FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795678220> ?p ?o ?g. }

• W2795678220 endingPage "7" @default.
• W2795678220 startingPage "1" @default.
• W2795678220 abstract "Alpha-synuclein ( α -synuclein) and beta-synuclein ( β -synuclein) are presynaptic proteins playing important roles in neuronal plasticity and synaptic vesicle regulation. To evaluate the association of these two proteins and autism spectrum disorder (ASD), we investigated the plasma α -synuclein and β -synuclein levels in 39 male children with ASD (2 subgroups: 25 autism and 14 pervasive developmental disorder-not otherwise specified (PDD-NOS)) comparing with 29 sex- and age-matched controls by using enzyme-linked immunosorbent assay (ELISA). We first determined the levels of these two proteins in the ASD subgroups and found that there were no significant differences in both plasma α -synuclein and β -synuclein levels in the autism and PDD-NOS groups. Thus, we could combine the 2 subgroups into one ASD group. Interestingly, the mean plasma α -synuclein level was significantly lower (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle=italic>0.001</mml:mn></mml:math>) in the ASD children (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mn fontstyle=italic>10.82</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle=italic>6.46</mml:mn></mml:math> ng/mL) than in the controls (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mn fontstyle=italic>29.47</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle=italic>18.62</mml:mn></mml:math> ng/mL), while the mean plasma β -synuclein level in the ASD children (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mn fontstyle=italic>1344.19</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle=italic>160.26</mml:mn></mml:math> ng/mL) was significantly higher (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle=italic>0.05</mml:mn></mml:math>) than in the controls (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mn fontstyle=italic>1219.16</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle=italic>177.10</mml:mn></mml:math> ng/mL). This is the first study examining the associations between α -synuclein and β -synuclein and male ASD patients. We found that alterations in the plasma α -synuclein and β -synuclein levels might be implicated in the association between synaptic abnormalities and ASD pathogenesis." @default.
• W2795678220 created "2018-04-13" @default.
• W2795678220 creator A5052951302 @default.
• W2795678220 creator A5085876733 @default.
• W2795678220 date "2018-01-01" @default.
• W2795678220 modified "2023-10-15" @default.
• W2795678220 title "Significant Changes in Plasma Alpha-Synuclein and Beta-Synuclein Levels in Male Children with Autism Spectrum Disorder" @default.
• W2795678220 cites W1629767210 @default.
• W2795678220 cites W1794697118 @default.
• W2795678220 cites W1860081569 @default.
• W2795678220 cites W1965778124 @default.
• W2795678220 cites W1987693361 @default.
• W2795678220 cites W2010651179 @default.
• W2795678220 cites W2014627341 @default.
• W2795678220 cites W2016898069 @default.
• W2795678220 cites W2016911141 @default.
• W2795678220 cites W2017624408 @default.
• W2795678220 cites W2019942048 @default.
• W2795678220 cites W2025051467 @default.
• W2795678220 cites W2026676471 @default.
• W2795678220 cites W2030772848 @default.
• W2795678220 cites W2038978390 @default.
• W2795678220 cites W2045884403 @default.
• W2795678220 cites W2051126370 @default.
• W2795678220 cites W2060272083 @default.
• W2795678220 cites W2064132534 @default.
• W2795678220 cites W2075906033 @default.
• W2795678220 cites W2082907050 @default.
• W2795678220 cites W2090240161 @default.
• W2795678220 cites W2098229885 @default.
• W2795678220 cites W2108060249 @default.
• W2795678220 cites W2113136223 @default.
• W2795678220 cites W2116597539 @default.
• W2795678220 cites W2119744351 @default.
• W2795678220 cites W2128591660 @default.
• W2795678220 cites W2140709334 @default.
• W2795678220 cites W2147957932 @default.
• W2795678220 cites W2152461870 @default.
• W2795678220 cites W2158197814 @default.
• W2795678220 cites W2159717327 @default.
• W2795678220 cites W2226587564 @default.
• W2795678220 cites W2326870157 @default.
• W2795678220 cites W2401162010 @default.
• W2795678220 cites W2498732400 @default.
• W2795678220 cites W2512757939 @default.
• W2795678220 cites W2577179804 @default.
• W2795678220 cites W2635284473 @default.
• W2795678220 cites W2735677419 @default.
• W2795678220 cites W2755811582 @default.
• W2795678220 cites W4247665917 @default.
• W2795678220 doi "https://doi.org/10.1155/2018/4503871" @default.
• W2795678220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5911343" @default.
• W2795678220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29850516" @default.
• W2795678220 hasPublicationYear "2018" @default.
• W2795678220 type Work @default.
• W2795678220 sameAs 2795678220 @default.
• W2795678220 citedByCount "21" @default.
• W2795678220 countsByYear W27956782202020 @default.
• W2795678220 countsByYear W27956782202021 @default.
• W2795678220 countsByYear W27956782202022 @default.
• W2795678220 countsByYear W27956782202023 @default.
• W2795678220 crossrefType "journal-article" @default.
• W2795678220 hasAuthorship W2795678220A5052951302 @default.
• W2795678220 hasAuthorship W2795678220A5085876733 @default.
• W2795678220 hasBestOaLocation W27956782201 @default.
• W2795678220 hasConcept C11413529 @default.
• W2795678220 hasConcept C118552586 @default.
• W2795678220 hasConcept C205778803 @default.
• W2795678220 hasConcept C2778538070 @default.
• W2795678220 hasConcept C41008148 @default.
• W2795678220 hasConcept C71924100 @default.
• W2795678220 hasConceptScore W2795678220C11413529 @default.
• W2795678220 hasConceptScore W2795678220C118552586 @default.
• W2795678220 hasConceptScore W2795678220C205778803 @default.
• W2795678220 hasConceptScore W2795678220C2778538070 @default.
• W2795678220 hasConceptScore W2795678220C41008148 @default.
• W2795678220 hasConceptScore W2795678220C71924100 @default.
• W2795678220 hasFunder F4320326787 @default.
• W2795678220 hasLocation W27956782201 @default.
• W2795678220 hasLocation W27956782202 @default.
• W2795678220 hasLocation W27956782203 @default.
• W2795678220 hasLocation W27956782204 @default.
• W2795678220 hasLocation W27956782205 @default.
• W2795678220 hasOpenAccess W2795678220 @default.
• W2795678220 hasPrimaryLocation W27956782201 @default.
• W2795678220 hasRelatedWork W1995350144 @default.
• W2795678220 hasRelatedWork W2013497658 @default.
• W2795678220 hasRelatedWork W2227393071 @default.
• W2795678220 hasRelatedWork W2601691194 @default.
• W2795678220 hasRelatedWork W3121111470 @default.
• W2795678220 hasRelatedWork W3133980636 @default.
• W2795678220 hasRelatedWork W4280602684 @default.
• W2795678220 hasRelatedWork W4310092953 @default.
• W2795678220 hasRelatedWork W589679218 @default.
• W2795678220 hasRelatedWork W620566831 @default.
• W2795678220 hasVolume "2018" @default.
• W2795678220 isParatext "false" @default.
• W2795678220 isRetracted "false" @default.

• next