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- W2795581362 abstract "Abstract 2,6‐Diaminopurine and guanine 2′‐deoxynucleosides substituted with a fluoromethyl, methyl, vinyl, ethyl, or azido group at the C ‐4’ position of the sugar moiety 1–10 were synthesized and their activity against HIV and HBV were determined. 4′‐Fluoromethyl and 4′‐methyl derivatives 1 and 2 , respectively, were synthesized by glycosidation of the 4′‐substituted sugars 11 and 12 , respectively, using 2,6‐diaminopurine, followed by deoxygenation of the 2′‐hydroxyl group. 4′‐Vinyl analog 3 was synthesized from 4′‐hydroxymethylnucleoside 19 , and 4′‐ethyl derivative 4 was obtained by hydrogenation of 3 . 4′‐Azide analog 5 was synthesized by S N Ar reaction of guanine derivative 23 with ammonia. Nucleosides 1–5 were converted to the corresponding guanine derivatives 6–10 using adenosine deaminase. Some of these compounds exhibited substantial to potent anti‐HIV and HBV activity with generally favorable cytotoxicity profiles." @default.
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- W2795581362 date "2018-03-22" @default.
- W2795581362 modified "2023-09-27" @default.
- W2795581362 title "Synthesis of 4′-Substituted Purine 2′-Deoxynucleosides and Their Activity against Human Immunodeficiency Virus Type 1 and Hepatitis B Virus" @default.
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- W2795581362 doi "https://doi.org/10.1002/slct.201800527" @default.
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