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• W2795183632 abstract "Swelling of mitochondria plays an important role in the pathogenesis of human diseases by stimulating mitochondria-mediated cell death through apoptosis, necrosis, and autophagy. Changes in the permeability of the inner mitochondrial membrane (IMM) of ions and other substances induce an increase in the colloid osmotic pressure, leading to matrix swelling. Modeling of mitochondrial swelling is important for simulation and prediction of in vivo events in the cell during oxidative and energy stress. In the present study, we developed a computational model that describes the mechanism of mitochondrial swelling based on osmosis, the rigidity of the IMM, and dynamics of ionic/neutral species. The model describes a new biophysical approach to swelling dynamics, where osmotic pressure created in the matrix is compensated for by the rigidity of the IMM, i.e., osmotic pressure induces membrane deformation, which compensates for the osmotic pressure effect. Thus, the effect is linear and reversible at small membrane deformations, allowing the membrane to restore its normal form. On the other hand, the membrane rigidity drops to zero at large deformations, and the swelling becomes irreversible. As a result, an increased number of dysfunctional mitochondria can activate mitophagy and initiate cell death. Numerical modeling analysis produced results that reasonably describe the experimental data reported earlier." @default.
• W2795183632 created "2018-04-06" @default.
• W2795183632 creator A5021781197 @default.
• W2795183632 creator A5073260512 @default.
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• W2795183632 date "2018-03-28" @default.
• W2795183632 modified "2023-10-04" @default.
• W2795183632 title "Computational Modeling of In Vitro Swelling of Mitochondria: A Biophysical Approach" @default.
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• W2795183632 doi "https://doi.org/10.3390/molecules23040783" @default.
• W2795183632 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5901922" @default.
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• W2795183632 hasPublicationYear "2018" @default.
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