FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794995648> ?p ?o ?g. }

• W2794995648 endingPage "e12758" @default.
• W2794995648 startingPage "e12758" @default.
• W2794995648 abstract "Exosomes are secreted into the blood by various types of cells. These extracellular vesicles are involved in the contribution of exosomal proteins to osteoblastic or osteoclastic regulatory networks during the failure of bone remodeling, which results in age-related bone loss. However, the molecular changes in serum-derived exosomes (SDEs) from aged patients with low bone density and their functions in bone remodeling remain to be fully elucidated. We present a quantitative proteomics analysis of exosomes purified from the serum of the elderly patients with osteoporosis/osteopenia and normal volunteers; these data are available via Proteome Xchange with the identifier PXD006463. Overall, 1,371 proteins were identified with an overlap of 1,160 Gene IDs among the ExoCarta proteins. Bioinformatics analysis and in vitro studies suggested that protein changes in SDEs of osteoporosis patients are not only involved in suppressing the integrin-mediated mechanosensation and activation of osteoblastic cells, but also trigger the differentiation and resorption of osteoclasts. In contrast, the main changes in SDEs of osteopenia patients facilitated both activation of osteoclasts and formation of new bone mass, which could result in a compensatory elevation in bone remodeling. While the SDEs from aged normal volunteers might play a protective role in bone health through facilitating adhesion of bone cells and suppressing aging-associated oxidative stress. This information will be helpful in elucidating the pathophysiological functions of SDEs and aid in the development of senile osteoporosis diagnostics and therapeutics." @default.
• W2794995648 created "2018-04-06" @default.
• W2794995648 creator A5006621650 @default.
• W2794995648 creator A5019623495 @default.
• W2794995648 creator A5024725065 @default.
• W2794995648 creator A5031249061 @default.
• W2794995648 creator A5038410670 @default.
• W2794995648 creator A5089282979 @default.
• W2794995648 date "2018-03-30" @default.
• W2794995648 modified "2023-10-15" @default.
• W2794995648 title "Involvement of serum-derived exosomes of elderly patients with bone loss in failure of bone remodeling via alteration of exosomal bone-related proteins" @default.
• W2794995648 cites W1750213494 @default.
• W2794995648 cites W1774931820 @default.
• W2794995648 cites W1797058518 @default.
• W2794995648 cites W1870595433 @default.
• W2794995648 cites W1950118853 @default.
• W2794995648 cites W1965184827 @default.
• W2794995648 cites W1967828169 @default.
• W2794995648 cites W1971228421 @default.
• W2794995648 cites W1988143783 @default.
• W2794995648 cites W2004943901 @default.
• W2794995648 cites W2015930249 @default.
• W2794995648 cites W2031058759 @default.
• W2794995648 cites W2042439418 @default.
• W2794995648 cites W2045438593 @default.
• W2794995648 cites W2050147422 @default.
• W2794995648 cites W2050281302 @default.
• W2794995648 cites W2064628919 @default.
• W2794995648 cites W2071791622 @default.
• W2794995648 cites W2080704715 @default.
• W2794995648 cites W2084601974 @default.
• W2794995648 cites W2091464648 @default.
• W2794995648 cites W2098259366 @default.
• W2794995648 cites W2104738334 @default.
• W2794995648 cites W2112653375 @default.
• W2794995648 cites W2114021667 @default.
• W2794995648 cites W2135581618 @default.
• W2794995648 cites W2143277993 @default.
• W2794995648 cites W2153316018 @default.
• W2794995648 cites W2170700901 @default.
• W2794995648 cites W2170852633 @default.
• W2794995648 cites W2264001446 @default.
• W2794995648 cites W2270233522 @default.
• W2794995648 cites W2299414460 @default.
• W2794995648 cites W2313290088 @default.
• W2794995648 cites W2523726707 @default.
• W2794995648 cites W2546718654 @default.
• W2794995648 cites W2549921596 @default.
• W2794995648 cites W2589694509 @default.
• W2794995648 cites W2736546079 @default.
• W2794995648 cites W93226677 @default.
• W2794995648 doi "https://doi.org/10.1111/acel.12758" @default.
• W2794995648 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5946082" @default.
• W2794995648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29603567" @default.
• W2794995648 hasPublicationYear "2018" @default.
• W2794995648 type Work @default.
• W2794995648 sameAs 2794995648 @default.
• W2794995648 citedByCount "50" @default.
• W2794995648 countsByYear W27949956482018 @default.
• W2794995648 countsByYear W27949956482019 @default.
• W2794995648 countsByYear W27949956482020 @default.
• W2794995648 countsByYear W27949956482021 @default.
• W2794995648 countsByYear W27949956482022 @default.
• W2794995648 countsByYear W27949956482023 @default.
• W2794995648 crossrefType "journal-article" @default.
• W2794995648 hasAuthorship W2794995648A5006621650 @default.
• W2794995648 hasAuthorship W2794995648A5019623495 @default.
• W2794995648 hasAuthorship W2794995648A5024725065 @default.
• W2794995648 hasAuthorship W2794995648A5031249061 @default.
• W2794995648 hasAuthorship W2794995648A5038410670 @default.
• W2794995648 hasAuthorship W2794995648A5089282979 @default.
• W2794995648 hasBestOaLocation W27949956481 @default.
• W2794995648 hasConcept C104317684 @default.
• W2794995648 hasConcept C104397665 @default.
• W2794995648 hasConcept C126322002 @default.
• W2794995648 hasConcept C134018914 @default.
• W2794995648 hasConcept C145059251 @default.
• W2794995648 hasConcept C170033053 @default.
• W2794995648 hasConcept C202751555 @default.
• W2794995648 hasConcept C203014093 @default.
• W2794995648 hasConcept C20518536 @default.
• W2794995648 hasConcept C2775843772 @default.
• W2794995648 hasConcept C2776541429 @default.
• W2794995648 hasConcept C2776886416 @default.
• W2794995648 hasConcept C2777083390 @default.
• W2794995648 hasConcept C2778260815 @default.
• W2794995648 hasConcept C2780973866 @default.
• W2794995648 hasConcept C46111723 @default.
• W2794995648 hasConcept C502942594 @default.
• W2794995648 hasConcept C55493867 @default.
• W2794995648 hasConcept C60644358 @default.
• W2794995648 hasConcept C673006 @default.
• W2794995648 hasConcept C71924100 @default.
• W2794995648 hasConcept C86803240 @default.
• W2794995648 hasConcept C95444343 @default.
• W2794995648 hasConceptScore W2794995648C104317684 @default.
• W2794995648 hasConceptScore W2794995648C104397665 @default.
• W2794995648 hasConceptScore W2794995648C126322002 @default.

• next