FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795452451> ?p ?o ?g. }

• W2795452451 endingPage "2898" @default.
• W2795452451 startingPage "2891" @default.
• W2795452451 abstract "Abstract Since a report of some 50 years ago describing refractory anemia associated with group C monosomy, monosomy 7 (−7) and interstitial deletions of chromosome 7 (del(7q)) have been established as one of the most frequent chromosomal aberrations found in essentially all types of myeloid tumors regardless of patient age and disease etiology. In the last century, researchers sought recessive myeloid tumor-suppressor genes by attempting to determine commonly deleted regions (CDRs) in del(7q) patients. However, these efforts were not successful. Today, tumor suppressors located in 7q are believed to act in a haploinsufficient fashion, and powerful new technologies such as microarray comparative genomic hybridization and high-throughput sequencing allow comprehensive searches throughout the genes encoded on 7q. Among those proposed as promising candidates, 4 have been validated by gene targeting in mouse models. SAMD9 (sterile α motif domain 9) and SAMD9L (SAMD9-like) encode related endosomal proteins, mutations of which cause hereditary diseases with strong propensity to infantile myelodysplastic syndrome (MDS) harboring monosomy 7. Because MDS develops in SAMD9L-deficient mice over their lifetime, SAMD9/SAMD9L are likely responsible for sporadic MDS with −7/del(7q) as the sole anomaly. EZH2 (enhancer of zeste homolog 2) and MLL3 (mixed lineage leukemia 3) encode histone-modifying enzymes; loss-of-function mutations of these are detected in some myeloid tumors at high frequencies. In contrast to SAMD9/SAMD9L, loss of EZH2 or MLL3 likely contributes to myeloid tumorigenesis in cooperation with additional specific gene alterations such as of TET2 or genes involved in the p53/Ras pathway, respectively. Distinctive roles with different significance of the loss of multiple responsible genes render the complex nature of myeloid tumors carrying −7/del(7q)." @default.
• W2795452451 created "2018-04-13" @default.
• W2795452451 creator A5018769284 @default.
• W2795452451 creator A5062110934 @default.
• W2795452451 creator A5091300315 @default.
• W2795452451 date "2018-06-28" @default.
• W2795452451 modified "2023-10-14" @default.
• W2795452451 title "The enigma of monosomy 7" @default.
• W2795452451 cites W1514779475 @default.
• W2795452451 cites W1528147088 @default.
• W2795452451 cites W1538892167 @default.
• W2795452451 cites W1644850431 @default.
• W2795452451 cites W1959248044 @default.
• W2795452451 cites W1963736125 @default.
• W2795452451 cites W1966530560 @default.
• W2795452451 cites W1970309962 @default.
• W2795452451 cites W1970360675 @default.
• W2795452451 cites W1970972261 @default.
• W2795452451 cites W1973279069 @default.
• W2795452451 cites W1979882109 @default.
• W2795452451 cites W1987523347 @default.
• W2795452451 cites W1989506625 @default.
• W2795452451 cites W1992275707 @default.
• W2795452451 cites W1994547058 @default.
• W2795452451 cites W1995388872 @default.
• W2795452451 cites W1999364945 @default.
• W2795452451 cites W2004730826 @default.
• W2795452451 cites W2005405628 @default.
• W2795452451 cites W2015132841 @default.
• W2795452451 cites W2015844263 @default.
• W2795452451 cites W2016644845 @default.
• W2795452451 cites W2017337160 @default.
• W2795452451 cites W2017822270 @default.
• W2795452451 cites W2020008959 @default.
• W2795452451 cites W2022026311 @default.
• W2795452451 cites W2023416993 @default.
• W2795452451 cites W2024604338 @default.
• W2795452451 cites W2026769136 @default.
• W2795452451 cites W2027877663 @default.
• W2795452451 cites W2033514598 @default.
• W2795452451 cites W2037330840 @default.
• W2795452451 cites W2037371685 @default.
• W2795452451 cites W2037546451 @default.
• W2795452451 cites W2043201993 @default.
• W2795452451 cites W2046766666 @default.
• W2795452451 cites W2047791752 @default.
• W2795452451 cites W2049532768 @default.
• W2795452451 cites W2055519810 @default.
• W2795452451 cites W2055754023 @default.
• W2795452451 cites W2057224174 @default.
• W2795452451 cites W2060608189 @default.
• W2795452451 cites W2064754490 @default.
• W2795452451 cites W2070152906 @default.
• W2795452451 cites W2071092346 @default.
• W2795452451 cites W2072296994 @default.
• W2795452451 cites W2074191990 @default.
• W2795452451 cites W2075087486 @default.
• W2795452451 cites W2076257222 @default.
• W2795452451 cites W2077350346 @default.
• W2795452451 cites W2078729110 @default.
• W2795452451 cites W2080533950 @default.
• W2795452451 cites W2080699730 @default.
• W2795452451 cites W2084225851 @default.
• W2795452451 cites W2085311018 @default.
• W2795452451 cites W2093601292 @default.
• W2795452451 cites W2094169805 @default.
• W2795452451 cites W2105882251 @default.
• W2795452451 cites W2106078499 @default.
• W2795452451 cites W2106194243 @default.
• W2795452451 cites W2113165796 @default.
• W2795452451 cites W2115707319 @default.
• W2795452451 cites W2125597344 @default.
• W2795452451 cites W2130000464 @default.
• W2795452451 cites W2134002822 @default.
• W2795452451 cites W2140196635 @default.
• W2795452451 cites W2147370638 @default.
• W2795452451 cites W2149685951 @default.
• W2795452451 cites W2154284135 @default.
• W2795452451 cites W2154787712 @default.
• W2795452451 cites W2159249303 @default.
• W2795452451 cites W2233236546 @default.
• W2795452451 cites W228303033 @default.
• W2795452451 cites W2326726820 @default.
• W2795452451 cites W2399654760 @default.
• W2795452451 cites W2410168491 @default.
• W2795452451 cites W2553468399 @default.
• W2795452451 cites W2577904069 @default.
• W2795452451 cites W2588137098 @default.
• W2795452451 cites W2599756044 @default.
• W2795452451 cites W2622882222 @default.
• W2795452451 cites W2749642104 @default.
• W2795452451 cites W2749939850 @default.
• W2795452451 cites W2760824708 @default.
• W2795452451 cites W2767347576 @default.
• W2795452451 cites W2768995679 @default.
• W2795452451 cites W2773365524 @default.
• W2795452451 cites W3026521677 @default.
• W2795452451 cites W4246479620 @default.

• next