Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794929632> ?p ?o ?g. }
- W2794929632 abstract "Abstract Metabolic profiling of cell line collections have become an invaluable tool to study disease etiology, drug modes of action and personalized medicine. However, large-scale in vitro dynamic metabolic profiling is limited by time-consuming sampling and complex measurement procedures. By adapting an MS-based metabolomics workflow for high-throughput profiling of diverse adherent mammalian cells, we establish a technique for the rapid measurement and analysis of drug-induced dynamic changes in intracellular metabolites. This methodology is scalable to large compound libraries and is here applied to study the mechanism underlying the toxic effect of dichloroacetate in ovarian cancer cell lines. System-level analysis of the metabolic responses revealed a key and unexpected role of CoA imbalance in dichloroacetate toxicity. The herein proposed strategy for large-scale drug metabolic profiling is complementary to other molecular profiling techniques, opening new scientific and drug-discovery opportunities." @default.
- W2794929632 created "2018-04-06" @default.
- W2794929632 creator A5021948285 @default.
- W2794929632 creator A5048112243 @default.
- W2794929632 creator A5054695804 @default.
- W2794929632 date "2018-01-22" @default.
- W2794929632 modified "2023-09-23" @default.
- W2794929632 title "A framework for large-scale dynamic metabolome drug profiling in mammalian cells: a case study analysis of the anti-cancer drug dichloroacetate" @default.
- W2794929632 cites W1535350845 @default.
- W2794929632 cites W1633281479 @default.
- W2794929632 cites W1707133078 @default.
- W2794929632 cites W1964895626 @default.
- W2794929632 cites W1977595804 @default.
- W2794929632 cites W1986217843 @default.
- W2794929632 cites W1989568128 @default.
- W2794929632 cites W1990693599 @default.
- W2794929632 cites W1990966191 @default.
- W2794929632 cites W1991777988 @default.
- W2794929632 cites W1993251792 @default.
- W2794929632 cites W1997995970 @default.
- W2794929632 cites W2000946696 @default.
- W2794929632 cites W2001378242 @default.
- W2794929632 cites W2002017754 @default.
- W2794929632 cites W2004908052 @default.
- W2794929632 cites W2009999719 @default.
- W2794929632 cites W2030751836 @default.
- W2794929632 cites W2037793247 @default.
- W2794929632 cites W2038009564 @default.
- W2794929632 cites W2043398720 @default.
- W2794929632 cites W2054695895 @default.
- W2794929632 cites W2063028213 @default.
- W2794929632 cites W2072249094 @default.
- W2794929632 cites W2074416258 @default.
- W2794929632 cites W2074790166 @default.
- W2794929632 cites W2075469565 @default.
- W2794929632 cites W2076272449 @default.
- W2794929632 cites W2080640178 @default.
- W2794929632 cites W2082243154 @default.
- W2794929632 cites W2082904490 @default.
- W2794929632 cites W2087312216 @default.
- W2794929632 cites W2087729559 @default.
- W2794929632 cites W2094791588 @default.
- W2794929632 cites W2104131485 @default.
- W2794929632 cites W2105381419 @default.
- W2794929632 cites W2105728643 @default.
- W2794929632 cites W2108068107 @default.
- W2794929632 cites W2108516575 @default.
- W2794929632 cites W2118217667 @default.
- W2794929632 cites W2121380625 @default.
- W2794929632 cites W2122342005 @default.
- W2794929632 cites W2124457403 @default.
- W2794929632 cites W2124673407 @default.
- W2794929632 cites W2125789330 @default.
- W2794929632 cites W2130072062 @default.
- W2794929632 cites W2132218677 @default.
- W2794929632 cites W2136079102 @default.
- W2794929632 cites W2137741805 @default.
- W2794929632 cites W2151260260 @default.
- W2794929632 cites W2159550690 @default.
- W2794929632 cites W2173348076 @default.
- W2794929632 cites W2219161659 @default.
- W2794929632 cites W2236034905 @default.
- W2794929632 cites W2272856212 @default.
- W2794929632 cites W2315313682 @default.
- W2794929632 cites W2323097244 @default.
- W2794929632 cites W2340373720 @default.
- W2794929632 cites W2346094579 @default.
- W2794929632 cites W2555338771 @default.
- W2794929632 cites W2558715006 @default.
- W2794929632 cites W2563689911 @default.
- W2794929632 cites W2563946963 @default.
- W2794929632 cites W2571021552 @default.
- W2794929632 cites W2593536290 @default.
- W2794929632 cites W2596100941 @default.
- W2794929632 cites W2609170929 @default.
- W2794929632 cites W2612467560 @default.
- W2794929632 cites W2765241646 @default.
- W2794929632 cites W2775435647 @default.
- W2794929632 cites W2791701509 @default.
- W2794929632 doi "https://doi.org/10.1101/250670" @default.
- W2794929632 hasPublicationYear "2018" @default.
- W2794929632 type Work @default.
- W2794929632 sameAs 2794929632 @default.
- W2794929632 citedByCount "1" @default.
- W2794929632 countsByYear W27949296322018 @default.
- W2794929632 crossrefType "posted-content" @default.
- W2794929632 hasAuthorship W2794929632A5021948285 @default.
- W2794929632 hasAuthorship W2794929632A5048112243 @default.
- W2794929632 hasAuthorship W2794929632A5054695804 @default.
- W2794929632 hasBestOaLocation W27949296321 @default.
- W2794929632 hasConcept C111919701 @default.
- W2794929632 hasConcept C135870905 @default.
- W2794929632 hasConcept C185592680 @default.
- W2794929632 hasConcept C187191949 @default.
- W2794929632 hasConcept C21565614 @default.
- W2794929632 hasConcept C2780035454 @default.
- W2794929632 hasConcept C41008148 @default.
- W2794929632 hasConcept C60644358 @default.
- W2794929632 hasConcept C70721500 @default.
- W2794929632 hasConcept C74187038 @default.