Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795295890> ?p ?o ?g. }
- W2795295890 endingPage "12" @default.
- W2795295890 startingPage "1" @default.
- W2795295890 abstract "Valvular heart disease is an increasing population health problem and, especially in the elderly, a significant cause of morbidity and mortality. The current treatment options, such as mechanical and bioprosthetic heart valve replacements, have significant restrictions and limitations. Considering the increased life expectancy of our aging population, there is an urgent need for novel heart valve concepts that remain functional throughout life to prevent the need for reoperation. Heart valve tissue engineering aims to overcome these constraints by creating regenerative, self-repairing valve substitutes with life-long durability. In this review, we give an overview of advances in the development of tissue engineered heart valves, and describe the steps required to design and validate a novel valve prosthesis before reaching first-in-men clinical trials. In-silico and in-vitro models are proposed as tools for the assessment of valve design, functionality and compatibility, while in-vivo preclinical models are required to confirm the remodeling and growth potential of the tissue engineered heart valves. An overview of the tissue engineered heart valve studies that have reached clinical translation is also presented. Final remarks highlight the possibilities as well as the obstacles to overcome in translating heart valve prostheses into clinical application." @default.
- W2795295890 created "2018-04-06" @default.
- W2795295890 creator A5002240288 @default.
- W2795295890 creator A5028898070 @default.
- W2795295890 creator A5037978981 @default.
- W2795295890 creator A5044123558 @default.
- W2795295890 creator A5050885216 @default.
- W2795295890 creator A5087731542 @default.
- W2795295890 date "2019-03-01" @default.
- W2795295890 modified "2023-09-26" @default.
- W2795295890 title "Cardiovascular tissue engineering: From basic science to clinical application" @default.
- W2795295890 cites W1522824862 @default.
- W2795295890 cites W1556929109 @default.
- W2795295890 cites W1701669187 @default.
- W2795295890 cites W1707040081 @default.
- W2795295890 cites W1748854780 @default.
- W2795295890 cites W1783104208 @default.
- W2795295890 cites W1893246933 @default.
- W2795295890 cites W1907236337 @default.
- W2795295890 cites W1908289777 @default.
- W2795295890 cites W1912859159 @default.
- W2795295890 cites W1968185759 @default.
- W2795295890 cites W1970066841 @default.
- W2795295890 cites W1970600939 @default.
- W2795295890 cites W1972044372 @default.
- W2795295890 cites W1974493691 @default.
- W2795295890 cites W1975072818 @default.
- W2795295890 cites W1975208950 @default.
- W2795295890 cites W1976731618 @default.
- W2795295890 cites W1984737945 @default.
- W2795295890 cites W1989491027 @default.
- W2795295890 cites W1993121929 @default.
- W2795295890 cites W1995063875 @default.
- W2795295890 cites W2001002046 @default.
- W2795295890 cites W2007142909 @default.
- W2795295890 cites W2022962657 @default.
- W2795295890 cites W2024496703 @default.
- W2795295890 cites W2028945965 @default.
- W2795295890 cites W2031726511 @default.
- W2795295890 cites W2041187001 @default.
- W2795295890 cites W2041617439 @default.
- W2795295890 cites W2044952091 @default.
- W2795295890 cites W2046385728 @default.
- W2795295890 cites W2052700508 @default.
- W2795295890 cites W2056199796 @default.
- W2795295890 cites W2060725450 @default.
- W2795295890 cites W2063418551 @default.
- W2795295890 cites W2065678169 @default.
- W2795295890 cites W2069097422 @default.
- W2795295890 cites W2069231754 @default.
- W2795295890 cites W2070014830 @default.
- W2795295890 cites W2072868907 @default.
- W2795295890 cites W2074814160 @default.
- W2795295890 cites W2075604516 @default.
- W2795295890 cites W2078641461 @default.
- W2795295890 cites W2082013410 @default.
- W2795295890 cites W2087364511 @default.
- W2795295890 cites W2087417971 @default.
- W2795295890 cites W2087773329 @default.
- W2795295890 cites W2088052594 @default.
- W2795295890 cites W2089844652 @default.
- W2795295890 cites W2089880298 @default.
- W2795295890 cites W2090028890 @default.
- W2795295890 cites W2096234854 @default.
- W2795295890 cites W2097256302 @default.
- W2795295890 cites W2105659895 @default.
- W2795295890 cites W2108651041 @default.
- W2795295890 cites W2111403908 @default.
- W2795295890 cites W2112050863 @default.
- W2795295890 cites W2122694177 @default.
- W2795295890 cites W2125261131 @default.
- W2795295890 cites W2126045345 @default.
- W2795295890 cites W2133923417 @default.
- W2795295890 cites W2134328973 @default.
- W2795295890 cites W2135062381 @default.
- W2795295890 cites W2135081194 @default.
- W2795295890 cites W2135412352 @default.
- W2795295890 cites W2138321247 @default.
- W2795295890 cites W2139926289 @default.
- W2795295890 cites W2144053259 @default.
- W2795295890 cites W2144740404 @default.
- W2795295890 cites W2148633433 @default.
- W2795295890 cites W2151472224 @default.
- W2795295890 cites W2153640696 @default.
- W2795295890 cites W2161411353 @default.
- W2795295890 cites W2164084043 @default.
- W2795295890 cites W2169052697 @default.
- W2795295890 cites W2172897761 @default.
- W2795295890 cites W2277824627 @default.
- W2795295890 cites W2310774765 @default.
- W2795295890 cites W2324520536 @default.
- W2795295890 cites W2328103304 @default.
- W2795295890 cites W2340340396 @default.
- W2795295890 cites W2342604115 @default.
- W2795295890 cites W2342617146 @default.
- W2795295890 cites W2360144314 @default.
- W2795295890 cites W2402096476 @default.
- W2795295890 cites W2410954360 @default.