FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795431931> ?p ?o ?g. }

• W2795431931 abstract "Abstract It is widely assumed that cells must be physically isolated to study their molecular profiles. However, intact tissue samples naturally exhibit variation in cellular composition, which drives covariation of cell-class-specific molecular features. By analyzing transcriptional covariation in 7221 intact CNS samples from 840 individuals representing billions of cells, we reveal the core transcriptional identities of major CNS cell classes in humans. By modeling intact CNS transcriptomes as a function of variation in cellular composition, we identify cell-class-specific transcriptional differences in Alzheimer’s disease, among brain regions, and between species. Among these, we show that PMP2 is expressed by human but not mouse astrocytes and significantly increases mouse astrocyte size upon ectopic expression in vivo, causing them to more closely resemble their human counterparts. Our work is available as an online resource ( http://oldhamlab.ctec.ucsf.edu ) and provides a generalizable strategy for determining the core molecular features of cellular identity in intact biological systems." @default.
• W2795431931 created "2018-04-13" @default.
• W2795431931 creator A5007271966 @default.
• W2795431931 creator A5050211410 @default.
• W2795431931 creator A5066524408 @default.
• W2795431931 creator A5077155003 @default.
• W2795431931 date "2018-02-14" @default.
• W2795431931 modified "2023-09-29" @default.
• W2795431931 title "Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes" @default.
• W2795431931 cites W1533942137 @default.
• W2795431931 cites W1552434751 @default.
• W2795431931 cites W175813982 @default.
• W2795431931 cites W1944486417 @default.
• W2795431931 cites W1964895626 @default.
• W2795431931 cites W1966327575 @default.
• W2795431931 cites W1989119979 @default.
• W2795431931 cites W2022689242 @default.
• W2795431931 cites W2027764072 @default.
• W2795431931 cites W2033105784 @default.
• W2795431931 cites W2054275187 @default.
• W2795431931 cites W2072673499 @default.
• W2795431931 cites W2076686768 @default.
• W2795431931 cites W2081837126 @default.
• W2795431931 cites W2082807958 @default.
• W2795431931 cites W2087093188 @default.
• W2795431931 cites W2093358653 @default.
• W2795431931 cites W2094379190 @default.
• W2795431931 cites W2096173332 @default.
• W2795431931 cites W2114926230 @default.
• W2795431931 cites W2115521875 @default.
• W2795431931 cites W2115746733 @default.
• W2795431931 cites W2117266418 @default.
• W2795431931 cites W2118661818 @default.
• W2795431931 cites W2123491442 @default.
• W2795431931 cites W2124940469 @default.
• W2795431931 cites W2131273916 @default.
• W2795431931 cites W2141991780 @default.
• W2795431931 cites W2147270524 @default.
• W2795431931 cites W2150730731 @default.
• W2795431931 cites W2160748841 @default.
• W2795431931 cites W2163410184 @default.
• W2795431931 cites W2191292005 @default.
• W2795431931 cites W2231058499 @default.
• W2795431931 cites W2256016639 @default.
• W2795431931 cites W2260830658 @default.
• W2795431931 cites W2288153033 @default.
• W2795431931 cites W2471513101 @default.
• W2795431931 cites W2472012926 @default.
• W2795431931 cites W2747841296 @default.
• W2795431931 doi "https://doi.org/10.1101/265397" @default.
• W2795431931 hasPublicationYear "2018" @default.
• W2795431931 type Work @default.
• W2795431931 sameAs 2795431931 @default.
• W2795431931 citedByCount "3" @default.
• W2795431931 countsByYear W27954319312018 @default.
• W2795431931 countsByYear W27954319312019 @default.
• W2795431931 countsByYear W27954319312020 @default.
• W2795431931 crossrefType "posted-content" @default.
• W2795431931 hasAuthorship W2795431931A5007271966 @default.
• W2795431931 hasAuthorship W2795431931A5050211410 @default.
• W2795431931 hasAuthorship W2795431931A5066524408 @default.
• W2795431931 hasAuthorship W2795431931A5077155003 @default.
• W2795431931 hasBestOaLocation W27954319311 @default.
• W2795431931 hasConcept C104317684 @default.
• W2795431931 hasConcept C14036430 @default.
• W2795431931 hasConcept C1491633281 @default.
• W2795431931 hasConcept C150194340 @default.
• W2795431931 hasConcept C162317418 @default.
• W2795431931 hasConcept C169760540 @default.
• W2795431931 hasConcept C189014844 @default.
• W2795431931 hasConcept C2777542381 @default.
• W2795431931 hasConcept C2777670902 @default.
• W2795431931 hasConcept C529278444 @default.
• W2795431931 hasConcept C54355233 @default.
• W2795431931 hasConcept C70721500 @default.
• W2795431931 hasConcept C86803240 @default.
• W2795431931 hasConcept C95444343 @default.
• W2795431931 hasConcept C97037327 @default.
• W2795431931 hasConceptScore W2795431931C104317684 @default.
• W2795431931 hasConceptScore W2795431931C14036430 @default.
• W2795431931 hasConceptScore W2795431931C1491633281 @default.
• W2795431931 hasConceptScore W2795431931C150194340 @default.
• W2795431931 hasConceptScore W2795431931C162317418 @default.
• W2795431931 hasConceptScore W2795431931C169760540 @default.
• W2795431931 hasConceptScore W2795431931C189014844 @default.
• W2795431931 hasConceptScore W2795431931C2777542381 @default.
• W2795431931 hasConceptScore W2795431931C2777670902 @default.
• W2795431931 hasConceptScore W2795431931C529278444 @default.
• W2795431931 hasConceptScore W2795431931C54355233 @default.
• W2795431931 hasConceptScore W2795431931C70721500 @default.
• W2795431931 hasConceptScore W2795431931C86803240 @default.
• W2795431931 hasConceptScore W2795431931C95444343 @default.
• W2795431931 hasConceptScore W2795431931C97037327 @default.
• W2795431931 hasLocation W27954319311 @default.
• W2795431931 hasLocation W27954319312 @default.
• W2795431931 hasOpenAccess W2795431931 @default.
• W2795431931 hasPrimaryLocation W27954319311 @default.
• W2795431931 hasRelatedWork W2236023326 @default.
• W2795431931 hasRelatedWork W2601723752 @default.
• W2795431931 hasRelatedWork W2886018100 @default.

• next