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- W2794984074 endingPage "24" @default.
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- W2794984074 abstract "The metabotropic glutamate receptors (mGlu receptors) are G protein-coupled receptors that bind to the excitatory neurotransmitter glutamate and are important in the modulation of neuronal excitability, synaptic transmission, and plasticity in the central nervous system. Trafficking of mGlu receptors in and out of the synaptic plasma membrane is a fundamental mechanism modulating excitatory synaptic function through regulation of receptor abundance, desensitization, and signaling profiles. In this review, we cover the regulatory mechanisms determining surface expression and endocytosis of mGlu receptors, with particular focus on post-translational modifications and receptor-protein interactions. The literature we review broadens our insight into the precise events defining the expression of functional mGlu receptors at synapses, and will likely contribute to the successful development of novel therapeutic targets for a variety of developmental, neurological, and psychiatric disorders." @default.
- W2794984074 created "2018-04-06" @default.
- W2794984074 creator A5066812726 @default.
- W2794984074 creator A5067242812 @default.
- W2794984074 creator A5071397864 @default.
- W2794984074 date "2018-09-01" @default.
- W2794984074 modified "2023-10-16" @default.
- W2794984074 title "Metabotropic glutamate receptor trafficking" @default.
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