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• W2795657965 abstract "The goal of our study is to design BaTiO 3 ferroelectric layers that will cover metal implants and provide improved osseointegration. We synthesized ferroelectric BaTiO 3 layers on Pt/fused silica substrates, and we studied their physical and bio-properties. BaTiO 3 and Pt layers were prepared using KrF excimer laser ablation at substrate temperature T s in the range from 200°C to 750°C in vacuum or under oxygen pressure of 10 Pa, 15 Pa, and 20 Pa. The BaTiO 3 /Pt and Pt layers adhered well to the substrates. BaTiO 3 films of crystallite size 60–140 nm were fabricated. Ferroelectric loops were measured and ferroelectricity was also confirmed using Raman scattering measurements. Results of atomic force microscopy topology and the X-ray diffraction structure of the BaTiO 3 /Pt/fused silica multilayers are presented. The adhesion, viability, growth, and osteogenic differentiation of human osteoblast-like Saos-2 cells were also studied. On days 1, 3, and 7 after seeding, the lowest cell numbers were found on non-ferroelectric BaTiO 3 , while the values on ferroelectric BaTiO 3 , on non-annealed and annealed Pt interlayers, and on the control tissue culture polystyrene dishes and microscopic glass slides were similar, and were usually significantly higher than on non-ferroelectric BaTiO 3 . A similar trend was observed for the intensity of the fluorescence of alkaline phosphatase, a medium-term marker of osteogenic differentiation, and of osteocalcin, a late marker of osteogenic differentiation. At the same time, the cell viability, tested on day 1 after seeding, was very high on all tested samples, reaching 93–99%. Ferroelectric BaTiO 3 films deposited on metallic bone implants through a Pt interlayer can therefore markedly improve the osseointegration of these implants in comparison with non-ferroelectric BaTiO 3 films." @default.
• W2795657965 created "2018-04-13" @default.
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• W2795657965 date "2018-04-05" @default.
• W2795657965 modified "2023-10-17" @default.
• W2795657965 title "Laser-synthesized nanocrystalline, ferroelectric, bioactive BaTiO3/Pt/FS for bone implants" @default.
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• W2795657965 doi "https://doi.org/10.1177/0885328218768646" @default.
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