FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795522686> ?p ?o ?g. }

• W2795522686 endingPage "9" @default.
• W2795522686 startingPage "1" @default.
• W2795522686 abstract "Epigenetic modifications are involved in global reprogramming of the cell transcriptome. Therefore, synchronized major shifts in the expression of many genes could be achieved through epigenetic changes. The regulation of gene expression could be implemented by different epigenetic events including histone modifications, DNA methylation and chromatin remodelling. Interestingly, it has been documented that reprogramming of somatic cells to induced pluripotent stem (iPS) cells is also a typical example of epigenetic modifications. Additionally, epigenetic would determine the fates of almost all cells upon differentiation of stem cells into somatic cells. Currently, generation of iPS cells through epigenetic modifications is a routine laboratory practice. Despite all our knowledge, inconsistency in the results of reprogramming and differentiation of stem cells, highlight the need for more thorough investigation into the role of epigenetic modification in generation and maintenance of stem cells. Besides, subtle differences have been observed among different iPS cells and between iPS and ES cells. Although, a handful of detailed review regarding the status of epigenetics in stem cells has been published previously, in the current review, an abstracted and rather simplified view has been presented for those who want to gain a more general overview on this subject. However, almost all key references and ground breaking studies were included, which could be further explored to gain more in depth knowledge regarding this topic. The most dominant epigenetic changes have been presented followed by the impacts of such changes on the global gene expression. Epigenetic status in iPS and ES cells were compared. In addition to including the issues related to X-chromosome reactivation in the stem cells, we have also included loss of imprinting for some genes as a major drawback in generation of iPS cells. Finally, the overall impacts of epigenetic modifications on different aspects of stem cells has been discussed, including their use in cell therapy." @default.
• W2795522686 created "2018-04-13" @default.
• W2795522686 creator A5012898980 @default.
• W2795522686 creator A5030284071 @default.
• W2795522686 creator A5057236272 @default.
• W2795522686 date "2018-09-01" @default.
• W2795522686 modified "2023-10-03" @default.
• W2795522686 title "Epigenetic modifications in the embryonic and induced pluripotent stem cells" @default.
• W2795522686 cites W1171540079 @default.
• W2795522686 cites W1532925054 @default.
• W2795522686 cites W1844364098 @default.
• W2795522686 cites W1855267957 @default.
• W2795522686 cites W1868142707 @default.
• W2795522686 cites W1964298436 @default.
• W2795522686 cites W1964499071 @default.
• W2795522686 cites W1972334415 @default.
• W2795522686 cites W1974450480 @default.
• W2795522686 cites W1975265345 @default.
• W2795522686 cites W1979963706 @default.
• W2795522686 cites W1986586739 @default.
• W2795522686 cites W1987774343 @default.
• W2795522686 cites W1991786443 @default.
• W2795522686 cites W1991857137 @default.
• W2795522686 cites W1993165112 @default.
• W2795522686 cites W1994029368 @default.
• W2795522686 cites W1994115491 @default.
• W2795522686 cites W1996076770 @default.
• W2795522686 cites W2001284661 @default.
• W2795522686 cites W2002702165 @default.
• W2795522686 cites W2005725366 @default.
• W2795522686 cites W2006033351 @default.
• W2795522686 cites W2009858080 @default.
• W2795522686 cites W2010031978 @default.
• W2795522686 cites W2011391252 @default.
• W2795522686 cites W2011591794 @default.
• W2795522686 cites W2011793799 @default.
• W2795522686 cites W2013346353 @default.
• W2795522686 cites W2017398815 @default.
• W2795522686 cites W2020298913 @default.
• W2795522686 cites W2022818353 @default.
• W2795522686 cites W2023563083 @default.
• W2795522686 cites W2024839991 @default.
• W2795522686 cites W2028907427 @default.
• W2795522686 cites W2031496441 @default.
• W2795522686 cites W2035906834 @default.
• W2795522686 cites W2038320708 @default.
• W2795522686 cites W2039551265 @default.
• W2795522686 cites W2045960652 @default.
• W2795522686 cites W2046357669 @default.
• W2795522686 cites W2046691617 @default.
• W2795522686 cites W2047418655 @default.
• W2795522686 cites W2051181798 @default.
• W2795522686 cites W2051656825 @default.
• W2795522686 cites W2053860318 @default.
• W2795522686 cites W2053911973 @default.
• W2795522686 cites W2055327776 @default.
• W2795522686 cites W2056403943 @default.
• W2795522686 cites W2056694786 @default.
• W2795522686 cites W2068157186 @default.
• W2795522686 cites W2068751516 @default.
• W2795522686 cites W2070416230 @default.
• W2795522686 cites W2072638557 @default.
• W2795522686 cites W2078735069 @default.
• W2795522686 cites W2079695054 @default.
• W2795522686 cites W2081204899 @default.
• W2795522686 cites W2082599074 @default.
• W2795522686 cites W2083577502 @default.
• W2795522686 cites W2086524378 @default.
• W2795522686 cites W2091658754 @default.
• W2795522686 cites W2091835858 @default.
• W2795522686 cites W2095718399 @default.
• W2795522686 cites W2097342705 @default.
• W2795522686 cites W2099067892 @default.
• W2795522686 cites W2099689431 @default.
• W2795522686 cites W2108370794 @default.
• W2795522686 cites W2114094997 @default.
• W2795522686 cites W2114970231 @default.
• W2795522686 cites W2115709759 @default.
• W2795522686 cites W2117792884 @default.
• W2795522686 cites W2118627077 @default.
• W2795522686 cites W2118937292 @default.
• W2795522686 cites W2123400162 @default.
• W2795522686 cites W2123773614 @default.
• W2795522686 cites W2124359985 @default.
• W2795522686 cites W2125987139 @default.
• W2795522686 cites W2127286180 @default.
• W2795522686 cites W2127746941 @default.
• W2795522686 cites W2138848739 @default.
• W2795522686 cites W2139610636 @default.
• W2795522686 cites W2142046859 @default.
• W2795522686 cites W2147524392 @default.
• W2795522686 cites W2147541527 @default.
• W2795522686 cites W2151591434 @default.
• W2795522686 cites W2159207633 @default.
• W2795522686 cites W2159504778 @default.
• W2795522686 cites W2165556149 @default.
• W2795522686 cites W2166599552 @default.
• W2795522686 cites W2171985490 @default.

• next