Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795372016> ?p ?o ?g. }
- W2795372016 endingPage "531" @default.
- W2795372016 startingPage "523" @default.
- W2795372016 abstract "Mapping free-energy landscapes has proved to be a powerful tool for studying reaction mechanisms. Many complex biomolecular assembly processes, however, have remained challenging to access using this approach, including the aggregation of peptides and proteins into amyloid fibrils implicated in a range of disorders. Here, we generalize the strategy used to probe free-energy landscapes in protein folding to determine the activation energies and entropies that characterize each of the molecular steps in the aggregation of the amyloid-β peptide (Aβ42), which is associated with Alzheimer's disease. Our results reveal that interactions between monomeric Aβ42 and amyloid fibrils during fibril-dependent secondary nucleation fundamentally reverse the thermodynamic signature of this process relative to primary nucleation, even though both processes generate aggregates from soluble peptides. By mapping the energetic and entropic contributions along the reaction trajectories, we show that the catalytic efficiency of Aβ42 fibril surfaces results from the enthalpic stabilization of adsorbing peptides in conformations amenable to nucleation, resulting in a dramatic lowering of the activation energy for nucleation." @default.
- W2795372016 created "2018-04-13" @default.
- W2795372016 creator A5006551440 @default.
- W2795372016 creator A5006983623 @default.
- W2795372016 creator A5012909190 @default.
- W2795372016 creator A5025044814 @default.
- W2795372016 creator A5038452125 @default.
- W2795372016 creator A5041530719 @default.
- W2795372016 creator A5046590506 @default.
- W2795372016 creator A5070625264 @default.
- W2795372016 creator A5077700394 @default.
- W2795372016 date "2018-03-26" @default.
- W2795372016 modified "2023-10-03" @default.
- W2795372016 title "Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide" @default.
- W2795372016 cites W1481393922 @default.
- W2795372016 cites W1797763128 @default.
- W2795372016 cites W1973897761 @default.
- W2795372016 cites W1979863594 @default.
- W2795372016 cites W1980825524 @default.
- W2795372016 cites W1983254345 @default.
- W2795372016 cites W1999556234 @default.
- W2795372016 cites W2024691049 @default.
- W2795372016 cites W2025336895 @default.
- W2795372016 cites W2025607001 @default.
- W2795372016 cites W2030325989 @default.
- W2795372016 cites W2034147064 @default.
- W2795372016 cites W2041505869 @default.
- W2795372016 cites W2042214383 @default.
- W2795372016 cites W2049421402 @default.
- W2795372016 cites W2050207511 @default.
- W2795372016 cites W2050375429 @default.
- W2795372016 cites W2056785199 @default.
- W2795372016 cites W2057673048 @default.
- W2795372016 cites W2059804089 @default.
- W2795372016 cites W2061657038 @default.
- W2795372016 cites W2062784336 @default.
- W2795372016 cites W2068334126 @default.
- W2795372016 cites W2069350490 @default.
- W2795372016 cites W2085266415 @default.
- W2795372016 cites W2088577455 @default.
- W2795372016 cites W2093861673 @default.
- W2795372016 cites W2094881767 @default.
- W2795372016 cites W2113148965 @default.
- W2795372016 cites W2114471971 @default.
- W2795372016 cites W2121963977 @default.
- W2795372016 cites W2122294662 @default.
- W2795372016 cites W2122814674 @default.
- W2795372016 cites W2131268816 @default.
- W2795372016 cites W2134178829 @default.
- W2795372016 cites W2141852179 @default.
- W2795372016 cites W2150999725 @default.
- W2795372016 cites W2156700271 @default.
- W2795372016 cites W2158476854 @default.
- W2795372016 cites W2165186407 @default.
- W2795372016 cites W2331617680 @default.
- W2795372016 cites W2482248702 @default.
- W2795372016 cites W2763455835 @default.
- W2795372016 cites W3098135064 @default.
- W2795372016 cites W4241070305 @default.
- W2795372016 cites W566353445 @default.
- W2795372016 doi "https://doi.org/10.1038/s41557-018-0023-x" @default.
- W2795372016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5911155" @default.
- W2795372016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29581486" @default.
- W2795372016 hasPublicationYear "2018" @default.
- W2795372016 type Work @default.
- W2795372016 sameAs 2795372016 @default.
- W2795372016 citedByCount "117" @default.
- W2795372016 countsByYear W27953720162018 @default.
- W2795372016 countsByYear W27953720162019 @default.
- W2795372016 countsByYear W27953720162020 @default.
- W2795372016 countsByYear W27953720162021 @default.
- W2795372016 countsByYear W27953720162022 @default.
- W2795372016 countsByYear W27953720162023 @default.
- W2795372016 crossrefType "journal-article" @default.
- W2795372016 hasAuthorship W2795372016A5006551440 @default.
- W2795372016 hasAuthorship W2795372016A5006983623 @default.
- W2795372016 hasAuthorship W2795372016A5012909190 @default.
- W2795372016 hasAuthorship W2795372016A5025044814 @default.
- W2795372016 hasAuthorship W2795372016A5038452125 @default.
- W2795372016 hasAuthorship W2795372016A5041530719 @default.
- W2795372016 hasAuthorship W2795372016A5046590506 @default.
- W2795372016 hasAuthorship W2795372016A5070625264 @default.
- W2795372016 hasAuthorship W2795372016A5077700394 @default.
- W2795372016 hasBestOaLocation W27953720162 @default.
- W2795372016 hasConcept C119599485 @default.
- W2795372016 hasConcept C119621388 @default.
- W2795372016 hasConcept C12554922 @default.
- W2795372016 hasConcept C127413603 @default.
- W2795372016 hasConcept C136238340 @default.
- W2795372016 hasConcept C142724271 @default.
- W2795372016 hasConcept C166940927 @default.
- W2795372016 hasConcept C178790620 @default.
- W2795372016 hasConcept C179104552 @default.
- W2795372016 hasConcept C185592680 @default.
- W2795372016 hasConcept C204328495 @default.
- W2795372016 hasConcept C27523624 @default.
- W2795372016 hasConcept C2776545253 @default.
- W2795372016 hasConcept C2777633098 @default.