FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795432914> ?p ?o ?g. }

• W2795432914 endingPage "2091" @default.
• W2795432914 startingPage "2079" @default.
• W2795432914 abstract "Drug delivery systems (DDS) and their interaction with cells are a controversial topic in the development of therapeutic concepts and approaches. On one hand, DDS are very useful for protected and targeted transport of defined dosages of active agents. On the other hand, their physicochemical properties such as material, size, shape, charge, or stiffness have a huge impact on cellular uptake and intracellular processing. Additionally, even identical DDS can undergo a completely diverse interaction with different cell types. However, quite often in in vitro DDS/cell interaction experiments, those aspects are not considered and DDS and cells are randomly chosen.Hence, our investigations provide an insight into layer-by-layer designed microcarriers with modifications of only some of the most important parameters (surface charge, stiffness, and applied microcarrier/cell ratio) and their influence on cellular uptake and viability. We also considered the interaction of these differently equipped DDS with several cell types and investigated professional phagocytes (neutrophil granulocytes; macrophages) as well as non-professional phagocytes (epithelial cells) under comparable conditions. We found that even small modifications such as layer-by-layer (LbL)-microcarriers with positive or negative surface charge, or LbL-microcarriers with solid core or as hollow capsules but equipped with the same surface properties, show significant differences in interaction and viability, and several cell types react very differently to the offered DDS.As a consequence, the properties of the DDS have to be carefully chosen with respect to the addressed cell type with the aim to efficiently transport a desired agent." @default.
• W2795432914 created "2018-04-13" @default.
• W2795432914 creator A5028480925 @default.
• W2795432914 creator A5064925595 @default.
• W2795432914 creator A5078788252 @default.
• W2795432914 creator A5091719257 @default.
• W2795432914 date "2018-04-01" @default.
• W2795432914 modified "2023-09-25" @default.
• W2795432914 title "Cellular interaction of a layer-by-layer based drug delivery system depending on material properties and cell types" @default.
• W2795432914 cites W126890139 @default.
• W2795432914 cites W1515068677 @default.
• W2795432914 cites W1556776339 @default.
• W2795432914 cites W1592617873 @default.
• W2795432914 cites W1964746125 @default.
• W2795432914 cites W1970046408 @default.
• W2795432914 cites W1989589742 @default.
• W2795432914 cites W1993776480 @default.
• W2795432914 cites W1996041620 @default.
• W2795432914 cites W2002392659 @default.
• W2795432914 cites W2012415189 @default.
• W2795432914 cites W2016097990 @default.
• W2795432914 cites W2025868400 @default.
• W2795432914 cites W2029490817 @default.
• W2795432914 cites W2046565260 @default.
• W2795432914 cites W2048736491 @default.
• W2795432914 cites W2048878719 @default.
• W2795432914 cites W2056320287 @default.
• W2795432914 cites W2059014740 @default.
• W2795432914 cites W2073431045 @default.
• W2795432914 cites W2085359703 @default.
• W2795432914 cites W2086069830 @default.
• W2795432914 cites W2097840191 @default.
• W2795432914 cites W2126184258 @default.
• W2795432914 cites W2153962966 @default.
• W2795432914 cites W2163428285 @default.
• W2795432914 cites W2271636378 @default.
• W2795432914 cites W2428285903 @default.
• W2795432914 doi "https://doi.org/10.2147/ijn.s153701" @default.
• W2795432914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5896659" @default.
• W2795432914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29670351" @default.
• W2795432914 hasPublicationYear "2018" @default.
• W2795432914 type Work @default.
• W2795432914 sameAs 2795432914 @default.
• W2795432914 citedByCount "12" @default.
• W2795432914 countsByYear W27954329142018 @default.
• W2795432914 countsByYear W27954329142019 @default.
• W2795432914 countsByYear W27954329142020 @default.
• W2795432914 countsByYear W27954329142021 @default.
• W2795432914 countsByYear W27954329142022 @default.
• W2795432914 countsByYear W27954329142023 @default.
• W2795432914 crossrefType "journal-article" @default.
• W2795432914 hasAuthorship W2795432914A5028480925 @default.
• W2795432914 hasAuthorship W2795432914A5064925595 @default.
• W2795432914 hasAuthorship W2795432914A5078788252 @default.
• W2795432914 hasAuthorship W2795432914A5091719257 @default.
• W2795432914 hasBestOaLocation W27954329141 @default.
• W2795432914 hasConcept C12554922 @default.
• W2795432914 hasConcept C1491633281 @default.
• W2795432914 hasConcept C171250308 @default.
• W2795432914 hasConcept C176999471 @default.
• W2795432914 hasConcept C185592680 @default.
• W2795432914 hasConcept C189014844 @default.
• W2795432914 hasConcept C192562407 @default.
• W2795432914 hasConcept C202751555 @default.
• W2795432914 hasConcept C2779227376 @default.
• W2795432914 hasConcept C2779732960 @default.
• W2795432914 hasConcept C2779820397 @default.
• W2795432914 hasConcept C53227056 @default.
• W2795432914 hasConcept C55493867 @default.
• W2795432914 hasConcept C86803240 @default.
• W2795432914 hasConceptScore W2795432914C12554922 @default.
• W2795432914 hasConceptScore W2795432914C1491633281 @default.
• W2795432914 hasConceptScore W2795432914C171250308 @default.
• W2795432914 hasConceptScore W2795432914C176999471 @default.
• W2795432914 hasConceptScore W2795432914C185592680 @default.
• W2795432914 hasConceptScore W2795432914C189014844 @default.
• W2795432914 hasConceptScore W2795432914C192562407 @default.
• W2795432914 hasConceptScore W2795432914C202751555 @default.
• W2795432914 hasConceptScore W2795432914C2779227376 @default.
• W2795432914 hasConceptScore W2795432914C2779732960 @default.
• W2795432914 hasConceptScore W2795432914C2779820397 @default.
• W2795432914 hasConceptScore W2795432914C53227056 @default.
• W2795432914 hasConceptScore W2795432914C55493867 @default.
• W2795432914 hasConceptScore W2795432914C86803240 @default.
• W2795432914 hasLocation W27954329141 @default.
• W2795432914 hasLocation W27954329142 @default.
• W2795432914 hasLocation W27954329143 @default.
• W2795432914 hasLocation W27954329144 @default.
• W2795432914 hasOpenAccess W2795432914 @default.
• W2795432914 hasPrimaryLocation W27954329141 @default.
• W2795432914 hasRelatedWork W2032023073 @default.
• W2795432914 hasRelatedWork W2035961260 @default.
• W2795432914 hasRelatedWork W2073078340 @default.
• W2795432914 hasRelatedWork W2113874846 @default.
• W2795432914 hasRelatedWork W2350749311 @default.
• W2795432914 hasRelatedWork W2359342717 @default.
• W2795432914 hasRelatedWork W2515991595 @default.
• W2795432914 hasRelatedWork W2899084033 @default.

• next