Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794972797> ?p ?o ?g. }
- W2794972797 endingPage "58" @default.
- W2794972797 startingPage "49" @default.
- W2794972797 abstract "Stroke patients are at increased risk for recurrent stroke and development of post-stroke dementia. In this study, we investigated the effects of recurrent stroke on adult brain neurogenesis using a novel rat model of recurrent middle cerebral artery occlusion (MCAO) developed in our laboratory. Using BrdU incorporation, activation and depletion of stem cells in the subgranular zone (SGZ) and subventricular zone (SVZ) were assessed in control rats and rats after one or two strokes. In vitro neurosphere assay was used to assess the effects of plasma from normal and stroke rats. Also, EM and permeability studies were used to evaluate changes in the blood-brain-barrier (BBB) of the SGZ after recurrent stroke. We found that proliferation and neurogenesis was activated 14 days after MCAO. This was correlated with increased permeability in the BBB to factors which increase proliferation in a neurosphere assay. However, with each stroke, there was a stepwise decrease of proliferating stem cells and impaired neurogenesis on the ipsilateral side. On the contralateral side, this process stabilized after a first stroke. These studies indicate that stem cells are activated after MCAO, possibly after increased access to systemic stroke-related factors through a leaky BBB. However, the recruitment of stem cells for neurogenesis after stroke results in a stepwise ipsilateral decline with each ischemic event, which could contribute to post-stroke dementia." @default.
- W2794972797 created "2018-04-06" @default.
- W2794972797 creator A5019645568 @default.
- W2794972797 creator A5030520665 @default.
- W2794972797 creator A5030553564 @default.
- W2794972797 creator A5036941827 @default.
- W2794972797 creator A5051627945 @default.
- W2794972797 creator A5060703553 @default.
- W2794972797 creator A5080610255 @default.
- W2794972797 creator A5084382014 @default.
- W2794972797 date "2018-07-01" @default.
- W2794972797 modified "2023-09-25" @default.
- W2794972797 title "Stepwise impairment of neural stem cell proliferation and neurogenesis concomitant with disruption of blood-brain barrier in recurrent ischemic stroke" @default.
- W2794972797 cites W1176169503 @default.
- W2794972797 cites W1480042661 @default.
- W2794972797 cites W1482674003 @default.
- W2794972797 cites W1546478791 @default.
- W2794972797 cites W1906569886 @default.
- W2794972797 cites W1964266257 @default.
- W2794972797 cites W1967076681 @default.
- W2794972797 cites W1969905245 @default.
- W2794972797 cites W1978927200 @default.
- W2794972797 cites W1979615967 @default.
- W2794972797 cites W1982076869 @default.
- W2794972797 cites W1983089266 @default.
- W2794972797 cites W1995188451 @default.
- W2794972797 cites W1997801266 @default.
- W2794972797 cites W2000835270 @default.
- W2794972797 cites W2010633131 @default.
- W2794972797 cites W2011580597 @default.
- W2794972797 cites W2021715667 @default.
- W2794972797 cites W2034275438 @default.
- W2794972797 cites W2039648938 @default.
- W2794972797 cites W2041295725 @default.
- W2794972797 cites W2041548571 @default.
- W2794972797 cites W2046006021 @default.
- W2794972797 cites W2054552572 @default.
- W2794972797 cites W2067028731 @default.
- W2794972797 cites W2070083361 @default.
- W2794972797 cites W2071252381 @default.
- W2794972797 cites W2073261075 @default.
- W2794972797 cites W2073280268 @default.
- W2794972797 cites W2074267942 @default.
- W2794972797 cites W2076016121 @default.
- W2794972797 cites W2078697459 @default.
- W2794972797 cites W2080950383 @default.
- W2794972797 cites W2081265618 @default.
- W2794972797 cites W2082360773 @default.
- W2794972797 cites W2088461838 @default.
- W2794972797 cites W2092544703 @default.
- W2794972797 cites W2099096390 @default.
- W2794972797 cites W2099395511 @default.
- W2794972797 cites W2103942647 @default.
- W2794972797 cites W2104522407 @default.
- W2794972797 cites W2106105150 @default.
- W2794972797 cites W2108340830 @default.
- W2794972797 cites W2111256919 @default.
- W2794972797 cites W2118200665 @default.
- W2794972797 cites W2125060405 @default.
- W2794972797 cites W2132823130 @default.
- W2794972797 cites W2136863044 @default.
- W2794972797 cites W2145235967 @default.
- W2794972797 cites W2151400960 @default.
- W2794972797 cites W2156077964 @default.
- W2794972797 cites W2160779535 @default.
- W2794972797 cites W2162629195 @default.
- W2794972797 cites W2163526866 @default.
- W2794972797 cites W2165224884 @default.
- W2794972797 cites W2167181354 @default.
- W2794972797 cites W2297445758 @default.
- W2794972797 cites W2402960573 @default.
- W2794972797 cites W2531150471 @default.
- W2794972797 cites W2759050422 @default.
- W2794972797 cites W4231517048 @default.
- W2794972797 doi "https://doi.org/10.1016/j.nbd.2018.03.013" @default.
- W2794972797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29605425" @default.
- W2794972797 hasPublicationYear "2018" @default.
- W2794972797 type Work @default.
- W2794972797 sameAs 2794972797 @default.
- W2794972797 citedByCount "17" @default.
- W2794972797 countsByYear W27949727972018 @default.
- W2794972797 countsByYear W27949727972019 @default.
- W2794972797 countsByYear W27949727972020 @default.
- W2794972797 countsByYear W27949727972021 @default.
- W2794972797 countsByYear W27949727972022 @default.
- W2794972797 countsByYear W27949727972023 @default.
- W2794972797 crossrefType "journal-article" @default.
- W2794972797 hasAuthorship W2794972797A5019645568 @default.
- W2794972797 hasAuthorship W2794972797A5030520665 @default.
- W2794972797 hasAuthorship W2794972797A5030553564 @default.
- W2794972797 hasAuthorship W2794972797A5036941827 @default.
- W2794972797 hasAuthorship W2794972797A5051627945 @default.
- W2794972797 hasAuthorship W2794972797A5060703553 @default.
- W2794972797 hasAuthorship W2794972797A5080610255 @default.
- W2794972797 hasAuthorship W2794972797A5084382014 @default.
- W2794972797 hasConcept C123012128 @default.
- W2794972797 hasConcept C126322002 @default.
- W2794972797 hasConcept C127413603 @default.