FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795691607> ?p ?o ?g. }

• W2795691607 endingPage "3067" @default.
• W2795691607 startingPage "3058" @default.
• W2795691607 abstract "Surface modification is of significant interest in biomaterials, biosensors, and device biocompatibility. Immobilization of bioactive or biomimetic molecules is a common method of disguising a foreign body as host tissue to decrease the foreign body response (FBR) and/or increase device-tissue integration. For example, in neural interfacing devices, immobilization of L1, a neuron-specific adhesion molecule, has been shown to increase neuron adhesion and reduce inflammatory gliosis on and around the implants. However, the activity of modified surfaces is limited by the relatively low concentration of the immobilized component, in part due to the low surface area of flat surfaces available for modification. In this work, we demonstrate a novel method for increasing the device surface area by attaching a layer of thiolated silica nanoparticles (TNPs). This coating method results in an almost two-fold increase in the immobilized L1 protein. L1 immobilized nanotextured surfaces showed a 100% increase in neurite outgrowth than smooth L1 immobilized surfaces without increasing the adhesion of astrocytes in vitro. The increased bioactivity observed in the cell assay was determined to be mainly due to the higher protein surface density, not the increase in surface roughness. In addition, we tested immobilization of a superoxide dismutase mimic (SODm) on smooth and roughened substrates. The SODm immobilized rough surfaces demonstrated an increase of 145% in superoxide scavenging activity compared to chemically matched smooth surfaces. These results not only show promise in improving biomimetic coating for neural implants, but may also improve surface immobilization efficacy in other fields such as catalysts, protein purification, sensors, and tissue engineering devices." @default.
• W2795691607 created "2018-04-13" @default.
• W2795691607 creator A5016181204 @default.
• W2795691607 creator A5084264585 @default.
• W2795691607 creator A5089332805 @default.
• W2795691607 date "2018-01-01" @default.
• W2795691607 modified "2023-10-14" @default.
• W2795691607 title "Enhancing surface immobilization of bioactive molecules<i>via</i>a silica nanoparticle based coating" @default.
• W2795691607 cites W1507170913 @default.
• W2795691607 cites W1566383707 @default.
• W2795691607 cites W1628719417 @default.
• W2795691607 cites W1966132736 @default.
• W2795691607 cites W1983139188 @default.
• W2795691607 cites W1988067509 @default.
• W2795691607 cites W2001702704 @default.
• W2795691607 cites W2003802768 @default.
• W2795691607 cites W2004602103 @default.
• W2795691607 cites W2012131098 @default.
• W2795691607 cites W2022850908 @default.
• W2795691607 cites W2026370963 @default.
• W2795691607 cites W2034509808 @default.
• W2795691607 cites W2039277433 @default.
• W2795691607 cites W2059468888 @default.
• W2795691607 cites W2070268956 @default.
• W2795691607 cites W2073726089 @default.
• W2795691607 cites W2074299379 @default.
• W2795691607 cites W2077955921 @default.
• W2795691607 cites W2081225544 @default.
• W2795691607 cites W2107635023 @default.
• W2795691607 cites W2115616340 @default.
• W2795691607 cites W2122922916 @default.
• W2795691607 cites W2130233910 @default.
• W2795691607 cites W2135907032 @default.
• W2795691607 cites W2141957506 @default.
• W2795691607 cites W2144625879 @default.
• W2795691607 cites W2151549305 @default.
• W2795691607 cites W2152752812 @default.
• W2795691607 cites W2164060969 @default.
• W2795691607 cites W2170400855 @default.
• W2795691607 cites W2266041004 @default.
• W2795691607 cites W2546721731 @default.
• W2795691607 cites W2592252315 @default.
• W2795691607 cites W2745848444 @default.
• W2795691607 cites W2750170772 @default.
• W2795691607 cites W379237053 @default.
• W2795691607 cites W4211136402 @default.
• W2795691607 cites W4251460371 @default.
• W2795691607 doi "https://doi.org/10.1039/c8tb00408k" @default.
• W2795691607 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6242288" @default.
• W2795691607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30464839" @default.
• W2795691607 hasPublicationYear "2018" @default.
• W2795691607 type Work @default.
• W2795691607 sameAs 2795691607 @default.
• W2795691607 citedByCount "17" @default.
• W2795691607 countsByYear W27956916072018 @default.
• W2795691607 countsByYear W27956916072019 @default.
• W2795691607 countsByYear W27956916072020 @default.
• W2795691607 countsByYear W27956916072021 @default.
• W2795691607 countsByYear W27956916072022 @default.
• W2795691607 countsByYear W27956916072023 @default.
• W2795691607 crossrefType "journal-article" @default.
• W2795691607 hasAuthorship W2795691607A5016181204 @default.
• W2795691607 hasAuthorship W2795691607A5084264585 @default.
• W2795691607 hasAuthorship W2795691607A5089332805 @default.
• W2795691607 hasBestOaLocation W27956916072 @default.
• W2795691607 hasConcept C107365816 @default.
• W2795691607 hasConcept C115537861 @default.
• W2795691607 hasConcept C12554922 @default.
• W2795691607 hasConcept C127413603 @default.
• W2795691607 hasConcept C155672457 @default.
• W2795691607 hasConcept C159985019 @default.
• W2795691607 hasConcept C160756335 @default.
• W2795691607 hasConcept C171250308 @default.
• W2795691607 hasConcept C191897082 @default.
• W2795691607 hasConcept C192562407 @default.
• W2795691607 hasConcept C2777230088 @default.
• W2795691607 hasConcept C2781448156 @default.
• W2795691607 hasConcept C42360764 @default.
• W2795691607 hasConcept C84416704 @default.
• W2795691607 hasConcept C85789140 @default.
• W2795691607 hasConcept C86803240 @default.
• W2795691607 hasConceptScore W2795691607C107365816 @default.
• W2795691607 hasConceptScore W2795691607C115537861 @default.
• W2795691607 hasConceptScore W2795691607C12554922 @default.
• W2795691607 hasConceptScore W2795691607C127413603 @default.
• W2795691607 hasConceptScore W2795691607C155672457 @default.
• W2795691607 hasConceptScore W2795691607C159985019 @default.
• W2795691607 hasConceptScore W2795691607C160756335 @default.
• W2795691607 hasConceptScore W2795691607C171250308 @default.
• W2795691607 hasConceptScore W2795691607C191897082 @default.
• W2795691607 hasConceptScore W2795691607C192562407 @default.
• W2795691607 hasConceptScore W2795691607C2777230088 @default.
• W2795691607 hasConceptScore W2795691607C2781448156 @default.
• W2795691607 hasConceptScore W2795691607C42360764 @default.
• W2795691607 hasConceptScore W2795691607C84416704 @default.
• W2795691607 hasConceptScore W2795691607C85789140 @default.
• W2795691607 hasConceptScore W2795691607C86803240 @default.
• W2795691607 hasFunder F4320337359 @default.

• next