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• W2795698891 abstract "Studies suggest that patients with deep vein thrombosis and diabetes often have hypercoagulable blood plasma, leading to a higher risk of thromboembolism formation through the rupture of blood clots, which may lead to stroke and death. Despite many advances in the field of blood clot formation and thrombosis, the influence of mechanical properties of fibrin in the formation of thromboembolisms in platelet-poor plasma is poorly understood. In this paper, we combine the concepts of reactive molecular dynamics and coarse-grained molecular modeling to predict the complex network formation of fibrin clots and the branching of fibrin monomers. The 340-kDa fibrinogen molecule was converted into a coarse-grained molecule with nine beads, and using our customized reactive potentials, we simulated the formation and polymerization process of a fibrin clot. The results show that higher concentrations of thrombin result in higher branch-point formation in the fibrin clot structure. Our results also highlight many interesting properties, such as the formation of thicker or thinner fibers depending on the thrombin concentration. To the best of our knowledge, this is the first successful molecular polymerization study of fibrin clots to focus on thrombin concentration." @default.
• W2795698891 created "2018-04-13" @default.
• W2795698891 creator A5021658880 @default.
• W2795698891 creator A5073262733 @default.
• W2795698891 creator A5075797472 @default.
• W2795698891 date "2018-04-05" @default.
• W2795698891 modified "2023-10-02" @default.
• W2795698891 title "Coarse-grained molecular dynamics simulations of fibrin polymerization: effects of thrombin concentration on fibrin clot structure" @default.
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• W2795698891 doi "https://doi.org/10.1007/s00894-018-3642-7" @default.
• W2795698891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29623504" @default.
• W2795698891 hasPublicationYear "2018" @default.
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