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• W2795269319 endingPage "110" @default.
• W2795269319 startingPage "96" @default.
• W2795269319 abstract "Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. Its emerging role as an effector of innate immunity is affirmed by mutations in the SAMHD1 gene that cause the severe autoimmune disease, Aicardi–Goutieres syndrome (AGS) and that are linked to cancer. Additionally, SAMHD1 functions as a restriction factor for retroviruses, such as HIV. Here, we review the current biochemical and biological properties of the enzyme including its structure, activity, and regulation by post-translational modifications in the context of its cellular function. We outline open questions regarding the biology of SAMHD1 whose answers will be important for understanding its function as a regulator of cell cycle progression, genomic integrity, and in autoimmunity." @default.
• W2795269319 created "2018-04-06" @default.
• W2795269319 creator A5009964853 @default.
• W2795269319 creator A5068080472 @default.
• W2795269319 date "2018-03-27" @default.
• W2795269319 modified "2023-09-30" @default.
• W2795269319 title "SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity" @default.
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