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- W2795362411 abstract "Neurotoxic and cytotoxic effects of venoms from Scorpio maurus palmatus taken fromdifferent populations were assessed for geographic based variability in toxicity, and toevaluate their insecticidal potency. Scorpions were collected from four regions. Threelocations were mutually isolated pockets in the arid area of Southern Sinai. The fourthsample was collected from a population inhabiting the semi-arid environment ofWestern Mediterranean Coastal Desert. The neurotoxic (paralytic) effect of the venomfrom each population was assayed by its ability to induce permanent disability in adultcockroaches within 3 h. Venom was applied using microinjection techniques through anintersegmental membrane. Probit analysis was used to calculate the Paralytic EffectiveDose (PED50, ng/100 mg). Levels of glutathione, lipid peroxidation, protein carbonylcontent and nitric oxide, as well as the activities of superoxide dismutase, catalase andcholinesterase, were measured to assess the cytotoxicity of the venom. The results showthat the injected venom from each population induced obvious spasticity, followed byflaccid paralysis. All the tested biochemical parameters, except glutathione content,revealed significant differences in toxicity in venom taken from the different scorpionpopulations. We conclude that (i) the venom of this scorpion has significant neurotoxicand cytotoxic effects on insect cells, (ii) its efficacy, as assessed by the PED50 unit,exhibited variation across its geographic range, and (iii) components in the venom mayhave the potential for being developed into effective and environmentally friendlybioinsecticides." @default.
- W2795362411 created "2018-04-06" @default.
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- W2795362411 date "2010-01-01" @default.
- W2795362411 modified "2023-09-28" @default.
- W2795362411 title "Neurotoxic and cytotoxic effects of venom from different populations" @default.
- W2795362411 hasPublicationYear "2010" @default.
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