FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795147381> ?p ?o ?g. }

• W2795147381 abstract "Abstract Post-translational modification of histones, such as histone methylation controlled by specific methyltransferases and demethylases, play critical roles in modulating chromatin dynamics and transcription in eukaryotes. Misregulation of histone methylation can lead to aberrant gene expression, thereby contributing to abnormal development and diseases such as cancer. As such, the mammalian lysine-specific demethylase 2 (KDM2) homologs, KDM2A and KDM2B, are either oncogenic or tumor suppressive, depending on specific pathological contexts. However, the role of KDM2 proteins during development in the whole organisms remains poorly understood. Unlike vertebrates, Drosophila has only one KDM2 homolog (dKDM2), but its functions in vivo remain elusive due to the complexities of the existing mutant alleles. To address this problem, we have generated two dKdm2 null alleles using the CRISPR/Cas9 technique. These dKdm2 homozygous mutants are fully viable and fertile, with no developmental defects observed under laboratory conditions. However, the dKdm2 null mutant adults display defects in circadian rhythms. Most of the dKdm2 mutants become arrhythmic under constant darkness, while the circadian period of the rhythmic mutant flies is approximately one hour shorter than the control. Interestingly, opposite defects are observed when dKDM2 is overexpressed in circadian pacemaker neurons. Taken together, these results demonstrate that dKdm2 is not essential for viability; instead, dKDM2 protein plays important roles in regulating circadian rhythms in Drosophila . Further analyses of the molecular mechanisms of how dKDM2 and its orthologs in vertebrates regulate circadian rhythms will advance our understanding of the epigenetic regulations of circadian clocks." @default.
• W2795147381 created "2018-04-06" @default.
• W2795147381 creator A5002314313 @default.
• W2795147381 creator A5035339773 @default.
• W2795147381 creator A5035659770 @default.
• W2795147381 creator A5039326076 @default.
• W2795147381 creator A5039810086 @default.
• W2795147381 creator A5040552741 @default.
• W2795147381 creator A5041559654 @default.
• W2795147381 creator A5062656720 @default.
• W2795147381 creator A5064222660 @default.
• W2795147381 creator A5075790448 @default.
• W2795147381 creator A5090399672 @default.
• W2795147381 date "2018-03-28" @default.
• W2795147381 modified "2023-09-26" @default.
• W2795147381 title "The lysine demethylase dKDM2 is non-essential for viability, but regulates circadian rhythms in Drosophila" @default.
• W2795147381 cites W1843709469 @default.
• W2795147381 cites W1855886776 @default.
• W2795147381 cites W1963789736 @default.
• W2795147381 cites W1971305813 @default.
• W2795147381 cites W1973770081 @default.
• W2795147381 cites W1974659052 @default.
• W2795147381 cites W1975472671 @default.
• W2795147381 cites W1981452104 @default.
• W2795147381 cites W1982409009 @default.
• W2795147381 cites W1983872422 @default.
• W2795147381 cites W2011482055 @default.
• W2795147381 cites W2011497273 @default.
• W2795147381 cites W2026848327 @default.
• W2795147381 cites W2028003321 @default.
• W2795147381 cites W2032668536 @default.
• W2795147381 cites W2035271418 @default.
• W2795147381 cites W2037967594 @default.
• W2795147381 cites W2054643318 @default.
• W2795147381 cites W2060712252 @default.
• W2795147381 cites W2060870400 @default.
• W2795147381 cites W2074760925 @default.
• W2795147381 cites W2082387950 @default.
• W2795147381 cites W2082959814 @default.
• W2795147381 cites W2084885369 @default.
• W2795147381 cites W2084955929 @default.
• W2795147381 cites W2092138220 @default.
• W2795147381 cites W2095111355 @default.
• W2795147381 cites W2097067381 @default.
• W2795147381 cites W2100506137 @default.
• W2795147381 cites W2111098183 @default.
• W2795147381 cites W2111771692 @default.
• W2795147381 cites W2112984940 @default.
• W2795147381 cites W2113526393 @default.
• W2795147381 cites W2123407675 @default.
• W2795147381 cites W2123552387 @default.
• W2795147381 cites W2127186571 @default.
• W2795147381 cites W2148084889 @default.
• W2795147381 cites W2154131117 @default.
• W2795147381 cites W2155259040 @default.
• W2795147381 cites W2157460414 @default.
• W2795147381 cites W2168385765 @default.
• W2795147381 cites W2171900003 @default.
• W2795147381 cites W2172085202 @default.
• W2795147381 cites W2172123465 @default.
• W2795147381 cites W2407406252 @default.
• W2795147381 cites W2442953375 @default.
• W2795147381 cites W2509664575 @default.
• W2795147381 cites W2513632107 @default.
• W2795147381 cites W2730590145 @default.
• W2795147381 cites W2755179385 @default.
• W2795147381 cites W2781902192 @default.
• W2795147381 cites W2783197792 @default.
• W2795147381 cites W4212766227 @default.
• W2795147381 cites W4245447828 @default.
• W2795147381 doi "https://doi.org/10.1101/291070" @default.
• W2795147381 hasPublicationYear "2018" @default.
• W2795147381 type Work @default.
• W2795147381 sameAs 2795147381 @default.
• W2795147381 citedByCount "0" @default.
• W2795147381 crossrefType "posted-content" @default.
• W2795147381 hasAuthorship W2795147381A5002314313 @default.
• W2795147381 hasAuthorship W2795147381A5035339773 @default.
• W2795147381 hasAuthorship W2795147381A5035659770 @default.
• W2795147381 hasAuthorship W2795147381A5039326076 @default.
• W2795147381 hasAuthorship W2795147381A5039810086 @default.
• W2795147381 hasAuthorship W2795147381A5040552741 @default.
• W2795147381 hasAuthorship W2795147381A5041559654 @default.
• W2795147381 hasAuthorship W2795147381A5062656720 @default.
• W2795147381 hasAuthorship W2795147381A5064222660 @default.
• W2795147381 hasAuthorship W2795147381A5075790448 @default.
• W2795147381 hasAuthorship W2795147381A5090399672 @default.
• W2795147381 hasBestOaLocation W27951473811 @default.
• W2795147381 hasConcept C104317684 @default.
• W2795147381 hasConcept C121446783 @default.
• W2795147381 hasConcept C143065580 @default.
• W2795147381 hasConcept C150425827 @default.
• W2795147381 hasConcept C169760540 @default.
• W2795147381 hasConcept C2780104201 @default.
• W2795147381 hasConcept C2781364455 @default.
• W2795147381 hasConcept C38606739 @default.
• W2795147381 hasConcept C41091548 @default.
• W2795147381 hasConcept C54355233 @default.
• W2795147381 hasConcept C64927066 @default.
• W2795147381 hasConcept C83640560 @default.

• next