FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795536319> ?p ?o ?g. }

• W2795536319 abstract "Hepatocellular carcinoma (HCC) is one of the most common malignancies and causes of death worldwide. Research investigating novel therapeutic strategies for the treatment of HCC is urgently required. Monoclonal antibodies (mAbs) that target the programmed cell death‑1 (PD‑1/PDCD1)/programmed death-ligand 1 (PD-L1) immune checkpoint have demonstrated substantial clinical benefit for a variety of solid tumors; however, these mAbs have not been well studied in HCC. In the present study, Sp2/0-Ag14 myeloma cells and spleen cells derived from BALB/c mice immunized with the recombinant human PD‑1/PDCD1 protein were fused for the production of novel antibodies. The 9E11 mAb, which exhibited the highest specificity for PD‑1 in HCC tissues in western blot and immunohistochemical staining analyses, was used to investigate the clinical significance of PD‑1 expression in HCC tissues from 77 cases, which were collected and examined histologically. Overexpression of PD‑1 was identified in peritumoral tissues, primarily in the liver portal region. Importantly, by analyzing the clinical data from 77 HCC patients, the expression of PD‑1 was observed to be significantly correlated with larger tumor size (>5 cm) and poorly differentiated tumors. In addition, PD‑1 expression was moderately correlated with venous thrombosis, but not correlated with patient sex or age, liver cirrhosis, hepatitis B, tumor, node and metastasis (TNM) stage or tumor location. The results of the present study suggest that high-level PD‑1 expression may be an important factor associated with the immune checkpoint pathway in HCC. The results suggest that PD‑1 serves an important role in tumor immune evasion and may be a valuable immunodiagnostic marker. In addition, PD‑1 may serve as a therapeutic target for patients presenting with poorly differentiated HCC, thus indicating the potential application of a PD‑1 inhibitor for the treatment of HCC patients." @default.
• W2795536319 created "2018-04-13" @default.
• W2795536319 creator A5030872551 @default.
• W2795536319 creator A5038111671 @default.
• W2795536319 creator A5039049676 @default.
• W2795536319 creator A5051526091 @default.
• W2795536319 creator A5063958787 @default.
• W2795536319 creator A5066518862 @default.
• W2795536319 creator A5081025967 @default.
• W2795536319 creator A5081197970 @default.
• W2795536319 creator A5083824317 @default.
• W2795536319 date "2018-04-04" @default.
• W2795536319 modified "2023-09-27" @default.
• W2795536319 title "Expression and clinical significance of PD‑1 in hepatocellular carcinoma tissues detected by a novel mouse anti-human PD‑1 monoclonal antibody" @default.
• W2795536319 cites W115125409 @default.
• W2795536319 cites W1967827870 @default.
• W2795536319 cites W1971208896 @default.
• W2795536319 cites W1990675339 @default.
• W2795536319 cites W1991301773 @default.
• W2795536319 cites W2000694500 @default.
• W2795536319 cites W2016789384 @default.
• W2795536319 cites W2016983859 @default.
• W2795536319 cites W2018289835 @default.
• W2795536319 cites W2022580424 @default.
• W2795536319 cites W2030637448 @default.
• W2795536319 cites W2034836077 @default.
• W2795536319 cites W2035012596 @default.
• W2795536319 cites W2035660473 @default.
• W2795536319 cites W2036146147 @default.
• W2795536319 cites W2042108941 @default.
• W2795536319 cites W2043579427 @default.
• W2795536319 cites W2053353274 @default.
• W2795536319 cites W2073382063 @default.
• W2795536319 cites W2100837269 @default.
• W2795536319 cites W2101653483 @default.
• W2795536319 cites W2107564997 @default.
• W2795536319 cites W2108933323 @default.
• W2795536319 cites W2112601576 @default.
• W2795536319 cites W2112927491 @default.
• W2795536319 cites W2115525561 @default.
• W2795536319 cites W2118982164 @default.
• W2795536319 cites W2122495232 @default.
• W2795536319 cites W2123176392 @default.
• W2795536319 cites W2126216210 @default.
• W2795536319 cites W2129806226 @default.
• W2795536319 cites W2131577873 @default.
• W2795536319 cites W2131950300 @default.
• W2795536319 cites W2136859769 @default.
• W2795536319 cites W2137778587 @default.
• W2795536319 cites W2138590389 @default.
• W2795536319 cites W2139591061 @default.
• W2795536319 cites W2141360391 @default.
• W2795536319 cites W2155464214 @default.
• W2795536319 cites W2163401417 @default.
• W2795536319 cites W2179917398 @default.
• W2795536319 cites W2187430385 @default.
• W2795536319 cites W2223743646 @default.
• W2795536319 cites W2271055005 @default.
• W2795536319 cites W2316831371 @default.
• W2795536319 cites W2414977199 @default.
• W2795536319 cites W2525717489 @default.
• W2795536319 cites W2560367415 @default.
• W2795536319 cites W2572174216 @default.
• W2795536319 cites W2613589727 @default.
• W2795536319 cites W995625926 @default.
• W2795536319 doi "https://doi.org/10.3892/ijo.2018.4358" @default.
• W2795536319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6929674" @default.
• W2795536319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29620156" @default.
• W2795536319 hasPublicationYear "2018" @default.
• W2795536319 type Work @default.
• W2795536319 sameAs 2795536319 @default.
• W2795536319 citedByCount "9" @default.
• W2795536319 countsByYear W27955363192019 @default.
• W2795536319 countsByYear W27955363192020 @default.
• W2795536319 countsByYear W27955363192021 @default.
• W2795536319 countsByYear W27955363192022 @default.
• W2795536319 countsByYear W27955363192023 @default.
• W2795536319 crossrefType "journal-article" @default.
• W2795536319 hasAuthorship W2795536319A5030872551 @default.
• W2795536319 hasAuthorship W2795536319A5038111671 @default.
• W2795536319 hasAuthorship W2795536319A5039049676 @default.
• W2795536319 hasAuthorship W2795536319A5051526091 @default.
• W2795536319 hasAuthorship W2795536319A5063958787 @default.
• W2795536319 hasAuthorship W2795536319A5066518862 @default.
• W2795536319 hasAuthorship W2795536319A5081025967 @default.
• W2795536319 hasAuthorship W2795536319A5081197970 @default.
• W2795536319 hasAuthorship W2795536319A5083824317 @default.
• W2795536319 hasBestOaLocation W27955363191 @default.
• W2795536319 hasConcept C121608353 @default.
• W2795536319 hasConcept C126322002 @default.
• W2795536319 hasConcept C142724271 @default.
• W2795536319 hasConcept C159654299 @default.
• W2795536319 hasConcept C203014093 @default.
• W2795536319 hasConcept C204232928 @default.
• W2795536319 hasConcept C2777214474 @default.
• W2795536319 hasConcept C2777658100 @default.
• W2795536319 hasConcept C2777701055 @default.
• W2795536319 hasConcept C2778019345 @default.
• W2795536319 hasConcept C2779013556 @default.
• W2795536319 hasConcept C2780931953 @default.

• next