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- W2795177170 abstract "D2 dopamine receptor-mediated suppression of synaptic transmission from interneurons plays a key role in neurobiological functions across species, ranging from respiration to memory formation. In this study, we investigated the mechanisms of D2 receptor-dependent suppression using soma-soma synapse between respiratory interneuron VD4 and LPeD1 in the mollusk Lymnaea stagnalis (L. stagnalis). We studied the effects of dopamine on voltage-dependent Ca2+ current and synaptic vesicle release from the VD4. We report that dopamine inhibits voltage-dependent Ca2+ current in the VD4 by both voltage-dependent and -independent mechanisms. Dopamine also suppresses synaptic vesicle release downstream of activity-dependent Ca2+ influx. Our study demonstrated that dopamine acts through D2 receptors to inhibit interneuron synaptic transmission through both voltage-dependent Ca2+ channel-dependent and -independent pathways. Taken together, these findings expand our understanding of dopamine function and fundamental mechanisms that shape the dynamics of neural circuit." @default.
- W2795177170 created "2018-04-06" @default.
- W2795177170 creator A5054420556 @default.
- W2795177170 creator A5070540777 @default.
- W2795177170 creator A5071323598 @default.
- W2795177170 creator A5083584728 @default.
- W2795177170 date "2018-01-01" @default.
- W2795177170 modified "2023-09-25" @default.
- W2795177170 title "Dopamine-mediated calcium channel regulation in synaptic suppression in L. stagnalis interneurons" @default.
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