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• W2795230182 abstract "Heterocyclic nucleus plays a fundamental role in the medicinal chemistry and serves as a key template for the development of various therapeutic agents including broad spectrum antibacterial drugs. In an effort to develop new antibacterial agents, a bicyclic twelve-membered heterocyclic nucleus derived from coumarin was prepared by an uncomplicated method. The rate of ring closure for this nucleus, which was given the name coumacine, in addition to two of its derivatives was monitored spectroscopically and this rate followed zero order kinetics. The chemical structures of the synthesized products were established by detecting their physicochemical properties and analyzing their IR, 1H NMR and 13C NMR spectra. The in vitro antibacterial activity of coumacines was evaluated via agar dilution method against different standard aerobic and anaerobic bacterial strains using ciprofloxacin and metronidazole as positive controls, respectively; the results indicated that coumacine I has an excellent broad spectrum antibacterial activity against the tested bacterial strains with percentage of growth inhibition approximating to those of positive controls." @default.
• W2795230182 created "2018-04-06" @default.
• W2795230182 creator A5019817672 @default.
• W2795230182 date "2018-09-01" @default.
• W2795230182 modified "2023-10-02" @default.
• W2795230182 title "Synthesis, characterization and antibacterial activity of novel heterocycle, coumacine, and two of its derivatives" @default.
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• W2795230182 doi "https://doi.org/10.1016/j.jsps.2018.03.010" @default.
• W2795230182 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6128705" @default.
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