Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795535550> ?p ?o ?g. }
- W2795535550 endingPage "658.e4" @default.
- W2795535550 startingPage "649" @default.
- W2795535550 abstract "Toll-like receptor 9 (TLR9) recognizes DNA containing CpG motifs derived from bacteria and viruses and activates the innate immune response to eliminate them. TLR9 is known to bind to CpG DNA, and here, we identified another DNA binding site in TLR9 that binds DNA containing cytosine at the second position from the 5′ end (5′-xCx DNA). 5′-xCx DNAs bound to TLR9 in the presence of CpG DNA and cooperatively promoted dimerization and activation of TLR9. Binding at both sites was important for efficient activation of TLR9. The 5′-xCx DNA bound the site corresponding to the nucleoside binding site in TLR7 and TLR8 as revealed by the structural analysis. This study revealed that TLR9 recognizes two types of DNA through its two binding sites for efficient activation. This information may contribute to the development of drugs that control the activity of TLR9." @default.
- W2795535550 created "2018-04-13" @default.
- W2795535550 creator A5014507741 @default.
- W2795535550 creator A5034277203 @default.
- W2795535550 creator A5045382494 @default.
- W2795535550 creator A5056464997 @default.
- W2795535550 creator A5080600650 @default.
- W2795535550 creator A5089115794 @default.
- W2795535550 date "2018-04-01" @default.
- W2795535550 modified "2023-10-14" @default.
- W2795535550 title "Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation" @default.
- W2795535550 cites W1514540900 @default.
- W2795535550 cites W1539796472 @default.
- W2795535550 cites W1742351369 @default.
- W2795535550 cites W1969072247 @default.
- W2795535550 cites W1973659410 @default.
- W2795535550 cites W1988299037 @default.
- W2795535550 cites W1994391392 @default.
- W2795535550 cites W1995586746 @default.
- W2795535550 cites W2025633900 @default.
- W2795535550 cites W2032639905 @default.
- W2795535550 cites W2038840577 @default.
- W2795535550 cites W2042433863 @default.
- W2795535550 cites W2048067575 @default.
- W2795535550 cites W2062267695 @default.
- W2795535550 cites W2065276143 @default.
- W2795535550 cites W2076361525 @default.
- W2795535550 cites W2080399344 @default.
- W2795535550 cites W2087661745 @default.
- W2795535550 cites W2090877072 @default.
- W2795535550 cites W2100019645 @default.
- W2795535550 cites W2111260918 @default.
- W2795535550 cites W2117200779 @default.
- W2795535550 cites W2124651203 @default.
- W2795535550 cites W2125491088 @default.
- W2795535550 cites W2129961630 @default.
- W2795535550 cites W2144081223 @default.
- W2795535550 cites W2144652247 @default.
- W2795535550 cites W2146080841 @default.
- W2795535550 cites W2147763501 @default.
- W2795535550 cites W2154714625 @default.
- W2795535550 cites W2161208630 @default.
- W2795535550 cites W2340906209 @default.
- W2795535550 cites W2462036242 @default.
- W2795535550 cites W2465415317 @default.
- W2795535550 cites W2530273804 @default.
- W2795535550 cites W2579951821 @default.
- W2795535550 cites W2583676372 @default.
- W2795535550 cites W2619402039 @default.
- W2795535550 cites W4248872320 @default.
- W2795535550 doi "https://doi.org/10.1016/j.immuni.2018.03.013" @default.
- W2795535550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29625894" @default.
- W2795535550 hasPublicationYear "2018" @default.
- W2795535550 type Work @default.
- W2795535550 sameAs 2795535550 @default.
- W2795535550 citedByCount "88" @default.
- W2795535550 countsByYear W27955355502018 @default.
- W2795535550 countsByYear W27955355502019 @default.
- W2795535550 countsByYear W27955355502020 @default.
- W2795535550 countsByYear W27955355502021 @default.
- W2795535550 countsByYear W27955355502022 @default.
- W2795535550 countsByYear W27955355502023 @default.
- W2795535550 crossrefType "journal-article" @default.
- W2795535550 hasAuthorship W2795535550A5014507741 @default.
- W2795535550 hasAuthorship W2795535550A5034277203 @default.
- W2795535550 hasAuthorship W2795535550A5045382494 @default.
- W2795535550 hasAuthorship W2795535550A5056464997 @default.
- W2795535550 hasAuthorship W2795535550A5080600650 @default.
- W2795535550 hasAuthorship W2795535550A5089115794 @default.
- W2795535550 hasBestOaLocation W27955355501 @default.
- W2795535550 hasConcept C101762097 @default.
- W2795535550 hasConcept C104317684 @default.
- W2795535550 hasConcept C107824862 @default.
- W2795535550 hasConcept C136449434 @default.
- W2795535550 hasConcept C140173407 @default.
- W2795535550 hasConcept C150194340 @default.
- W2795535550 hasConcept C153911025 @default.
- W2795535550 hasConcept C170493617 @default.
- W2795535550 hasConcept C190727270 @default.
- W2795535550 hasConcept C2776709828 @default.
- W2795535550 hasConcept C2779138994 @default.
- W2795535550 hasConcept C2779836521 @default.
- W2795535550 hasConcept C2908999202 @default.
- W2795535550 hasConcept C3662595 @default.
- W2795535550 hasConcept C552990157 @default.
- W2795535550 hasConcept C55493867 @default.
- W2795535550 hasConcept C86803240 @default.
- W2795535550 hasConcept C95444343 @default.
- W2795535550 hasConceptScore W2795535550C101762097 @default.
- W2795535550 hasConceptScore W2795535550C104317684 @default.
- W2795535550 hasConceptScore W2795535550C107824862 @default.
- W2795535550 hasConceptScore W2795535550C136449434 @default.
- W2795535550 hasConceptScore W2795535550C140173407 @default.
- W2795535550 hasConceptScore W2795535550C150194340 @default.
- W2795535550 hasConceptScore W2795535550C153911025 @default.
- W2795535550 hasConceptScore W2795535550C170493617 @default.
- W2795535550 hasConceptScore W2795535550C190727270 @default.
- W2795535550 hasConceptScore W2795535550C2776709828 @default.