FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795442223> ?p ?o ?g. }

• W2795442223 abstract "Urtica dioica, Taraxacum officinale, Calea integrifolia and Caesalpinia pulcherrima are widely used all over the world for treatment of different illnesses. In Mexico, these plants are traditionally used to alleviate or counteract rheumatism and inflammatory muscle diseases. In the present study we evaluated the activity of aqueous and methanolic extracts of these four plants, on the replication of dengue virus serotype 2 (DENV2). Extraction process was carried out in a Soxtherm® system at 60, 85 and 120 °C; a chemical fractionation in silica gel chromatography was performed and compounds present in the active fractions were identified by HPLC-DAD-ESI/MSn. The cytotoxic concentration and the inhibitory effect of extracts or fractions on the DENV2 replication were analyzed in the BHK-21 cell line (plaque forming assay). The half maximal inhibitory concentration (IC50) and the selectivity index (SI) were calculated for the extracts and fractions. The methanolic extracts at 60 °C of T. officinale and U. dioica showed the higher inhibitory effects on DENV2 replication. After the chemical fractionation, the higher activity fraction was found for U. dioica and T. officinale, presenting IC50 values of 165.7 ± 3.85 and 126.1 ± 2.80 μg/ml, respectively; SI values were 5.59 and 6.01 for each fraction. The compounds present in T. officinale, were luteolin and caffeoylquinic acids derivatives and quercertin diclycosides. The compounds in the active fraction of U. dioica, were, chlorogenic acid, quercertin derivatives and flavonol glycosides (quercetin and kaempferol). Two fractions from U. dioica and T. officinale methanolic extracts with anti-dengue activity were found. The compounds present in both fractions were identified, several recognized molecules have demonstrated activity against other viral species. Subsequent biological analysis of the molecules, alone or in combination, contained in the extracts will be carried out to develop therapeutics against DENV2." @default.
• W2795442223 created "2018-04-13" @default.
• W2795442223 creator A5004602159 @default.
• W2795442223 creator A5006081900 @default.
• W2795442223 creator A5020174715 @default.
• W2795442223 creator A5038951415 @default.
• W2795442223 creator A5065744630 @default.
• W2795442223 creator A5066251849 @default.
• W2795442223 creator A5087493659 @default.
• W2795442223 date "2018-03-16" @default.
• W2795442223 modified "2023-10-17" @default.
• W2795442223 title "Taraxacum officinale and Urtica dioica extracts inhibit dengue virus serotype 2 replication in vitro" @default.
• W2795442223 cites W1488276516 @default.
• W2795442223 cites W1773048998 @default.
• W2795442223 cites W1976003343 @default.
• W2795442223 cites W1978410163 @default.
• W2795442223 cites W1980609495 @default.
• W2795442223 cites W1981333644 @default.
• W2795442223 cites W1992538565 @default.
• W2795442223 cites W2003896599 @default.
• W2795442223 cites W2009948125 @default.
• W2795442223 cites W2010264548 @default.
• W2795442223 cites W2010490509 @default.
• W2795442223 cites W2012832934 @default.
• W2795442223 cites W2021418062 @default.
• W2795442223 cites W2024109825 @default.
• W2795442223 cites W2031102828 @default.
• W2795442223 cites W2037309649 @default.
• W2795442223 cites W2042170514 @default.
• W2795442223 cites W2042479028 @default.
• W2795442223 cites W2048120664 @default.
• W2795442223 cites W2068539496 @default.
• W2795442223 cites W2069528778 @default.
• W2795442223 cites W2069978879 @default.
• W2795442223 cites W2073727854 @default.
• W2795442223 cites W2087541526 @default.
• W2795442223 cites W2089906454 @default.
• W2795442223 cites W2092342449 @default.
• W2795442223 cites W2095438561 @default.
• W2795442223 cites W2096816967 @default.
• W2795442223 cites W2114918609 @default.
• W2795442223 cites W2117613022 @default.
• W2795442223 cites W2121522081 @default.
• W2795442223 cites W2126789944 @default.
• W2795442223 cites W2131222241 @default.
• W2795442223 cites W2134867584 @default.
• W2795442223 cites W2138033073 @default.
• W2795442223 cites W2138061944 @default.
• W2795442223 cites W2140034264 @default.
• W2795442223 cites W2149277978 @default.
• W2795442223 cites W2154650052 @default.
• W2795442223 cites W2159415883 @default.
• W2795442223 cites W2170730603 @default.
• W2795442223 cites W2215640744 @default.
• W2795442223 cites W2217035813 @default.
• W2795442223 cites W2255517349 @default.
• W2795442223 cites W2313133847 @default.
• W2795442223 cites W2323091040 @default.
• W2795442223 cites W2326931786 @default.
• W2795442223 cites W2430269436 @default.
• W2795442223 cites W2483340107 @default.
• W2795442223 cites W2515263026 @default.
• W2795442223 cites W2604849278 @default.
• W2795442223 cites W2607130912 @default.
• W2795442223 cites W263192705 @default.
• W2795442223 doi "https://doi.org/10.1186/s12906-018-2163-3" @default.
• W2795442223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5857124" @default.
• W2795442223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29548293" @default.
• W2795442223 hasPublicationYear "2018" @default.
• W2795442223 type Work @default.
• W2795442223 sameAs 2795442223 @default.
• W2795442223 citedByCount "26" @default.
• W2795442223 countsByYear W27954422232019 @default.
• W2795442223 countsByYear W27954422232020 @default.
• W2795442223 countsByYear W27954422232021 @default.
• W2795442223 countsByYear W27954422232022 @default.
• W2795442223 countsByYear W27954422232023 @default.
• W2795442223 crossrefType "journal-article" @default.
• W2795442223 hasAuthorship W2795442223A5004602159 @default.
• W2795442223 hasAuthorship W2795442223A5006081900 @default.
• W2795442223 hasAuthorship W2795442223A5020174715 @default.
• W2795442223 hasAuthorship W2795442223A5038951415 @default.
• W2795442223 hasAuthorship W2795442223A5065744630 @default.
• W2795442223 hasAuthorship W2795442223A5066251849 @default.
• W2795442223 hasAuthorship W2795442223A5087493659 @default.
• W2795442223 hasBestOaLocation W27954422231 @default.
• W2795442223 hasConcept C142724271 @default.
• W2795442223 hasConcept C185592680 @default.
• W2795442223 hasConcept C188947578 @default.
• W2795442223 hasConcept C204787440 @default.
• W2795442223 hasConcept C2776500997 @default.
• W2795442223 hasConcept C2777810353 @default.
• W2795442223 hasConcept C2778004101 @default.
• W2795442223 hasConcept C2778804639 @default.
• W2795442223 hasConcept C2779964429 @default.
• W2795442223 hasConcept C2780117898 @default.
• W2795442223 hasConcept C2781263971 @default.
• W2795442223 hasConcept C2781264555 @default.
• W2795442223 hasConcept C2909010401 @default.
• W2795442223 hasConcept C43617362 @default.

• next