FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795704013> ?p ?o ?g. }

• W2795704013 endingPage "1092" @default.
• W2795704013 startingPage "1092" @default.
• W2795704013 abstract "Patients with dementia present epilepsy more frequently than the general population. Seizures are more common in patients with Alzheimer’s disease (AD), dementia with Lewy bodies (LBD), frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP) than in other dementias. Missense mutations in the microtubule associated protein tau (MAPT) gene have been found to cause familial FTD and PSP, while the P301S mutation in MAPT has been associated with early-onset fast progressive dementia and the presence of seizures. Brains of patients with AD, LBD, FTD and PSP show hyperphosphorylated tau aggregates, amyloid-β plaques and neuropil threads. Increasing evidence suggests the existence of overlapping mechanisms related to the generation of network hyperexcitability and cognitive decline. Neuronal overexpression of tau with various mutations found in FTD with parkinsonism-linked to chromosome 17 (FTDP-17) in mice produces epileptic activity. On the other hand, the use of certain antiepileptic drugs in animal models with AD prevents cognitive impairment. Further efforts should be made to search for plausible common targets for both conditions. Moreover, attempts should also be made to evaluate the use of drugs targeting tau and amyloid-β as suitable pharmacological interventions in epileptic disorders. The diagnosis of dementia and epilepsy in early stages of those diseases may be helpful for the initiation of treatments that could prevent the generation of epileptic activity and cognitive deterioration." @default.
• W2795704013 created "2018-04-13" @default.
• W2795704013 creator A5000019477 @default.
• W2795704013 creator A5030492301 @default.
• W2795704013 creator A5080274904 @default.
• W2795704013 creator A5083768205 @default.
• W2795704013 creator A5089447741 @default.
• W2795704013 date "2018-04-05" @default.
• W2795704013 modified "2023-10-16" @default.
• W2795704013 title "Tau-Induced Pathology in Epilepsy and Dementia: Notions from Patients and Animal Models" @default.
• W2795704013 cites W114737604 @default.
• W2795704013 cites W1260792146 @default.
• W2795704013 cites W134764564 @default.
• W2795704013 cites W1480524175 @default.
• W2795704013 cites W1481130297 @default.
• W2795704013 cites W1511517753 @default.
• W2795704013 cites W1513788662 @default.
• W2795704013 cites W1546797865 @default.
• W2795704013 cites W1570043013 @default.
• W2795704013 cites W1580520973 @default.
• W2795704013 cites W1586802262 @default.
• W2795704013 cites W1597859722 @default.
• W2795704013 cites W1611407165 @default.
• W2795704013 cites W1656191917 @default.
• W2795704013 cites W1900267874 @default.
• W2795704013 cites W1921353230 @default.
• W2795704013 cites W1957167348 @default.
• W2795704013 cites W1964597210 @default.
• W2795704013 cites W1965284943 @default.
• W2795704013 cites W1966074371 @default.
• W2795704013 cites W1966193366 @default.
• W2795704013 cites W1967347174 @default.
• W2795704013 cites W1968317065 @default.
• W2795704013 cites W1968937229 @default.
• W2795704013 cites W1970910654 @default.
• W2795704013 cites W1972886222 @default.
• W2795704013 cites W1975040221 @default.
• W2795704013 cites W1976023110 @default.
• W2795704013 cites W1977683347 @default.
• W2795704013 cites W1979612107 @default.
• W2795704013 cites W1981141308 @default.
• W2795704013 cites W1981458288 @default.
• W2795704013 cites W1981856617 @default.
• W2795704013 cites W1984776020 @default.
• W2795704013 cites W1985060509 @default.
• W2795704013 cites W1985131940 @default.
• W2795704013 cites W1986442971 @default.
• W2795704013 cites W1988036480 @default.
• W2795704013 cites W1988571716 @default.
• W2795704013 cites W1988979381 @default.
• W2795704013 cites W1991625887 @default.
• W2795704013 cites W1996310912 @default.
• W2795704013 cites W1996314668 @default.
• W2795704013 cites W1996444571 @default.
• W2795704013 cites W1996917933 @default.
• W2795704013 cites W1997124058 @default.
• W2795704013 cites W1997604119 @default.
• W2795704013 cites W1997709907 @default.
• W2795704013 cites W1999792780 @default.
• W2795704013 cites W2001664582 @default.
• W2795704013 cites W2002164075 @default.
• W2795704013 cites W2004713321 @default.
• W2795704013 cites W2004852048 @default.
• W2795704013 cites W2005553101 @default.
• W2795704013 cites W2005855536 @default.
• W2795704013 cites W2006472192 @default.
• W2795704013 cites W2007898025 @default.
• W2795704013 cites W2009910508 @default.
• W2795704013 cites W2010891279 @default.
• W2795704013 cites W2011385800 @default.
• W2795704013 cites W2014483271 @default.
• W2795704013 cites W2015052735 @default.
• W2795704013 cites W2016406742 @default.
• W2795704013 cites W2016479797 @default.
• W2795704013 cites W2016777985 @default.
• W2795704013 cites W2018144108 @default.
• W2795704013 cites W2019254928 @default.
• W2795704013 cites W2020282265 @default.
• W2795704013 cites W2022094507 @default.
• W2795704013 cites W2022245282 @default.
• W2795704013 cites W2022532556 @default.
• W2795704013 cites W2023986336 @default.
• W2795704013 cites W2024266852 @default.
• W2795704013 cites W2024941524 @default.
• W2795704013 cites W2030317956 @default.
• W2795704013 cites W2031179697 @default.
• W2795704013 cites W2031574080 @default.
• W2795704013 cites W2034551067 @default.
• W2795704013 cites W2034969383 @default.
• W2795704013 cites W2036362108 @default.
• W2795704013 cites W2036755018 @default.
• W2795704013 cites W2037059312 @default.
• W2795704013 cites W2040661002 @default.
• W2795704013 cites W2041142924 @default.
• W2795704013 cites W2043798779 @default.
• W2795704013 cites W2046672806 @default.
• W2795704013 cites W2046847750 @default.
• W2795704013 cites W2047948527 @default.

• next