FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795684014> ?p ?o ?g. }

• W2795684014 abstract "ABSTRACT Adult plant resistance (APR) is an enigmatic phenomenon in which resistance genes are ineffective in protecting seedlings from disease but confer robust resistance at maturity. Maize has multiple cases in which genes confer APR to northern leaf spot, a lethal disease caused by Cochliobolus carbonum race 1 (CCR1). The first identified case of APR in maize is encoded by a hypomorphic allele, Hm1 A , at the hm1 locus. In contrast, wild type alleles of hm1 provide complete protection at all developmental stages and in every part of the maize plant. Hm1 encodes an NADPH-dependent reductase, which inactivates HC-toxin, a key virulence effector of CCR1. Cloning and characterization of Hm1 A ruled out differential transcription or translation for its APR phenotype and identified an amino acid substitution that reduced HC-toxin reductase (HCTR) activity. The possibility of a causal relationship between the weak nature of Hm1 A and its APR phenotype was confirmed by the generation of two new APR alleles of Hm1 by mutagenesis. The HCTRs encoded by these new APR alleles had undergone relatively conservative missense changes that partially reduced their enzymatic activity similar to HM1 A . No difference in accumulation of HCTR was observed between adult and juvenile plants, suggesting that the susceptibility of seedlings derives from a greater need for HCTR activity, not reduced accumulation of the gene product. Conditions and treatments that altered the photosynthetic output of the host had a dramatic effect on resistance imparted by the APR alleles, demonstrating a link between the energetic or metabolic status of the host and disease resistance affected by HC-toxin catabolism by the APR alleles of HCTR. AUTHOR SUMMARY Adult plant resistance (APR) is a phenomenon in which disease resistance genes are able to confer resistance at the adult stages of the plant but somehow fail to do so at the seedling stages. Despite the widespread occurrence of APR in various plant diseases, the mechanism underlying this trait remains obscure. It is not due to the differential transcription of these genes, and here we show that it is also not due to the differential translation or activity of the APR alleles of the maize hm1 gene at different stages of development. Using a combination of molecular genetics, biochemistry and physiology, we present multiple lines of evidence that demonstrate that APR is a feature or symptom of weak forms of resistance. While the mature parts of the plant are metabolically robust enough to manifest resistance, seedling tissues are not, leaving them vulnerable to disease. Growth conditions that compromise the photosynthetic output of the plant further deteriorate the ability of the seedlings to protect themselves from pathogens. One sentence summary Characterization of adult plant resistance in the maize-CCR1 pathosystem reveals a causal link between weak resistance and APR." @default.
• W2795684014 created "2018-04-13" @default.
• W2795684014 creator A5030771368 @default.
• W2795684014 creator A5035833387 @default.
• W2795684014 creator A5042870873 @default.
• W2795684014 creator A5059120866 @default.
• W2795684014 creator A5063134606 @default.
• W2795684014 creator A5066406045 @default.
• W2795684014 creator A5069291287 @default.
• W2795684014 creator A5070342025 @default.
• W2795684014 creator A5078397168 @default.
• W2795684014 creator A5082837697 @default.
• W2795684014 date "2018-04-04" @default.
• W2795684014 modified "2023-09-23" @default.
• W2795684014 title "Adult Plant Resistance in Maize to Northern Leaf Spot Is a Feature of Partial Loss-of-function Alleles of<i>Hm1</i>" @default.
• W2795684014 cites W1509339083 @default.
• W2795684014 cites W1522909479 @default.
• W2795684014 cites W1898512144 @default.
• W2795684014 cites W1930097109 @default.
• W2795684014 cites W1981134242 @default.
• W2795684014 cites W1985270286 @default.
• W2795684014 cites W1988819660 @default.
• W2795684014 cites W2003189219 @default.
• W2795684014 cites W2013640555 @default.
• W2795684014 cites W2015330531 @default.
• W2795684014 cites W2020325228 @default.
• W2795684014 cites W2023630642 @default.
• W2795684014 cites W2028254759 @default.
