Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795214849> ?p ?o ?g. }
- W2795214849 abstract "The inner membrane complex and the apical secretory organelles are defining features of apicomplexan parasites. Despite their critical roles, the mechanisms behind the biogenesis of these structures in the malaria parasite Plasmodium falciparum are still poorly defined. We here show that decreasing expression of the P. falciparum homologue of the conserved endolysomal escorter Sortilin-VPS10 prevents the formation of the inner membrane complex and abrogates the generation of new merozoites. Moreover, protein trafficking to the rhoptries, the micronemes, and the dense granules is disrupted, which leads to the accumulation of apical complex proteins in the endoplasmic reticulum and the parasitophorous vacuole. We further show that protein export to the erythrocyte and transport through the constitutive secretory pathway are functional. Taken together, our results suggest that the malaria parasite P. falciparum Sortilin has potentially broader functions than most of its other eukaryotic counterparts." @default.
- W2795214849 created "2018-04-06" @default.
- W2795214849 creator A5007824523 @default.
- W2795214849 creator A5016901614 @default.
- W2795214849 creator A5028828320 @default.
- W2795214849 creator A5043335933 @default.
- W2795214849 creator A5070181345 @default.
- W2795214849 date "2018-04-30" @default.
- W2795214849 modified "2023-10-03" @default.
- W2795214849 title "The malaria parasite <scp> <i>Plasmodium falciparum</i> </scp> Sortilin is essential for merozoite formation and apical complex biogenesis" @default.
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