FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795232334> ?p ?o ?g. }

• W2795232334 endingPage "17042" @default.
• W2795232334 startingPage "17028" @default.
• W2795232334 abstract "// Lissania Guerra-Calderas 1 , Rodrigo González-Barrios 1 , Carlos César Patiño 1 , Nicolás Alcaraz 4 , Marisol Salgado-Albarrán 1 , David Cantú de León 3 , Clementina Castro Hernández 1, 2 , Yesennia Sánchez-Pérez 1 , Héctor Aquiles Maldonado-Martínez 5 , Inti A. De la Rosa-Velazquez 6 , Fernanda Vargas-Romero 7 , Luis A. Herrera 1, 2 , Alejandro García-Carrancá 1, 2 and Ernesto Soto-Reyes 1 1 Cancer Biomedical Research Unit, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico 2 Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico 3 Clinical Research, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico 4 The Bioinformatics Centre, Section for RNA and Computational Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark 5 Department of Surgical Pathology, Instituto Nacional de Cancerología, Mexico City, Mexico 6 Genomics Lab, Universidad Nacional Autónoma de México, Red de Apoyo a la Investigación-CIC and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico 7 Instituto de Fisiologia Celular-Neurociencias, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City, Mexico Correspondence to: Ernesto Soto-Reyes, email: ctcf@ciencias.unam.mx Keywords: KDM4A; CTCF; histone demethylation; H3K36me; CHD5 Received: August 10, 2017      Accepted: February 26, 2018      Published: March 30, 2018 ABSTRACT Histone demethylase KDM4A is involved in H3K9me3 and H3K36me3 demethylation, which are epigenetic modifications associated with gene silencing and RNA Polymerase II elongation, respectively. KDM4A is abnormally expressed in cancer, affecting the expression of multiple targets, such as the CHD5 gene. This enzyme localizes at the first intron of CHD5 , and the dissociation of KDM4A increases gene expression. In vitro assays showed that KDM4A-mediated demethylation is enhanced in the presence of CTCF, suggesting that CTCF could increase its enzymatic activity in vivo, however the specific mechanism by which CTCF and KDM4A might be involved in the CHD5 gene repression is poorly understood. Here, we show that CTCF and KDM4A form a protein complex, which is recruited into the first intron of CHD5 . This is related to a decrease in H3K36me3/2 histone marks and is associated with its transcriptional downregulation. Depletion of CTCF or KDM4A by siRNA, triggered the reactivation of CHD5 expression, suggesting that both proteins are involved in the negative regulation of this gene. Furthermore, the knockout of KDM4A restored the CHD5 expression and H3K36me3 and H3K36me2 histone marks. Such mechanism acts independently of CHD5 promoter DNA methylation. Our findings support a novel mechanism of epigenetic repression at the gene body that does not involve promoter silencing." @default.
• W2795232334 created "2018-04-06" @default.
• W2795232334 creator A5002058356 @default.
• W2795232334 creator A5004956451 @default.
• W2795232334 creator A5010450698 @default.
• W2795232334 creator A5027304805 @default.
• W2795232334 creator A5038596389 @default.
• W2795232334 creator A5044308432 @default.
• W2795232334 creator A5049939191 @default.
• W2795232334 creator A5051110366 @default.
• W2795232334 creator A5055392184 @default.
• W2795232334 creator A5067777901 @default.
• W2795232334 creator A5075338304 @default.
• W2795232334 creator A5084541770 @default.
• W2795232334 creator A5085910142 @default.
• W2795232334 creator A5090084500 @default.
• W2795232334 date "2018-03-30" @default.
• W2795232334 modified "2023-10-18" @default.
• W2795232334 title "CTCF-KDM4A complex correlates with histone modifications that negatively regulate CHD5 gene expression in cancer cell lines" @default.
• W2795232334 cites W1560235021 @default.
• W2795232334 cites W1573839591 @default.
• W2795232334 cites W1596996643 @default.
• W2795232334 cites W1982459000 @default.
• W2795232334 cites W1983670899 @default.
