Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795046437> ?p ?o ?g. }
- W2795046437 endingPage "160" @default.
- W2795046437 startingPage "151" @default.
- W2795046437 abstract "Panax notoginseng saponins (PNS), extracted from rhizome of the herb Radix et Rhizoma Notoginseng (Panax notoginseng (Burk.) F.H. Chen), was recently discovered to have beneficial effects against neurological damage. This study investigated the effects of PNS on cerebral ischemia and elucidated the molecular mechanisms underlying these effects. Middle cerebral artery occlusion rats were treated with PNS (3.6 mg/100 g or 7.2 mg/100 g per day) for 7 days, the gene of LINGO-1 was measured and the expression of protein synaptophysin, postsynaptic density protein 95, LINGO-1 and p-EGFR/p-PI3K/p-AKT were investigated. The weight and mNSS score of Sprague–Dawley rats in each group were recorded every day during the 7 days. PNS promoted middle cerebral artery occlusion rats' weight and the recovery of neural function. PNS significantly decreased ischemia-induced LINGO-1 protein expression. PNS also elevated EGFR/PI3K/AKT phosphorylation levels. PNS promoted cerebral recovery from ischemic injury by accelerating synapse reconstruction and inhibiting the neuron growth negative regulatory protein LINGO-1 and activating the epidermal growth factor receptor (EGFR)/PI3K/AKT signaling pathway in vivo." @default.
- W2795046437 created "2018-04-06" @default.
- W2795046437 creator A5002696147 @default.
- W2795046437 creator A5016266625 @default.
- W2795046437 creator A5023860206 @default.
- W2795046437 creator A5028742166 @default.
- W2795046437 creator A5042505190 @default.
- W2795046437 creator A5045580230 @default.
- W2795046437 creator A5051971478 @default.
- W2795046437 creator A5059509650 @default.
- W2795046437 creator A5064489371 @default.
- W2795046437 creator A5073445421 @default.
- W2795046437 creator A5073658864 @default.
- W2795046437 creator A5078311090 @default.
- W2795046437 date "2018-04-01" @default.
- W2795046437 modified "2023-10-12" @default.
- W2795046437 title "Panax notoginseng saponins promotes cerebral recovery from ischemic injury by downregulating LINGO-1 and activating the EGFR/PI3K/AKT signaling pathways in vivo" @default.
- W2795046437 cites W1769163811 @default.
- W2795046437 cites W1908525287 @default.
- W2795046437 cites W1972871118 @default.
- W2795046437 cites W1975823659 @default.
- W2795046437 cites W1988668375 @default.
- W2795046437 cites W2003174281 @default.
- W2795046437 cites W2011729383 @default.
- W2795046437 cites W2013614177 @default.
- W2795046437 cites W2014564827 @default.
- W2795046437 cites W2020665322 @default.
- W2795046437 cites W2023367024 @default.
- W2795046437 cites W2026706584 @default.
- W2795046437 cites W2027797460 @default.
- W2795046437 cites W2037938317 @default.
- W2795046437 cites W2072300071 @default.
- W2795046437 cites W2073322731 @default.
- W2795046437 cites W2089826118 @default.
- W2795046437 cites W2112505121 @default.
- W2795046437 cites W2125619731 @default.
- W2795046437 cites W2134489725 @default.
- W2795046437 cites W2142255781 @default.
- W2795046437 cites W2149942972 @default.
- W2795046437 cites W2159195532 @default.
- W2795046437 cites W2161706084 @default.
- W2795046437 cites W2174059350 @default.
- W2795046437 cites W2174059881 @default.
- W2795046437 cites W2280063306 @default.
- W2795046437 cites W2280207065 @default.
- W2795046437 cites W2324079225 @default.
- W2795046437 cites W2384185213 @default.
- W2795046437 cites W2409903976 @default.
- W2795046437 cites W2416812336 @default.
- W2795046437 cites W2625473467 @default.
- W2795046437 doi "https://doi.org/10.1016/j.jtcms.2018.03.009" @default.
- W2795046437 hasPublicationYear "2018" @default.
- W2795046437 type Work @default.
- W2795046437 sameAs 2795046437 @default.
- W2795046437 citedByCount "4" @default.
- W2795046437 countsByYear W27950464372021 @default.
- W2795046437 countsByYear W27950464372022 @default.
- W2795046437 countsByYear W27950464372023 @default.
- W2795046437 crossrefType "journal-article" @default.
- W2795046437 hasAuthorship W2795046437A5002696147 @default.
- W2795046437 hasAuthorship W2795046437A5016266625 @default.
- W2795046437 hasAuthorship W2795046437A5023860206 @default.
- W2795046437 hasAuthorship W2795046437A5028742166 @default.
- W2795046437 hasAuthorship W2795046437A5042505190 @default.
- W2795046437 hasAuthorship W2795046437A5045580230 @default.
- W2795046437 hasAuthorship W2795046437A5051971478 @default.
- W2795046437 hasAuthorship W2795046437A5059509650 @default.
- W2795046437 hasAuthorship W2795046437A5064489371 @default.
- W2795046437 hasAuthorship W2795046437A5073445421 @default.
- W2795046437 hasAuthorship W2795046437A5073658864 @default.
- W2795046437 hasAuthorship W2795046437A5078311090 @default.
- W2795046437 hasBestOaLocation W27950464371 @default.
- W2795046437 hasConcept C126322002 @default.
- W2795046437 hasConcept C142724271 @default.
- W2795046437 hasConcept C150903083 @default.
- W2795046437 hasConcept C185592680 @default.
- W2795046437 hasConcept C204787440 @default.
- W2795046437 hasConcept C207001950 @default.
- W2795046437 hasConcept C2781212864 @default.
- W2795046437 hasConcept C541997718 @default.
- W2795046437 hasConcept C55493867 @default.
- W2795046437 hasConcept C62478195 @default.
- W2795046437 hasConcept C71924100 @default.
- W2795046437 hasConcept C75217442 @default.
- W2795046437 hasConcept C86554907 @default.
- W2795046437 hasConcept C86803240 @default.
- W2795046437 hasConcept C98274493 @default.
- W2795046437 hasConceptScore W2795046437C126322002 @default.
- W2795046437 hasConceptScore W2795046437C142724271 @default.
- W2795046437 hasConceptScore W2795046437C150903083 @default.
- W2795046437 hasConceptScore W2795046437C185592680 @default.
- W2795046437 hasConceptScore W2795046437C204787440 @default.
- W2795046437 hasConceptScore W2795046437C207001950 @default.
- W2795046437 hasConceptScore W2795046437C2781212864 @default.
- W2795046437 hasConceptScore W2795046437C541997718 @default.
- W2795046437 hasConceptScore W2795046437C55493867 @default.
- W2795046437 hasConceptScore W2795046437C62478195 @default.
- W2795046437 hasConceptScore W2795046437C71924100 @default.