FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795854920> ?p ?o ?g. }

• W2795854920 abstract "Abstract Saccharomyces cerevisiae Mus81 is a structure-selective endonuclease which constitutes an alternative pathway in parallel with the helicase-topoisomerase Sgs1-Top3-Rmi1 complex to resolve a number of DNA intermediates during DNA replication, repair, and homologous recombination. Previously, it was showed that the N-terminal region of Mus81 was required for its in vivo function in a redundant manner with Sgs1; mus81Δ120N mutant that lacks the first 120 amino acid residues at the N-terminus exhibited synthetic lethality in combination with the loss of SGS1. In this study, the physiologically important role of the N-terminal region of Mus81 in processing toxic intermediates was further investigated. We examined the cellular defect of sgs1Δmus81Δ100N cells and observed that although viable, the cells became very sensitive to DNA damaging agents. A single-copy suppressor screening to seek for a factor(s) that could rescue the drug sensitivity of sgs1Δmus81Δ100N cells was performed and revealed that Flp1, a site-specific recombinase 1 encoded on the 2-micron plasmid was a suppressor. Moreover, Flp1 overexpression could partially suppress the drug sensitivity of mus81Δ cells at 37 °C. Our findings suggest a possible function of Flp1 in coordination with Mus81 and Sgs1 to jointly resolve the branched-DNA structures generated in cells attempting to repair DNA damages." @default.
• W2795854920 created "2018-04-13" @default.
• W2795854920 creator A5015323928 @default.
• W2795854920 creator A5021670064 @default.
• W2795854920 creator A5044887459 @default.
• W2795854920 date "2018-08-01" @default.
• W2795854920 modified "2023-09-25" @default.
• W2795854920 title "The possible function of Flp1 in homologous recombination repair in Saccharomyces cerevisiae" @default.
• W2795854920 cites W136476865 @default.
• W2795854920 cites W1864140687 @default.
• W2795854920 cites W1964714687 @default.
• W2795854920 cites W1968676497 @default.
• W2795854920 cites W1973822043 @default.
• W2795854920 cites W1980838719 @default.
• W2795854920 cites W1989779163 @default.
• W2795854920 cites W1994542613 @default.
• W2795854920 cites W2003885077 @default.
• W2795854920 cites W2013292795 @default.
• W2795854920 cites W2028774533 @default.
• W2795854920 cites W2041945142 @default.
• W2795854920 cites W2052513354 @default.
• W2795854920 cites W2057628430 @default.
• W2795854920 cites W2061311583 @default.
• W2795854920 cites W2061545358 @default.
• W2795854920 cites W2065761939 @default.
• W2795854920 cites W2072707948 @default.
• W2795854920 cites W2078885650 @default.
• W2795854920 cites W2087033941 @default.
• W2795854920 cites W2102254262 @default.
• W2795854920 cites W2103972950 @default.
• W2795854920 cites W2108572433 @default.
• W2795854920 cites W2111583572 @default.
• W2795854920 cites W2112746887 @default.
• W2795854920 cites W2126046383 @default.
• W2795854920 cites W2127917404 @default.
• W2795854920 cites W2128202064 @default.
• W2795854920 cites W2130685717 @default.
• W2795854920 cites W2143444058 @default.
• W2795854920 cites W2160781488 @default.
• W2795854920 cites W2166898800 @default.
• W2795854920 cites W2169302228 @default.
• W2795854920 cites W2278698827 @default.
• W2795854920 cites W2505491515 @default.
• W2795854920 cites W2527311265 @default.
• W2795854920 cites W2572506455 @default.
• W2795854920 cites W2746570035 @default.
• W2795854920 cites W2763065016 @default.
• W2795854920 cites W2171082614 @default.
• W2795854920 doi "https://doi.org/10.3934/genet.2018.2.161" @default.
• W2795854920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6698574" @default.
• W2795854920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31435519" @default.
• W2795854920 hasPublicationYear "2018" @default.
• W2795854920 type Work @default.
• W2795854920 sameAs 2795854920 @default.
• W2795854920 citedByCount "0" @default.
• W2795854920 crossrefType "journal-article" @default.
• W2795854920 hasAuthorship W2795854920A5015323928 @default.
• W2795854920 hasAuthorship W2795854920A5021670064 @default.
• W2795854920 hasAuthorship W2795854920A5044887459 @default.
• W2795854920 hasBestOaLocation W27958549201 @default.
• W2795854920 hasConcept C101434241 @default.
• W2795854920 hasConcept C102744134 @default.
• W2795854920 hasConcept C104317684 @default.
• W2795854920 hasConcept C130965112 @default.
• W2795854920 hasConcept C134935766 @default.
• W2795854920 hasConcept C135300049 @default.
• W2795854920 hasConcept C143425029 @default.
• W2795854920 hasConcept C147897179 @default.
• W2795854920 hasConcept C156695909 @default.
• W2795854920 hasConcept C161223559 @default.
• W2795854920 hasConcept C22744801 @default.
• W2795854920 hasConcept C2777576037 @default.
• W2795854920 hasConcept C2778502085 @default.
• W2795854920 hasConcept C54355233 @default.
• W2795854920 hasConcept C552990157 @default.
• W2795854920 hasConcept C67705224 @default.
• W2795854920 hasConcept C73573662 @default.
• W2795854920 hasConcept C86803240 @default.
• W2795854920 hasConcept C95444343 @default.
• W2795854920 hasConceptScore W2795854920C101434241 @default.
• W2795854920 hasConceptScore W2795854920C102744134 @default.
• W2795854920 hasConceptScore W2795854920C104317684 @default.
• W2795854920 hasConceptScore W2795854920C130965112 @default.
• W2795854920 hasConceptScore W2795854920C134935766 @default.
• W2795854920 hasConceptScore W2795854920C135300049 @default.
• W2795854920 hasConceptScore W2795854920C143425029 @default.
• W2795854920 hasConceptScore W2795854920C147897179 @default.
• W2795854920 hasConceptScore W2795854920C156695909 @default.
• W2795854920 hasConceptScore W2795854920C161223559 @default.
• W2795854920 hasConceptScore W2795854920C22744801 @default.
• W2795854920 hasConceptScore W2795854920C2777576037 @default.
• W2795854920 hasConceptScore W2795854920C2778502085 @default.
• W2795854920 hasConceptScore W2795854920C54355233 @default.
• W2795854920 hasConceptScore W2795854920C552990157 @default.
• W2795854920 hasConceptScore W2795854920C67705224 @default.
• W2795854920 hasConceptScore W2795854920C73573662 @default.
• W2795854920 hasConceptScore W2795854920C86803240 @default.
• W2795854920 hasConceptScore W2795854920C95444343 @default.
• W2795854920 hasLocation W27958549201 @default.
• W2795854920 hasLocation W27958549202 @default.

• next