 1.035, 95% confidence interval 1.007–1.063) and grade (1.023, 1.003–1.044) of toxicity. The area under the curve was 0.632 (0.516–0.747) with toxicity risk 33/66 (50%) above and 5/25 (20%) below the optimal discriminatory threshold (7.1 cm3). Using a threshold of 30 cm3, risk was 13/20 (65%) versus 25/71 (35%). The optimal multivariable logistic regression model incorporated patient sex, chemotherapy regimen and stomach V35–45Gy. Receiving gemcitabine rather than capecitabine (odds ratio 3.965, 95% confidence interval 1.274–12.342) and weight loss during induction chemotherapy (1.216, 1.043–1.419) were significant predictors for the SCALOP cohort, whereas age predicted toxicity risk in ARCII only (1.344, 1.015–1.780). Duodenum dose–volume did not predict toxicity risk or severity in any cohort. Conclusions In chemoradiotherapy for LAPC the volume of stomach irradiated to a moderately high dose (35–45 Gy) predicts the incidence and severity of acute toxicity. Other predictive factors can include age, sex, recent weight loss and concomitant chemotherapy agents." @default.
• W2794905755 created "2018-04-06" @default.
• W2794905755 creator A5019220775 @default.
• W2794905755 creator A5030248496 @default.
• W2794905755 creator A5036198112 @default.
• W2794905755 creator A5045963430 @default.
• W2794905755 creator A5046500317 @default.
• W2794905755 creator A5067974190 @default.
• W2794905755 creator A5069947870 @default.
• W2794905755 date "2018-07-01" @default.
• W2794905755 modified "2023-10-13" @default.
• W2794905755 title "Stomach Dose–Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer" @default.
• W2794905755 cites W1933905206 @default.
• W2794905755 cites W1940632416 @default.
• W2794905755 cites W1980977417 @default.
• W2794905755 cites W1992888874 @default.
• W2794905755 cites W2001930243 @default.
• W2794905755 cites W2014247852 @default.
• W2794905755 cites W2028342615 @default.
• W2794905755 cites W2036878606 @default.
• W2794905755 cites W2040741212 @default.
• W2794905755 cites W2043945205 @default.
• W2794905755 cites W2046043778 @default.
• W2794905755 cites W2060636261 @default.
• W2794905755 cites W2074999567 @default.
• W2794905755 cites W2076668534 @default.
• W2794905755 cites W2091867909 @default.
• W2794905755 cites W2094100835 @default.
• W2794905755 cites W2104133157 @default.
• W2794905755 cites W2116168303 @default.
• W2794905755 cites W2122424036 @default.
• W2794905755 cites W2130409622 @default.
• W2794905755 cites W2141803028 @default.
• W2794905755 cites W2152575748 @default.
• W2794905755 cites W2155798267 @default.
• W2794905755 cites W2314939664 @default.
• W2794905755 cites W2339415504 @default.
• W2794905755 cites W2346921980 @default.
• W2794905755 cites W2370897425 @default.
• W2794905755 cites W2537256823 @default.
• W2794905755 cites W2621754859 @default.
• W2794905755 cites W4252572778 @default.
• W2794905755 cites W47310543 @default.
• W2794905755 doi "https://doi.org/10.1016/j.clon.2018.02.067" @default.
• W2794905755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29602584" @default.
• W2794905755 hasPublicationYear "2018" @default.
• W2794905755 type Work @default.
• W2794905755 sameAs 2794905755 @default.
• W2794905755 citedByCount "6" @default.
• W2794905755 countsByYear W27949057552019 @default.
• W2794905755 countsByYear W27949057552020 @default.
• W2794905755 countsByYear W27949057552021 @default.
• W2794905755 countsByYear W27949057552022 @default.
• W2794905755 countsByYear W27949057552023 @default.
• W2794905755 crossrefType "journal-article" @default.
• W2794905755 hasAuthorship W2794905755A5019220775 @default.
• W2794905755 hasAuthorship W2794905755A5030248496 @default.
• W2794905755 hasAuthorship W2794905755A5036198112 @default.
• W2794905755 hasAuthorship W2794905755A5045963430 @default.
• W2794905755 hasAuthorship W2794905755A5046500317 @default.
• W2794905755 hasAuthorship W2794905755A5067974190 @default.
• W2794905755 hasAuthorship W2794905755A5069947870 @default.
• W2794905755 hasBestOaLocation W27949057552 @default.
• W2794905755 hasConcept C121608353 @default.
• W2794905755 hasConcept C126322002 @default.
• W2794905755 hasConcept C141071460 @default.
• W2794905755 hasConcept C156957248 @default.
• W2794905755 hasConcept C197934379 @default.
• W2794905755 hasConcept C2777793932 @default.
• W2794905755 hasConcept C2778424827 @default.
• W2794905755 hasConcept C2780210213 @default.
• W2794905755 hasConcept C2780258809 @default.
• W2794905755 hasConcept C2780580376 @default.
• W2794905755 hasConcept C509974204 @default.
• W2794905755 hasConcept C71924100 @default.
• W2794905755 hasConcept C90924648 @default.
• W2794905755 hasConceptScore W2794905755C121608353 @default.
• W2794905755 hasConceptScore W2794905755C126322002 @default.
• W2794905755 hasConceptScore W2794905755C141071460 @default.
• W2794905755 hasConceptScore W2794905755C156957248 @default.
• W2794905755 hasConceptScore W2794905755C197934379 @default.
• W2794905755 hasConceptScore W2794905755C2777793932 @default.
• W2794905755 hasConceptScore W2794905755C2778424827 @default.
• W2794905755 hasConceptScore W2794905755C2780210213 @default.
• W2794905755 hasConceptScore W2794905755C2780258809 @default.
• W2794905755 hasConceptScore W2794905755C2780580376 @default.
• W2794905755 hasConceptScore W2794905755C509974204 @default.
• W2794905755 hasConceptScore W2794905755C71924100 @default.
• W2794905755 hasConceptScore W2794905755C90924648 @default.
• W2794905755 hasFunder F4320319985 @default.
• W2794905755 hasFunder F4320320290 @default.
• W2794905755 hasFunder F4320320350 @default.
• W2794905755 hasFunder F4320334626 @default.
• W2794905755 hasIssue "7" @default.
• W2794905755 hasLocation W27949057551 @default.
• W2794905755 hasLocation W27949057552 @default.
• W2794905755 hasOpenAccess W2794905755 @default.
• W2794905755 hasPrimaryLocation W27949057551 @default.

• next