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- W2795195302 abstract "Abstract We sought to investigate whether magnesium oxide bound to soy protein ( MGP ) increases serum magnesium concentrations with less diarrhea compared to commonly prescribed magnesium salts. Subjects were switched to MGP at a near‐equivalent daily elemental magnesium dose. Mean serum magnesium levels were compared. If magnesium levels remained <1.7 mg/ dL after switching to MGP , subjects were enrolled into Part 2 and received a one‐time MGP dose adjustment. The MGP daily dose was increased by 266 mg. For both parts 1 and 2, subjects recorded the number and quality of their stools to assess gastrointestinal ( GI ) tolerability of MGP . Twelve pediatric kidney transplant recipients completed Part 1. Mean serum magnesium levels increased from 1.61 ( SD 0.1) on standard MG to 1.69 ( SD 0.1); t (11) = 2.6, P = .02 on MGP . Five subjects completed Part 2, and all achieved serum magnesium ≥1.7 mg/ dL (mean 1.75 mg/ dL , SD 0.06; t (4) = 2.7, P = .06). Subjects reported the same number of, but looser bowel movements with MGP ; however, individuals did not perceive intolerable GI symptoms with MGP therapy and all chose to remain on MGP at the end of the study. At an equivalent mg/kg/d dose of elemental magnesium, serum magnesium levels on MGP were significantly higher." @default.
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- W2795195302 date "2018-03-27" @default.
- W2795195302 modified "2023-10-02" @default.
- W2795195302 title "Efficacy and tolerability of magnesium plus protein for managing hypomagnesemia in pediatric kidney transplant patients" @default.
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- W2795195302 doi "https://doi.org/10.1111/petr.13170" @default.
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