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- W2795131543 abstract "Background: Major depressive disorder (MDD) is a multifactorial chronic and debilitating mood disease with high lifetime prevalence and associated with excess mortality. Treatments for this disease are not effective in all patients showing the need to find new therapeutic targets. Objective: This review aims to update our knowledge on the involvement of astroglial gap junctions and hemichannels in MDD and to show how they have become potential targets for the treatment of this pathology. Methods: The method applied in this review includes a systematic compilation of the relevant literature. Results and Conclusion: The use of rodent models of depression, gene analysis of hippocampal tissues of MDD patients and post-mortem studies on the brains from MDD patients suggest that astrocytic gap junction dysfunction may be a part of MDD etiologies. Chronic antidepressant treatments of rats, rat cultured cortical astrocytes and human astrocytoma cell lines support the hypothesis that the up-regulation of gap junctional coupling between astrocytes could be an underlying mechanism for the therapeutic effect of antidepressants. However, two recent functional studies suggest that connexin43 hemichannel activity is a part of several antidepressants’ mode of action and that astrocyte gap junctional intercellular communication and hemichannels exert different effects on antidepressant drug response. Even if they emerge as new therapeutic targets for new and more active treatments, further studies are needed to decipher the sophisticated and respective role of astrocytic gap junctions and hemichannels in MDD." @default.
- W2795131543 created "2018-04-06" @default.
- W2795131543 creator A5034270814 @default.
- W2795131543 creator A5082849305 @default.
- W2795131543 creator A5090390247 @default.
- W2795131543 date "2019-09-13" @default.
- W2795131543 modified "2023-09-30" @default.
- W2795131543 title "Targeting Gap Junctions: New Insights into the Treatment of Major Depressive Disorder" @default.
- W2795131543 cites W1249044740 @default.
- W2795131543 cites W1505571651 @default.
- W2795131543 cites W1512048841 @default.
- W2795131543 cites W1582035980 @default.
- W2795131543 cites W164388161 @default.
- W2795131543 cites W1648606954 @default.
- W2795131543 cites W1759576313 @default.
- W2795131543 cites W1843306451 @default.
- W2795131543 cites W1877874306 @default.
- W2795131543 cites W1920429098 @default.
- W2795131543 cites W1963909386 @default.
- W2795131543 cites W1965486945 @default.
- W2795131543 cites W1973093449 @default.
- W2795131543 cites W1977177662 @default.
- W2795131543 cites W1986069024 @default.
- W2795131543 cites W1987778548 @default.
- W2795131543 cites W1989488177 @default.
- W2795131543 cites W1992185997 @default.
- W2795131543 cites W1994257697 @default.
- W2795131543 cites W1995559939 @default.
- W2795131543 cites W1995916371 @default.
- W2795131543 cites W1997283068 @default.
- W2795131543 cites W2002611894 @default.
- W2795131543 cites W2005419084 @default.
- W2795131543 cites W2008544937 @default.
- W2795131543 cites W2008831180 @default.
- W2795131543 cites W2008839824 @default.
- W2795131543 cites W2008981305 @default.
- W2795131543 cites W2011101209 @default.
- W2795131543 cites W2011908808 @default.
- W2795131543 cites W2013918852 @default.
- W2795131543 cites W2014307448 @default.
- W2795131543 cites W2014471935 @default.
- W2795131543 cites W2015518484 @default.
- W2795131543 cites W2016560481 @default.
- W2795131543 cites W2016628253 @default.
- W2795131543 cites W2018194980 @default.
- W2795131543 cites W2019534872 @default.
- W2795131543 cites W2020407332 @default.
- W2795131543 cites W2021811760 @default.
- W2795131543 cites W2025485131 @default.
- W2795131543 cites W2026793904 @default.
- W2795131543 cites W2028455297 @default.
- W2795131543 cites W2030224254 @default.
- W2795131543 cites W2032505039 @default.
- W2795131543 cites W2033959160 @default.
- W2795131543 cites W2036638493 @default.
- W2795131543 cites W2036777729 @default.
- W2795131543 cites W2043588039 @default.
- W2795131543 cites W2048595403 @default.
- W2795131543 cites W2051046645 @default.
- W2795131543 cites W2053973584 @default.
- W2795131543 cites W2054695075 @default.
- W2795131543 cites W2056852922 @default.
- W2795131543 cites W2057299439 @default.
- W2795131543 cites W2059150405 @default.
- W2795131543 cites W2060938551 @default.
- W2795131543 cites W2062195428 @default.
- W2795131543 cites W2064197300 @default.
- W2795131543 cites W2065111363 @default.
- W2795131543 cites W2069035576 @default.
- W2795131543 cites W2071998818 @default.
- W2795131543 cites W2073063923 @default.
- W2795131543 cites W2073079805 @default.
- W2795131543 cites W2073715243 @default.
- W2795131543 cites W2075218913 @default.
- W2795131543 cites W2076277579 @default.
- W2795131543 cites W2079965945 @default.
- W2795131543 cites W2080103278 @default.
- W2795131543 cites W2080202616 @default.
- W2795131543 cites W2080820439 @default.
- W2795131543 cites W2081367763 @default.
- W2795131543 cites W2083217982 @default.
- W2795131543 cites W2085123274 @default.
- W2795131543 cites W2085879233 @default.
- W2795131543 cites W2086946334 @default.
- W2795131543 cites W2087363861 @default.
- W2795131543 cites W2087849583 @default.
- W2795131543 cites W2088736589 @default.
- W2795131543 cites W2089054003 @default.
- W2795131543 cites W2092046923 @default.
- W2795131543 cites W2094914362 @default.
- W2795131543 cites W2102647422 @default.
- W2795131543 cites W2105125003 @default.
- W2795131543 cites W2108437607 @default.
- W2795131543 cites W2111680565 @default.
- W2795131543 cites W2112140076 @default.
- W2795131543 cites W2112695158 @default.
- W2795131543 cites W2115434419 @default.
- W2795131543 cites W2117729213 @default.