FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795633066> ?p ?o ?g. }

• W2795633066 endingPage "1331" @default.
• W2795633066 startingPage "1322" @default.
• W2795633066 abstract "Previously, we showed that thyroid hormone (TH) triiodothyronine (T3) enhanced β-cell functional maturation through induction of Mafa. High levels of T3 have been linked to decreased life span in mammals and low levels to lengthened life span, suggesting a relationship between TH and aging. Here, we show that T3 increased p16Ink4a (a β-cell senescence marker and effector) mRNA in rodent and human β-cells. The kinetics of Mafa and p16Ink4a induction suggested both genes as targets of TH via TH receptors (THRs) binding to specific response elements. Using specific agonists CO23 and GC1, we showed that p16Ink4a expression was controlled by THRA and Mafa by THRB. Using chromatin immunoprecipitation and a transient transfection yielding biotinylated THRB1 or THRA isoforms to achieve specificity, we determined that THRA isoform bound to p16Ink4a, whereas THRB1 bound to Mafa but not to p16Ink4a. On a cellular level, T3 treatment accelerated cell senescence as shown by increased number of β-cells with acidic β-galactosidase activity. Our data show that T3 can simultaneously induce both maturation (Mafa) and aging (p16Ink4a) effectors and that these dichotomous effects are mediated through different THR isoforms. These findings may be important for further improving stem cell differentiation protocols to produce functional β-cells for replacement therapies in diabetes." @default.
• W2795633066 created "2018-04-13" @default.
• W2795633066 creator A5006444990 @default.
• W2795633066 creator A5007657618 @default.
• W2795633066 creator A5008915190 @default.
• W2795633066 creator A5017706607 @default.
• W2795633066 creator A5025382989 @default.
• W2795633066 creator A5033831558 @default.
• W2795633066 creator A5040787757 @default.
• W2795633066 creator A5051004100 @default.
• W2795633066 creator A5057741725 @default.
• W2795633066 creator A5058240948 @default.
• W2795633066 creator A5070508954 @default.
• W2795633066 creator A5083159070 @default.
• W2795633066 creator A5083756597 @default.
• W2795633066 date "2018-04-06" @default.
• W2795633066 modified "2023-10-10" @default.
• W2795633066 title "T3 Induces Both Markers of Maturation and Aging in Pancreatic β-Cells" @default.
• W2795633066 cites W1542474163 @default.
• W2795633066 cites W1963650290 @default.
• W2795633066 cites W1966952344 @default.
• W2795633066 cites W1971821112 @default.
• W2795633066 cites W2011766042 @default.
• W2795633066 cites W2023549924 @default.
• W2795633066 cites W2023552937 @default.
• W2795633066 cites W2028690161 @default.
• W2795633066 cites W2032472678 @default.
• W2795633066 cites W2034019777 @default.
• W2795633066 cites W2034804666 @default.
• W2795633066 cites W2041036994 @default.
• W2795633066 cites W2054361177 @default.
• W2795633066 cites W2054777152 @default.
• W2795633066 cites W2060478264 @default.
• W2795633066 cites W2073429636 @default.
• W2795633066 cites W2074341121 @default.
• W2795633066 cites W2077116358 @default.
• W2795633066 cites W2079698011 @default.
• W2795633066 cites W2093680564 @default.
• W2795633066 cites W2106219965 @default.
• W2795633066 cites W2121751945 @default.
• W2795633066 cites W2131585813 @default.
• W2795633066 cites W2139943786 @default.
• W2795633066 cites W2141574143 @default.
• W2795633066 cites W2145679370 @default.
• W2795633066 cites W2148890861 @default.
• W2795633066 cites W2160028030 @default.
• W2795633066 cites W2164751104 @default.
• W2795633066 cites W2168963689 @default.
• W2795633066 cites W2252442238 @default.
• W2795633066 cites W2295694318 @default.
• W2795633066 cites W2436717713 @default.
• W2795633066 cites W2604579271 @default.
• W2795633066 cites W2735590735 @default.
• W2795633066 cites W952995637 @default.
• W2795633066 doi "https://doi.org/10.2337/db18-0030" @default.
• W2795633066 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6014556" @default.
• W2795633066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29625991" @default.
• W2795633066 hasPublicationYear "2018" @default.
• W2795633066 type Work @default.
• W2795633066 sameAs 2795633066 @default.
• W2795633066 citedByCount "14" @default.
• W2795633066 countsByYear W27956330662018 @default.
• W2795633066 countsByYear W27956330662019 @default.
• W2795633066 countsByYear W27956330662020 @default.
• W2795633066 countsByYear W27956330662021 @default.
• W2795633066 countsByYear W27956330662022 @default.
• W2795633066 countsByYear W27956330662023 @default.
• W2795633066 crossrefType "journal-article" @default.
• W2795633066 hasAuthorship W2795633066A5006444990 @default.
• W2795633066 hasAuthorship W2795633066A5007657618 @default.
• W2795633066 hasAuthorship W2795633066A5008915190 @default.
• W2795633066 hasAuthorship W2795633066A5017706607 @default.
• W2795633066 hasAuthorship W2795633066A5025382989 @default.
• W2795633066 hasAuthorship W2795633066A5033831558 @default.
• W2795633066 hasAuthorship W2795633066A5040787757 @default.
• W2795633066 hasAuthorship W2795633066A5051004100 @default.
• W2795633066 hasAuthorship W2795633066A5057741725 @default.
• W2795633066 hasAuthorship W2795633066A5058240948 @default.
• W2795633066 hasAuthorship W2795633066A5070508954 @default.
• W2795633066 hasAuthorship W2795633066A5083159070 @default.
• W2795633066 hasAuthorship W2795633066A5083756597 @default.
• W2795633066 hasBestOaLocation W27956330661 @default.
• W2795633066 hasConcept C101762097 @default.
• W2795633066 hasConcept C104317684 @default.
• W2795633066 hasConcept C134320426 @default.
• W2795633066 hasConcept C1491633281 @default.
• W2795633066 hasConcept C150194340 @default.
• W2795633066 hasConcept C170493617 @default.
• W2795633066 hasConcept C51785407 @default.
• W2795633066 hasConcept C522857546 @default.
• W2795633066 hasConcept C53345823 @default.
• W2795633066 hasConcept C54355233 @default.
• W2795633066 hasConcept C86803240 @default.
• W2795633066 hasConcept C95444343 @default.
• W2795633066 hasConceptScore W2795633066C101762097 @default.
• W2795633066 hasConceptScore W2795633066C104317684 @default.
• W2795633066 hasConceptScore W2795633066C134320426 @default.
• W2795633066 hasConceptScore W2795633066C1491633281 @default.

• next