• W2795232334 cites W1985180051 @default.
• W2795232334 cites W1989589242 @default.
• W2795232334 cites W2011430819 @default.
• W2795232334 cites W2013711401 @default.
• W2795232334 cites W2026776435 @default.
• W2795232334 cites W2028019479 @default.
• W2795232334 cites W2043398720 @default.
• W2795232334 cites W2044823599 @default.
• W2795232334 cites W2045203842 @default.
• W2795232334 cites W2045554354 @default.
• W2795232334 cites W2072227338 @default.
• W2795232334 cites W2087404852 @default.
• W2795232334 cites W2096083625 @default.
• W2795232334 cites W2107277218 @default.
• W2795232334 cites W2108132333 @default.
• W2795232334 cites W2118540634 @default.
• W2795232334 cites W2121533951 @default.
• W2795232334 cites W2121540480 @default.
• W2795232334 cites W2123552387 @default.
• W2795232334 cites W2127988376 @default.
• W2795232334 cites W2130983930 @default.
• W2795232334 cites W2133332261 @default.
• W2795232334 cites W2141452262 @default.
• W2795232334 cites W2141567062 @default.
• W2795232334 cites W2145056743 @default.
• W2795232334 cites W2146611000 @default.
• W2795232334 cites W2149710757 @default.
• W2795232334 cites W2149864958 @default.
• W2795232334 cites W2150085673 @default.
• W2795232334 cites W2162463195 @default.
• W2795232334 cites W2167325961 @default.
• W2795232334 cites W2172174991 @default.
• W2795232334 cites W2192080449 @default.
• W2795232334 cites W2340416979 @default.
• W2795232334 cites W2397665981 @default.
• W2795232334 cites W2415637561 @default.
• W2795232334 cites W2510569157 @default.
• W2795232334 cites W2536112707 @default.
• W2795232334 doi "https://doi.org/10.18632/oncotarget.24798" @default.
• W2795232334 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5908303" @default.
• W2795232334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29682202" @default.
• W2795232334 hasPublicationYear "2018" @default.
• W2795232334 type Work @default.
• W2795232334 sameAs 2795232334 @default.
• W2795232334 citedByCount "7" @default.
• W2795232334 countsByYear W27952323342019 @default.
• W2795232334 countsByYear W27952323342021 @default.
• W2795232334 countsByYear W27952323342022 @default.
• W2795232334 countsByYear W27952323342023 @default.
• W2795232334 crossrefType "journal-article" @default.
• W2795232334 hasAuthorship W2795232334A5002058356 @default.
• W2795232334 hasAuthorship W2795232334A5004956451 @default.
• W2795232334 hasAuthorship W2795232334A5010450698 @default.
• W2795232334 hasAuthorship W2795232334A5027304805 @default.
• W2795232334 hasAuthorship W2795232334A5038596389 @default.
• W2795232334 hasAuthorship W2795232334A5044308432 @default.
• W2795232334 hasAuthorship W2795232334A5049939191 @default.
• W2795232334 hasAuthorship W2795232334A5051110366 @default.
• W2795232334 hasAuthorship W2795232334A5055392184 @default.
• W2795232334 hasAuthorship W2795232334A5067777901 @default.
• W2795232334 hasAuthorship W2795232334A5075338304 @default.
• W2795232334 hasAuthorship W2795232334A5084541770 @default.
• W2795232334 hasAuthorship W2795232334A5085910142 @default.
• W2795232334 hasAuthorship W2795232334A5090084500 @default.
• W2795232334 hasBestOaLocation W27952323341 @default.
• W2795232334 hasConcept C104317684 @default.
• W2795232334 hasConcept C111936080 @default.
• W2795232334 hasConcept C142362112 @default.
• W2795232334 hasConcept C150194340 @default.
• W2795232334 hasConcept C15708023 @default.
• W2795232334 hasConcept C2778760011 @default.
• W2795232334 hasConcept C3019520520 @default.
• W2795232334 hasConcept C54355233 @default.
• W2795232334 hasConcept C86803240 @default.

• next