• W2795684014 cites W2046331410 @default.
• W2795684014 cites W2046805949 @default.
• W2795684014 cites W2050694525 @default.
• W2795684014 cites W2054619721 @default.
• W2795684014 cites W2055403237 @default.
• W2795684014 cites W2062027196 @default.
• W2795684014 cites W2069777315 @default.
• W2795684014 cites W2071936353 @default.
• W2795684014 cites W2075130941 @default.
• W2795684014 cites W2081422634 @default.
• W2795684014 cites W2082796840 @default.
• W2795684014 cites W2089554440 @default.
• W2795684014 cites W2094645656 @default.
• W2795684014 cites W2102376245 @default.
• W2795684014 cites W2130029642 @default.
• W2795684014 cites W2130685054 @default.
• W2795684014 cites W2142309556 @default.
• W2795684014 cites W2156946396 @default.
• W2795684014 cites W2159729657 @default.
• W2795684014 cites W2160470744 @default.
• W2795684014 cites W2162515800 @default.
• W2795684014 cites W2168904946 @default.
• W2795684014 cites W2169878227 @default.
• W2795684014 cites W2171451182 @default.
• W2795684014 cites W2184462349 @default.
• W2795684014 cites W2279380305 @default.
• W2795684014 cites W2403101829 @default.
• W2795684014 cites W2524984188 @default.
• W2795684014 cites W2558438718 @default.
• W2795684014 cites W2601877937 @default.
• W2795684014 cites W2792116459 @default.
• W2795684014 cites W4210774492 @default.
• W2795684014 cites W81394565 @default.
• W2795684014 doi "https://doi.org/10.1101/244491" @default.
• W2795684014 hasPublicationYear "2018" @default.
• W2795684014 type Work @default.
• W2795684014 sameAs 2795684014 @default.
• W2795684014 citedByCount "1" @default.
• W2795684014 countsByYear W27956840142022 @default.
• W2795684014 crossrefType "posted-content" @default.
• W2795684014 hasAuthorship W2795684014A5030771368 @default.
• W2795684014 hasAuthorship W2795684014A5035833387 @default.
• W2795684014 hasAuthorship W2795684014A5042870873 @default.
• W2795684014 hasAuthorship W2795684014A5059120866 @default.
• W2795684014 hasAuthorship W2795684014A5063134606 @default.
• W2795684014 hasAuthorship W2795684014A5066406045 @default.
• W2795684014 hasAuthorship W2795684014A5069291287 @default.
• W2795684014 hasAuthorship W2795684014A5070342025 @default.
• W2795684014 hasAuthorship W2795684014A5078397168 @default.
• W2795684014 hasAuthorship W2795684014A5082837697 @default.
• W2795684014 hasBestOaLocation W27956840141 @default.
• W2795684014 hasConcept C104317684 @default.
• W2795684014 hasConcept C127716648 @default.
• W2795684014 hasConcept C143065580 @default.
• W2795684014 hasConcept C180754005 @default.
• W2795684014 hasConcept C207583985 @default.
• W2795684014 hasConcept C54355233 @default.
• W2795684014 hasConcept C84597430 @default.
• W2795684014 hasConcept C86803240 @default.
• W2795684014 hasConceptScore W2795684014C104317684 @default.
• W2795684014 hasConceptScore W2795684014C127716648 @default.
• W2795684014 hasConceptScore W2795684014C143065580 @default.
• W2795684014 hasConceptScore W2795684014C180754005 @default.
• W2795684014 hasConceptScore W2795684014C207583985 @default.
• W2795684014 hasConceptScore W2795684014C54355233 @default.
• W2795684014 hasConceptScore W2795684014C84597430 @default.
• W2795684014 hasConceptScore W2795684014C86803240 @default.
• W2795684014 hasLocation W27956840141 @default.
• W2795684014 hasLocation W27956840142 @default.
• W2795684014 hasOpenAccess W2795684014 @default.
• W2795684014 hasPrimaryLocation W27956840141 @default.
• W2795684014 hasRelatedWork W1763202394 @default.

• next